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2001 Fiscal Year Final Research Report Summary

Experimental Myocardial Preservation Study of adding Perfluorochemicals (FC43) in Lidocaine Cardioplegia

Research Project

Project/Area Number 11671340
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionShowa University

Principal Investigator

INOUE Koichi  Showa University, School of Medicine, assistant professor, 医学部, 助教授 (10151606)

Co-Investigator(Kenkyū-buntansha) TAKABA Toshihiro  Showa University, School of medicine, professor, 医学部, 教授 (00053851)
YAMADA Makoto  Showa University, School of medicine, lecturer, 医学部, 講師 (20230477)
Project Period (FY) 1999 – 2000
KeywordsPerfluorochemicals / Lidocaine / intracellular Ca / reperfusion injury / myocardial protection
Research Abstract

Objective :
Lidocaine exhibits a cardioplegic action via acute inhibition of sodium influx into the myocardial cells. In terms of the cardiac function and calcium dynamics in the myocardial cells, we investigated the myocardial protective effect of addition of FC43 of perfluorochemicals, which has an excellent oxygen transport function to meet the myocardial oxygen demand, on lidocaine induced cardioplegia.
Methods :
Isolated rat hearts were perfused with Langendorff mode and were divided to three experimental groups. During of preservation, these hearts were perfused continuously with the next three solution, potassium chloride was added to Krebs-Henseleit bicarbonate buffer to make potassium concentration of 20 mM in the first group (Group A), 2 mM lidocaine was added to Krebs-Henseleit bicarbonate buffer in the second group (Group B), and 2 mM lidocaine and 20% FC43 were added to Krebs-Henseleit bicarbonate buffer in the third group (Group C). After 60 minutes of continuous perfusion, the cardiac function and the intracellular calcium concentration in Groups A and B during cardioplegia were measured, Furthermore, after 360 minutes of continuous coronary perfusion, the cardiac function were measured in Group B and Group C.
Results and Conclusions :
Lidocaine cardioplegia showed a good recovery of cardiac function, because lidocaine induced prompt cardiac arrest by blocking sodium influx and inhibited the intracellular calcium overload by the following inhibition of sodium calcium channels. Moreover, our results suggested that combining perfluorochemicals with lidocaine produced a more effective myocardial preservation that meets the myocardial oxygen demand during long term cardiac arrest.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 安藤 進, 井上恒一, 尾頭 厚, 高場利博: "Lidocaine cardioplegiaの検討、St. Thomas'cardioplegiaとの比較"心筋の構造と代謝. 21. 233-238 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 尾頭 厚, 井上恒一, 浅野 満, 安藤 進, 高場利博: "Experimental Myocardial Preservation Study of adding Perfluorochemicals(FC43) in Lidocaine Cardioplegia"The Japanese journal of THORACIC AND CARDIOVASCULAR SURGERY. 48. 280-290 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 尾頭 厚, 井上恒一, 浅野 満, 安藤 進, 高場利博: "Lidocaine cardioplegiaの心筋保護効果に関する実験的検討、-心機能および細胞内Ca動態の面から-"心筋の構造と代謝. 22. 65-70 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Susumu Ando, Koichi Inoue, Atsushi Bito, Tbshihiro Takaba: "A study of Lidocaine cardioplegia Comparison with St. Thomas' cardioplegia"Cardiac Structure and Metabolism. 21. 233-238 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Atsushi Bito, Koichi Inoue, Mitsuru Asano, Susumu Ando Toshihiro Takaba: "Experimental Mybcardial Preservation Study of adding Perfluorochemicals (FC43) in Lidocaine Cardioplegia"The Japanese journal of THORACIC AND CARDIOVASCULAR SURGERY. 48, No.5. 280-290 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Atsushi Bito, Koichi Inoue, Mitsuru Asano, Susumu Ando Toshihiro Takaba: "Experimental myocardial preservative study of lidocaine cardioplegia"Cardiac Structure and Metabolism. 22. 65-70 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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