2001 Fiscal Year Final Research Report Summary
Antitumor activity by intracellular hyperthermia using magnetite
| Project/Area Number |
11671365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya University |
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Principal Investigator |
WAKABAYASHI Toshihiko School of Medicine., Nagoya University Associate Professor, 医学部, 助教授 (50220835)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Jun Graduate School of Medicine, Nagoya University Professor, 大学院・医学研究科, 教授 (40158449)
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| Project Period (FY) |
1999 – 2001
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| Keywords | Hyperthermia / Magnetite / Brain tumor / Liposome / Immunoreaction / Hysteresis loss |
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| Research Abstract |
Intratumoral effect of Carboxymethylcellulose(CMC)-magnetite, which newly produced, under hyperthermic condition was demonstrated in this study. CMC and magnetite particles were mingled and a stick type magnetite was developed to obtain higher hyperthermic effect. This type magnetite was injected stereotactically into the T9 glioma in the rat brain and these rats were applied to the high frequent magnetic field. Stick type CMC-magnetite spread among the tumor tissue after application into the magnetic field. This static magnetic field application also stimulates the magnetite particles and could produce heat enough to induce tumor necrosis. This study of hyperthermia also demonstrated assembling macrophages and lymphocytes just around the magnetite, which indicates possibility of heated magnetite to induce activation of immunoreaction in the brain
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