The experimental study of the tendor repair

2001 Fiscal Year Final Research Report Summary

• Project/Area Number: 11671436
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: HIROSHIMA UNIVERSITY
• Principal Investigator: MOCHIZUKI Yu Hiroshima University, Assistant, 医学部, 助手 (10284192)
• Co-Investigator(Kenkyū-buntansha): DEIE Masataka Hiroshima University, University Medical Hospital, Fellow, 医学部・附属病院, 医員 ; SUGITA Takashi Hiroshima University, Assistant Professor, 医学部, 助教授 (40235883)
• Project Period (FY): 1999 – 2001
• Keywords: tendon / regeneration / growth factor

Research Abstract

Recently, the study for the tissue regeneration has become one of the topics of the research of the medical field. The tendon tissues are strong and consists of rich collagen fibers. However, the healing process of the tendon is unknown. In this study, we have focused on the growth factor for the accelerating the repair process. At first, we would like to identify the character and time of the expression of the reparative cells and growth factors in the healing process of the tendon using immunohistological staining and in situ hybridization procedure.
We analyzed the time of expression of TGF-β and FGF, Type collagen , Type collagen.
The results are as follows ; The TGF-β has showed the maximum expression at the period of 1 and 2 weeks after surgery. Continuously the expression of FGF has become the peak. At the same time, the expression of the Type collagen has become the peak. Continuously the expression of Type collagen has become the peak.
Consequently we should establish the optimum concentration and area, method of each growth factor.