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2001 Fiscal Year Final Research Report Summary

THE EFFECTS OF INHIBITORS OF OSTEOCLASTC BONE RESORPTION IN GIANT CELL TUMOR

Research Project

Project/Area Number 11671443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionOITA MEDICAL UNIVERSITY

Principal Investigator

YOSHIDA Seiji  OITA MEDICAL UNIVERSITY, ORTHOPAEDICS, ASSISTANT, 医学部, 助手 (70182764)

Co-Investigator(Kenkyū-buntansha) KATAOKA Masashi  OITA MEDICAL UNIVERSITY, ORTHOPAEDICS, ASSISTANT, 医学部, 助手 (40301379)
Project Period (FY) 1999 – 2000
KeywordsGiant cell tumor / Bisphosphonate / Estrogen / TRAP / TRAP
Research Abstract

Bisphosphonates inhibit bone resorption and are therapeutically effective in diseases of increased bone turnover, such as Paget's disease and hypercalcemia of malignancy. The mechanisms by which they act remain unclear. Proposed mechanisms include inhibition of osteoclast formation from precursors and inhibitory or toxic effect on mature osteoclasts. We have developed a new in vitro model to study osteoclast survival and in this paper that may explain both the observed reduction in osteoclast numbers and in bone resorption by mature osteoclasts, namely that bisphosphonates induce programd cell death (apoptosis). Three bisphosphonates caused a 4- to 24-fold increase in the proportion of osteoclasts showing the characteristic morphology of apoptosis in vitro. Of the three compounds, risedronate, the most potent inhibitor of bone resorption in vivo, was the strongest inducer of osteoclast apoptosis in vitro. Osteoclast apoptosis may therefore be a major mechanism whereby bisphosphonates reduce osteoclast numbers and activity, and induction of apoptosis could be a therapeutic goal for new antiosteoclast drugs.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] M.Ktaoka, et al.: "Pole of multinuclear cells in granulation tissue in osteomyelitis"Acta Orthop Scand. 71(4). 414-418 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Yoshida, et al.: "Idiopathic heterotopic Ossification within the tibial nerve"J.B.J.S, American volume. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Kataoka, et al.: "An Assessment of Histpathological Critenia for Infection in Joint Arthroplasty in Pheumatoid Synoviam"Clinical Pheumatology. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. KATAOKA, et al.: "ROLE OF MULTINUCLEAR CELLS IN GRANURATION TISSUE IN OSTEOMYELITIS"Acta Orthop Scand. Vol.71, No.4. 414-418 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. YOSHIDA, et al.: "IDIOPATHIC HETEROTOPIC OSSIFICATION WITHIN THE TIBIAL NERVE. J.B.J.S."(in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. KATAOKA, et al.: "AN ASSESSMENT OF HISTOPATHOLOGICAL CRITERIA FOR INFECTION IN JOINT ARTHROPLASTY IN RHEUMATOID SYNOVIUM"(in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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