2001 Fiscal Year Final Research Report Summary
Biochemical and biomechanical analysis of irradiated allograte and remidelling of the transplantation
| Project/Area Number |
11671470
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Osaka Prefectural College of Nursing |
|---|
Principal Investigator |
KOUSEI Shiro Osaka University, associate proffesor, 教授 (40135679)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HAMADA Masayoki Osaka Prefecture College of Health Science, Professor, 医学部, 講師 (90303958)
|
|---|
| Project Period (FY) |
1999 – 2000
|
| Keywords | allograte / irradiation / remodeling / biomechanics / biochemical study |
|---|
| Research Abstract |
We focused on the effect of radiation of allogeneic tendons and remodeling process during the period of this Grant-in-Aid for Scientific Research.
1. Biochemical and biomechanical analysis of the irradiated allogeneic tendons after transplantation using rat animal model Rat allogeneic tendon/ligament transplatation model by substitution of the patellar tendon with allografts demonstrated that radiation promoted turn-over of the collagen fibril after transplantation and its effect was enhanced more in the freeze-dried tendons than in the freshfrozen. Biomechanical analysis proved that irradiation of the allogeneic tendons decreased their tensile strength after transplantation. There was no statistically difference between the freshfrozen group and in the freeze-dried one. The tensile strength of the grafts increased 6 weeks after transplantation in the both group.
2. Human clinical usage of irradiated allograft. Lateral ligaments of human ankle joint were reconstructed using irradiated allograft. Clinical study showed these patients have satisfactory stability of their ankle and good range of ankle motion after operation.
3. Biomechanical analysis of grafts using a robotic simulator Anterior cruciate ligament reconstruction via two-femoral socket provided better anterior-posterior stability compared with the conventional reconstruction using a single socket.
|
Research Products
(19 results)
