2000 Fiscal Year Final Research Report Summary
Mechanisms of Anesthetics-induced preconditioning in Isolated Heart
| Project/Area Number |
11671482
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokyo medical and dental university |
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Principal Investigator |
SAKAI Fmio Tokyo Medical & Dental u,n,v, Faculty of Mediein Research Associat, 医学部附属病院, 助手 (80302868)
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| Co-Investigator(Kenkyū-buntansha) |
SAWANOBORI Tohru Tokyo Medical & Dental u,n,v, Medical Reserch Institute,Professor, 難治疾患研究所, 教授 (00014217)
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| Project Period (FY) |
1999 – 2000
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| Keywords | S100 / sinus node / propofol |
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| Research Abstract |
1,The cerebral protein S100 released into Blood during cardiopulmonary bypass (CPB) was investigated. Seventeen adults undergoing cardiac operations with a median age of 57.5 years were enrolled in this study. The aerum concentrations of S100 (dimere ββ) were analyzed with a commercially available immunoluminometric assay kit. In comparison to the pre-CPB values, a significant increase in the concentration, of protein S100 was found immediately after the atart of CPB. There was a continuous elevation of the concentration of S100 in the following phases of CPB. However, the main release of S100 was found in the end of CPB.
2, The effect of propofol(l-50μM) on sinoatrial pacemaker activity was investigated in isolated atrial rabbit preparations. Propofol induced dose-dependent decreases in atrial rate and action potential duration. The propofol-induced negative chronotropic effect was not inhibited by atropine. These results indicated that propofol directly depress sinoatrial pacemaker activity and that propofob-induced negative chronotropic effect dose not involve the activation of muscarinic receptors. Given the marked rate dependence of propofol's sinus nodal actions, this anesthetic agent may impart antidysrhymic protection to those patients undergoing surgical operations.
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