2000 Fiscal Year Final Research Report Summary
The Role of c-fos gene in Neuropathic Pain
| Project/Area Number |
11671487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yamanashi Medical University |
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Principal Investigator |
KASHIMOTO Satoshi Yamanashi Medical University, Department of Anesthesiology, Associate Professor, 医学部, 助教授 (60152633)
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| Co-Investigator(Kenkyū-buntansha) |
IIJIMA Tetuya Yamanashi Medical University, Department of Anesthesiology, Instructor, 医学部, 助手 (70324209)
OGUCHI Takeshi Yamanashi Medical University, Department of Anesthesiology, Assistant Professor, 医学部, 講師 (60201399)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Neuropathic Pain / c-fos / partial nerveinjury model |
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| Research Abstract |
Malmberg (1998) demonstrated that C57BL6 mice, which received a tight ligature aroud 1/3 to 1/2 of the diameter of the sciatic nerve, can be used as a model of neuropathic pain. We tied the same ligature around the sciatic nerve of Std : ddy mice. The mice, which received the partial sciatic nerve injury, tend to show the threshold changes on thermal and mechanical stimuli.
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