2000 Fiscal Year Final Research Report Summary
EFFECTS OF ALPHA2-ADRENERGIC AGONISTS AND NMDA-ANTAGONISTS ON CEREBRAL MICROCIRCULATION UNDER THE HYPOTHERMIC CONDITION -ASSESSED WITH CLOSED CRANIAL WINDOW TECHNIQUE-.
| Project/Area Number |
11671489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | GIFU UNIVERSITY |
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Principal Investigator |
IIDA Hiroki DEPATMENT OF ANESTHESIOLOGY AND CRITICAL CARE MEDICINE, GIFU UNIVERSITY ASSOCIATE PROFESSOR, 医学部, 助教授 (30159561)
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| Co-Investigator(Kenkyū-buntansha) |
DOHI Shuji DEPATMENT OF ANESTHESIOLOGY AND CRITICAL CARE MEDICINE, GIFU UNIVERSITY PROFESSOR, 医学部, 教授 (40155627)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Alpha2-adrenergic agonist / NMDA antagonist / Cerebral vessel / Microcirculation / Hypothermia |
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| Research Abstract |
Pentobarbital anesthetized animals were prepared for measurement of cerebral pial vessel diameter in a cranial window preparation. We investigated the experiments according to following protocols.
(1) To investigate the effect of ketamine on cerebrovascular response to isoflurane and sevoflurane. ; Ketamine itself did not induce cerebrovascular dilation. The vasodilation of cerebral pial vessels induced by isoflurane and sevoflurane could be attenuated by the systemic administration of ketamine, and the response of pial vessels to PaCO2 also attenuated.
(2) To compare the effect of topical dexmedetomidine on cerebral pial vessel diameter under normothermic or hypothemic condition ; In normothermic condition the topical administration of 10^<-7> M and 10^<-5> M dexmedetomidine induced a vasodilation of cerebral pial vessels, whereas in hypothermic condition the topical administration of the same concentration of dexmedetomidine induced a vasoconstriction of cerebral pial vessels. The higher concentration (10^<-3>M) of dexmedetomidine induced a vasodilation of cerebral pial vessels in both normothermic and hypothermic condition.
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