2001 Fiscal Year Final Research Report Summary
Analysis of exhaled nitric oxide (NO) in the surgical patients by real-time exhaled NO measuring system
| Project/Area Number |
11671497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tottori University |
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Principal Investigator |
ISHIBE Yuichi Department of Anesthesiology and Critical Care Medicine, Tottori University, Faculty of Medicine, Professor and Chairman, 医学部, 教授 (40122014)
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| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Naoto Department of Anesthesiology and Critical Care Medicine, Tottori University, Faculty of Medicine, Instructor, 医学部, 助手 (30032204)
MINAMI Yukari Department of Anesthesiology and Critical Care Medicine, Tottori University, Faculty of Medicine, Research associate, 医学部・附属病院, 助手 (10243403)
NISHIMURA Yukiko Department of Anesthesiology and Critical Care Medicine, Tottori University, Faculty of Medicine, Research associate, 医学部・附属病院, 助手 (50304233)
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| Project Period (FY) |
1999 – 2001
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| Keywords | nitric oxide / exhaled / one lung ventilation / nitric oxide production / thoracic surgery / 肺手術 |
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| Research Abstract |
Laboratory study
NO output is calculated by integrating of the product of exhaled NO concentration and expiratory gas flow. Although the fast response NO analyzer became available, the wave obtained from the analyzer is distorted because of delayed analyzer's response. As the result of application the two-exponential correction to correct the distortion of NO concentration curve, and test by using the human lung model (METI) in various respiratory conditions, we concluded that our real-time exhaled NO measuring system is useful to measure the lung NO concentration and NO output in the limited respiratory conditions.
Clinical study
We compared the effect of one lung ventilation (OLV) on lung NO production between types of thoracic surgery ; lung surgery and non-lung surgery.
1. NO output (VNO) in non-lung surgery group decreased to 66 % of before-OLV after initiation of OLV, but after releasing OLV it recovered to before-OLV level till 20 min after-BLV.
2. Whereas, VNO in lung surgery group immediately decreased to 57 % of before-OLV after initiation OLV and continued low level during OLV. After releasing OLV, VNO was still lower level and did not recover to the baseline value till 20 min after-BLV.
Lower level of VNO in lung surgery group suggests the reduced NO production due to decreased lung volume and effect of surgical manipulation because of prompt recovery of VNO in non-lung surgery group. In conclusion, lung collapse per se for 4-5 hrs during OLV did not influence the NO production from the lung.
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