2000 Fiscal Year Final Research Report Summary
Approach for the establishment of new way of brain resuscutation
| Project/Area Number |
11671524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
MIURA Hitoshi Tokyo Medical University Medicine Lecturer, 医学部, 講師 (50246302)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBASAKI Futoshi Tokyo Merropolitan Institute of Medical Science Department of Moleculae Physiology Director, その他・研究員 (90300954)
WATABANE Yasuo Tokyo Medical University, Medicine, Associate Professor, 医学部, 助教授 (70183720)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Brain ischemia / ischemic neuronal death / mitochondrial dysfunction / calcineurin / immunosuppressant / Cyclosporin A |
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| Research Abstract |
Brain ischemia leads to severe damage in the form of delayed neuronal cell death. We have been investigated the mechanisms of delayed neuronal cell death in terms of the mechanisms of immunosuppressant, such as cyclosporin A (CsA) and FK506. We show here the drastic neuroprotection of the CsA in the forebrain ischemia is not only due to inhibition of calcineurininduced cell death through dephosphorylation of proapoptotic protein Bad, but also due to protection of mitochonorial damage which is caused by the MPT (Mitochondrial Permeability Transition) pore formation through cyclophilin D (CyPD), one of the prolyl cis/trans isomerase family members.
These results shed light on the clinical application and development of new drugs for the treatment of ischemic damage in the brain as well as in the heart and liver.
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[Publications] Wang-HG, Pathan, N., Ethel I, M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., Mckeon, F., Bobo, T., Franke, T,F., and Reed, J,C: "Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD."Science. 284. 339-343 (1999)
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