2000 Fiscal Year Final Research Report Summary
Expression ＆ localization of IGF system in human relapsed prostatic carcinoma
| Project/Area Number |
11671558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hiroshima University |
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Principal Investigator |
USUI Tsuguru Faculty of Medicine, Hiroshima University, Professor, 医学部, 教授 (30034060)
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| Co-Investigator(Kenkyū-buntansha) |
MUTAGUTI Kazuaki University Medical Hospital, Hiroshima University, Research Associate, 医学部・附属病院, 助手 (00314758)
MITA Koji University Medical Hospital, Hiroshima University, Research Associate, 医学部・附属病院, 助手 (70304425)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Prosate carcinoma / IGF / IGFR / IGFBP |
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| Research Abstract |
The insulin-like growth factor (IGF) system, which is composed of two ligands (IGF- I, IGF- II), two receptors (IGFR- I, IGFR- II) and six binding proteins (IGFBP- 1 to - 6), plays an important role in cell biology. The mRNA expression of the IGF system in human prostate cancer tissue was examined. Expression of the IGF system, except IGFBP- 1, was detected in all prostate cancer tissue samples. The expression of IGF- II and IGFBP- 2 significantly correlated with pathologic stage, lymph node metastasis, histologic differentiation and PSA levels after hormone therapy. However, expression of IGF- I significantly lower in advanced patients. In conclusion, in the IGF system, IGF- II and IGFBP- 2 play a role in human prostate cancer progression and their increased expression is a possible candidate for a prognostic indicator in hormone-treated prostate cancer patients.
IGFBP- 7 mRNA, which include in IGFBP superfamily, were expressed in the human BPH derived epithelial and stromal cells by RT-PCR method. However, the expression of IGFBP- 7 mRNA was not detected in human prostate cancer cell line. The results of Northern blot analysis showed the absence of expression in prostate cancer tissues. The inhibitory activity of IGFBP- 7 on cell growth rate might be applicable for the treatment of patients with prostate cancer.
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Research Products
(8 results)
