2001 Fiscal Year Final Research Report Summary
A search for prostate cancer-specific genes
| Project/Area Number |
11671579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kitasato University |
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Principal Investigator |
EGAWA Shin Kitasato Univ. School of Medicine Assistant Professor, 医学部, 講師 (60160347)
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| Co-Investigator(Kenkyū-buntansha) |
KUWAO Sadahito Kitasato Univ. School of Medicine Assistant Professor, 医学部, 助教授 (70137925)
IWAMURA Masatsugu Kitasato Univ. School of Medicine Assistant Professor, 医学部, 講師 (20176564)
UCHIDA Toyoaki Kitasato Univ. School of Medicine Assistant Professor, 医学部, 講師 (70146489)
BABA Shiro Kitasato Univ. School of Medicine Professor, 医学部, 教授 (00051889)
TAKAGAKI Youtaro Kitasato Univ. School of Medicine Professor, 医学部, 教授 (50281324)
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| Project Period (FY) |
1999 – 2001
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| Keywords | Prostate cancer / cancer-specific gene / cloning |
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| Research Abstract |
Introduction of prostate specific antigen (PSA) testing in 1986 has resulted in a dramatic increase in the reported incidence of prostate cancer. Even in Japan, where the prevalence of prostate cancer has long been considered low, the incidence is on the rise: The number of cases is anticipated to increase from 12,783 in 2000 to as many as 26,110 by 2015. Ultrasound-guided biopsy also has facilitated the detection of prostate cancer. This has resulted in stage shift toward more localized diseases. But how this early detection of prostate cancer through PSA testing will affect long-term patient survival is unknown, mainly because we cannot effectively predict at diagnosis the clinical course a tumor will take. Many men with prostate cancer will actually die with it rather than die of it. cDNA library was established from hormone refractory prostate cancer. Differential display analysis indicated a total of 96 differently expressed, cancer-specific bands. Subsequent cloning and screening of cDNA library identified a 361 bp amino acid sequence, which appeared to be identical to Human Lactoferin mRNA. Northern hybridization and RT-PCR of human normal as well as prostatic cancer tissue indicated various patterns of expression of this gene in different human tissues, suggesting potential biological marker. Further study is now underway.
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[Publications] Egawa, S., Matsumoto, K., Suyama, K., Iwamura, M., Kuwao, S. and Baba, S.: "Observations of prostate-specific antigen doubling time in Japanese patients with nonmetastatic prostate cancer"Cancer. 86. 463-9 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Iwamura, M., Wu, W., Muramoto, M., Ohori, M., Egawa, S., Uchida T. and Baba S.: "Parathyroid hormone-related protein is an independent prognostic factor for renal cell carcinoma"Cancer. 86. 1028-34 (1999)
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[Publications] Egawa, S., Takashima, R., Matsumoto, K., Mizoguchi, H., Kuwao, S. and Baba, S.: "Infrequent Involvement of the anterior base in low-risk patients with clinically localized prostate cancer and its possible significance in definitive radiation therapy"Jpn. J. Clin. Oncol.. 30. 126-130 (2000)
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[Publications] Arai, Y., Okubo, K., Terada, T., Matsuta, Y., Egawa, S., Kuwao, S. and Ogura, K.: "Volume-weighted mean nuclear volume predicts tumor biology of clinically organ-confined prostate cancer"Prostate. 46. 134-141 (2001)
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[Publications] Kanoh, Y., Ohtani, N., Mashiko, T., Ohtani, S., Nishikawa, T., Egawa, S., Baba, S., Ohtani, H.: "Levels of a2 macroglobulin can predict bone metastases in prostae cancer"Anticancer Res.. 21(1). 551-556 (2001)
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[Publications] Kanoh, Y., Ohtani, N., Ohara, T., Mashiko, T., Ohtani, S., Egawa, S., Baba, S., Ohtani, H.: "Progression of prostate cancer: diagnostic and prognostic utility of prostate-specific antigen, a2 macroglobulin and their complexes"Oncol Rep.. 8. 515-519 (2001)
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[Publications] Egawa, S., Shimura, S., Irie, A., Kitano, M., Nishiguchi, Y., Kuwao, S., Hayakawa, K., Baba, S.: "Toxicity and health-related quality of life during and after high-does-rate brachytherapy followed by external beam radiotherapy for prostate cancer"Jpn. J. Clin. Oncol.. 31. 541-547 (2001)
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