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2001 Fiscal Year Final Research Report Summary

Angiogenesis in female genital tract cancers and its inhibition

Research Project

Project/Area Number 11671606
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionGifu University

Principal Investigator

FUJIMOTO Jiro  Gifu University Hospital, School of Medicine, Assistant Professor, 医学部・附属病院, 講師 (80199372)

Co-Investigator(Kenkyū-buntansha) TAMAYA Teruhiko  Gifu University, School of Medicine, Professor, 医学部, 教授 (70079870)
Project Period (FY) 1999 – 2001
Keywordsfemale genital tract cancers / metastasis / angiogenisis / angiogenic factors / transcription factors / angiogenic inhibitors / tumor dormancy therapy
Research Abstract

In uterine cervical cancers, the expression of thymidine phosphorylase ( TP ) identified with platelefrderived endothelial cell growth factor ( PD-ECGF ) correlated with microvessel density and patient prognosis. Especially, the increased level of PD-ECGF from the primary tumor to metastatic lymph nodes was recognized as a more sensitive indicator for patient prognosis. Furthermore, serum PD-ECGF can be used a novel tumor marker for advancement of uterine cervical cancers regardless of histopathological types. The transcription factor ets-1 for angiogenesis linked to PD-ECGF and interleukin ( IL )-8 in uterine cervical cancers. As PD-EGGF and ets-1 can be considered to promote growth and secondary spreading via angiogenesis, masked compounds of 5-fluorouracil, substrates of PD-ECGF, and ets-1 inhibitors might be effective on uterine cervical cancers, especially on the metastatic lymph nodes. In ovarian cancers, the expression of vascular endothelial growth factor ( VEGF ) isoform VEGFi … More 65 and ets-1 correlated with patient prognosis, but not with histopathological types and clinical stages, especially in metastatic peritoneal lesions. As VEGF and ets-1 can be considered to promote growth and secondary spreading via angiogenesis, VEGF receptor tyrosine kinase inhibitors, anti-VEGF antibodies and ets-1 inhibitors might be effective on ovarian cancers, especially on metastatic peritoneal lesions. In uterine endometrial cancers, the expression of basic fibroblast growth factor ( bFGF ) correlated with clinical stages. The expression of PD-ECGF and VEGF was partially regulated by sex steroids, and they might grow the early stage of uterine endometrial cancers. IL-8 was induced and reached to the peak level in myometrial invasion, and might work as an angiogenic switch. The expression of ets-1 in well-differentiated uterine endometrial cancers correlated with that of VEGF, and the expression of ets-1 in poorly differentiated uterine endometrial cancers correlated with that of bFGF. Therefore, the target angiogenic factors associated with clinical stages and differentiated grades must be attacked to suppress the specific angiogenesis, which might lead to highly effective treatment with uterine endometrial cancers. Less

  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Fujimoto J., et al.: "Clinical implications of expression of interleulin-8 related to myometrial invasion with angiogenesis in uterine endometrial cancers"Ann. Oncol. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto J., et al.: "Clinical implications of the expression of estrogen receptor alpha and beta in uterine endometrial cancers"Oncology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto J., et al.: "Clinical implication of exprssion of vascular endothelial growth factor in metastatic lesions of ovarian cancers"Br. J. Cancer. 85. 313-316 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto J., et al.: "Steroid receptors and metastatic potential in endometrial cancers"Eur. J. Cancer. 26. 33 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto J., et al.: "The value of platelet-derived endothelial cell growth factor (PD-ECGF) as a novel predictor of advancement of uterine cervical cancers"Cancer Res.. 60. 3662-3665 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto J., et al.: "Clinical implications of expression of interleukin-8 related to angiogenesis in uterine cervical cancers"Cancer Res.. 60. 2632-2635 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto J.: "Encyclopedic Reference of Cancer (Chapter : Cervical cancers)"Springer (Berlin, Germany). 992(192)-992(194) (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto,J., Aoki,I., Khatun,S., Toyoki,H., Tamaya,T.: "Clinical implications of expression of interleukin-8 related to myometrial invasion with angiogenosis in uterine endometrial cancers"Ann Oncol. in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto,J., Sakaguchi,H., Aoki,I., Toyoki,H., Tamaya,T.: "Clinical implications of the expression of estrogen receptor alpha and beta in uterine endometrial cancers"Ann Oncol. in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto,J., Sakaguchi,H., Aoki,I., Khatun,S., Tamaya,T.: "Clinical implication of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers"Br J Cancer. 85. 313-316 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto,J.: "Encyclopedic Reference of cancer ( Chapter Cervical cancer )"Springer ( Berlin, Germany ). 992. 192-194 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto,J., Sakaguchi,H., Aoki,I., Khatun,S., Toyoki,H., Tamaya,T.: "Steroid receptors and metastatic potential in endometrial cancers"J Steroid Biochem Mol Biol. 75. 209-212 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto,J., Sakaguchi,H., Aoki,I., Tamaya,T.: "Steroid receptors and metastatic potential in endometrial cancers"Er J Cancer. 26. S33 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto,J., Sakaguchi,H., Aoki,I., Tamaya,T.: "The value of platelet-derived endothelial cell growth factor (PD-ECGF) as a novel predictor of advancement of uterine cervical cancers"Cancer Res. 60. 3662-3665 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto,J., Sakaguchi,H., Aoki,I., Tamaya,T.: "Clinical implications of expression of interleukin-8 related to angiogenesis in uterine cervical cancers"Cancer Res. 60. 2632-2635 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J., Sakaguchi,H., Hirose,R., Hongwu,W., Tamaya,T.: "Angiogenesis in endometriosis and angiogenic factors"Gynecol Obstet Invest. 48 ( Suppl 1 ). 14-20 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J., Sakaguchi,H., Hirose,R., Hongwu,W., Tamaya,y.: "Clinical implication of expression of platelet-derived endothelial cell growth factor( PD-ECGF ) in metastatic lesions of uterine cervical cancers."Cancer Res. 59. 3041-3044 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J., Sakaguchi,H., Hirose,R., Ichigo,S., Tamaya,T.: "Expression of vascular endothelial growth factor ( VEGF ) and its mRNA in uterine cervical cancers"Br J Cancer. 80. 827-833 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J., Sakaguchi,H., Ichigo,S., Hirose,R., Tamaya,T.: "Expression of platelet-derived endothelial ]cell growth factor ( PD-ECGF ) and its mRNA in uterine cervical cancers"Br J Cancer. 79. 1249-1254 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J., Sakaguchi H, Hirose R, Tamaya,T.: "Expression of platelet-derived endothelial cell growth factor ( PD-ECGF ) related to angiogenesis in ovarian endometriosis"J Clin Endocrinol Metab. 84. 359-262 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J., Sakaguchi,H., Hirose,R., Ichigo,S., Tamaya,T.: "Progestin supress estrogen-induced expression of vascular endothelial growth factor ( VEGF ) subtypes in uterine endometrial cancer cells"Cancer Lett. 141. 63-71 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J., Ichigo,S., Hirose,R., Sakaguchi,H., Tamaya,T.: "Expression of vascular endothelial growth factor ( VEGF ) and its mRNA in uterine endometrial cancers."Cancer Lett. 134. 15-22 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J. Sakaguchi,H., Hirose,R., Ichigo,S., Tamaya,T.: "Biological implication of the expression of vascular endothelial growth factor ( VEGF ) subtypes in ovarian cancers"Cancer. 83. 2527-2533 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J. Sakaguchi,H., Hirose,R., Tamaya,T.: "Sex steroidal regulation of vessel permeability associated with vessel endothelial cadherin ( V-cadheri n )"J Steiroid Biochem Mol Biol. 67. 25-32 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto, J., Ichigo,S., Sakaguchi,H., Hirose R, Tamaya,T.: "Expression of platelet-derived endothelial cell growth factor ( PD-ECGF ) and its mRNA in uterine endometrial cancers."Cancer Lett. 130. 115-120 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J., Ichigo,S., Sakaguchi,H., Hirose,R., Tamaya,T.: "Expression of platelet-derived endothelial cell growth factor ( PD-ECGF ) and its mRNA in uterine endometrium during the menstrual cycle"Mol Hum Reprod. 4. 509-513 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuiimoto,J., Ichigo,S., Sakaguchi,H., Hirose,R., Tamaya,T.: "Expression of platelet-derived endothelial cell growth factor ( PD-ECGF ) and its mRNA in ovarian cancers"Cancer Lett. 126. 83-88 (1998)

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      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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