2001 Fiscal Year Final Research Report Summary
A role of ovarian steroid receptors and cell-cell inter action at the feto-maternal interface in differentiation into decidual cells
| Project/Area Number |
11671646
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Saitama Medical School |
|---|
Principal Investigator |
TAKADA Satoru Saitama Medical School, School of Medicine, Professor, 医学部, 教授 (20143456)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAITOH Maki Saitama Medical School, School of Medicine, assistant, 医学部, 助手 (20301468)
OHKUBO Takashi Saitama Medical School, School of Medicine, assistant, 医学部, 助手 (40271241)
|
|---|
| Project Period (FY) |
1999 – 2001
|
| Keywords | endomentrium / trophoblast / desidualization / cytokine / TNF / thymidine phosphorylase / VEGF / prostaglandin |
|---|
| Research Abstract |
Development of the placenta and decidualizing process is clearly influenced by cells and products of the immune system at the feto-material interface after implantation. Topograplucal and temporal differences in both the growth and differentiation of endometrial elements suggest that local autocrine and paracrine factors modulate the effects of sex steroids. In a previous study, we demonstrated to establish a permanent endometrial stromal fibroblast cell line and a trophoblast cell line. Here we have investigated decidualizing mechanisms and cell-cell interactions at the feto-material interface, using these cell lines.
|
