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2000 Fiscal Year Final Research Report Summary

THE INHIBITORY EFFECT OF FETAL ADENOSINE ON THE PRODUCTION OF TUMOR NECROSIS FACTOR ALPHA.

Research Project

Project/Area Number 11671655
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNIPPON MEDICAL SCHOOL

Principal Investigator

YONEYAMA Yoshio  NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (00201096)

Co-Investigator(Kenkyū-buntansha) SUZUKI Shunji  NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (80291722)
SAWA Rintaro  NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (30267174)
Project Period (FY) 1999 – 2000
Keywordsadenosine / fetus / tumor necrosis factor
Research Abstract

[PURPOSE] The purpose of this study is to evaluate the inhibitory effect of fetal adenosine on production of tumor necrosis factor-α(TNF-α).
[METHOD] We measured plasma adenosine and TNF-α concentrations in the fetuses and preeclamptic women, and then evaluate the relationship between them.
[RESULTS] The elevation of plasma adenosine was associated with the inhibitory effect of production of TNF-α.
[CONCLUSION] This study has suggested that plasma adenosine may play role in the regulation of TNF-α, which eventually dampens to worsen the pathologic conditions of fetuses and preeclamptic women.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Yoneyama Y. et al.: "Plasma adenosine levels and the expression of P-selectin on pldtelets in preeclampsid"Obstet Gynecol. 97. 366-70 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi T. et al: "Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia"Gynecol Obstet Invest. 51. 36-9 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoneyama Y. et al: "Plasma adenosine levels increase in normar Dregnant Women"Am J Obstet Gynecol. 182. 1200-3 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoneyama Y. et al: "Changes in plasma adenosine levels during normae pregnancy"Gynecol Obstet Invest. 50. 145-8 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki S. et al: "Relation ship between serum uric acid and plasma adenosine levels in twin pregnancies"Obstet Gynecol. 96. 507-10 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kijima K. et al: "Effect of tetal enelotoxin administration on plasma PGF2α and cortical levels in total goats"Fetal Diagn Ther. 14. 240-3 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoneyama Y, et al: "Plasma adenosine levels and the expression of P-selectin on platelets in preeclampsia."Obstet Gynecol. 97. 366-70 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeuchi T, et al.: "Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia."Gynecol Obstet Invest. 51. 36-9 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoneyama Y, et al.: "Plasma adenosine levels increase in normal pregnant women."Am J Obstet Gynecol. 182. 1200-3 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoneyama Y, et al.: "Changes in plasma adenosine levels during normal pregnancy."Gynecol Obstet Invest. 50. 145-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki S, Yoneyama Y, et al.: "Relationship between serum uric acid and plasma adenosine levels in twin pregnancies."Obstet Gynecol. 96. 507-10 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kijima K, Yoneyama Y, et al.: "Effect of fetal endotoxin administration on plasma prostaglandin F2-alpha and cortisol levels in late-gestation fetal goats."Fetal Diagn Ther. 14. 240-3 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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