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2000 Fiscal Year Final Research Report Summary

THE MECHANISM OF ISCHEMIC TOLERANCE INDUCTION BY ADENOSINE IN FETAL CARDIAC MUSCLE

Research Project

Project/Area Number 11671656
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNIPPON MEDICAL SCHOOL

Principal Investigator

SAWA Rintaro  NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (30267174)

Co-Investigator(Kenkyū-buntansha) SUZUKI Shunji  NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (80291722)
Project Period (FY) 1999 – 2000
Keywordsadenosine / ischemic preconditioining / 5'-nucleotidase / 心筋 / 5'-nucleotidase
Research Abstract

[PURPOSE] The purpose of this study is to evaluate the effect of adenosine on the induction of ischemic tolerance in fetal cardiac muscle.
[METHOD] We measured cardiac adenosine and 5'-nucleotidase during ischemia with and without ischemic preconditioining in fetal sheep.
[RESULTS] The significant elevation of cardiac adenosine after ischemic preconditioining was associated with an increase of 5'-nucleotidase activity.
[CONCLUSION] This support the powerful effect.of adenosine on the induction of ischemic tolerance in fetal cardiac muscle.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Yoneyama Y et al: "Plasma adenosine levels and the expression of P-selectin on platelets in preeclampsia"Obstet Gynecal. 97. 366-370 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi T et al: "Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia"Gynecol Obstet Invest. 51. 36-39 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki S et al: "Changes in letal plasma adenosine and xanthine sencentrations during letal asphyxia with maternal oxygen administration in erves"Tohoku J Exp Med. 192. 275-281 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoneyama Y et al: "Plasma adenosine levels increase in normal pregnant women"Gynecol Obstet Invest. 50. 145-148 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki S et al: "Relationship between serum uric acid and plasma adenosine levels in twin pregnancies"Obstet Gynecol. 96. 507-510 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoneyama Y, et al: "Plasma adenosine levels and the expression of P-selectin on platelets in preeclampsia."Obstet Gynecol. 97. 366-70 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeuchi T, et al.: "Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia."Gynecol Obstet Invest. 51. 36-9 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki S, et al.: "Changes in fetal plasma adenosine and xanthine concetrations during fetal asphyxia with maternal oxygen administration in ewes."Tohoku J Exp Med. 192. 275-81 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoneyama Y, et al.: "Plasma adenosine levels increase in normal pregnant women."Am J Obstet Gynecol. 182. 1200-3 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoneyama Y, et al.: "Changes in plasma adenosine levels during normal pregnancy."Gynecol Obstet Invest. 50. 145-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki S, Yoneyama Y, et al.: "Relationship between serum uric acid and plasma adenosine levels in twin pregnancies."Obstet Gynecol. 96. 507-10 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kijima K, Yoneyama Y, et al.: "Effect of fetal endotoxin administration on plasma prostaglandin F2-alpha and cortisol levels in late-gestation fetal goats."Fetal Diagn Ther. 14. 240-3 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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