2000 Fiscal Year Final Research Report Summary
THE MECHANISM OF ISCHEMIC TOLERANCE INDUCTION BY ADENOSINE IN FETAL CARDIAC MUSCLE
| Project/Area Number |
11671656
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | NIPPON MEDICAL SCHOOL |
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Principal Investigator |
SAWA Rintaro NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (30267174)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Shunji NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (80291722)
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| Project Period (FY) |
1999 – 2000
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| Keywords | adenosine / ischemic preconditioining / 5'-nucleotidase / 心筋 / 5'-nucleotidase |
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| Research Abstract |
[PURPOSE] The purpose of this study is to evaluate the effect of adenosine on the induction of ischemic tolerance in fetal cardiac muscle.
[METHOD] We measured cardiac adenosine and 5'-nucleotidase during ischemia with and without ischemic preconditioining in fetal sheep.
[RESULTS] The significant elevation of cardiac adenosine after ischemic preconditioining was associated with an increase of 5'-nucleotidase activity.
[CONCLUSION] This support the powerful effect.of adenosine on the induction of ischemic tolerance in fetal cardiac muscle.
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