2000 Fiscal Year Final Research Report Summary
FETAL BRAIN HYPOTHERMIA WITH ADENOSINE
| Project/Area Number |
11671658
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | NIPPON MEDICAL SCHOOL |
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Principal Investigator |
SUZUKI Shunji NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (80291722)
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Rintaro NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (30267174)
YONEYAMA Yoshio NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (00201096)
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| Project Period (FY) |
1999 – 2000
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| Keywords | adenosine / asphyxia / brain temperature / fetus / 胎仔 / 低酸素ストレス |
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| Research Abstract |
[PURPOSE] The purpose of this study is to evaluate the effect of adenosine on brain temperature during asphyxia.
[METHOD] We measured brain temperature during ischemia with and without theophylline (adenosine receptor blocker) and propentofylline (adenosine transport blocker) in fetal sheep.
[RESULTS] Fetal brain temperature relative core decreased significantly during asphyxia with theophylline, while it did not decrease with propentofylline.
[CONCLUSION] Our results suggest the influence of adenosine against cerebral metabolism and blood flow in fetus.
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