2000 Fiscal Year Final Research Report Summary
Sjogren's Syndrome in patients with HTLV-I-associated myelopathy(HAM) :
| Project/Area Number |
11671872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | Nagasaki University |
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Principal Investigator |
IZUMI Masahiro Nagasaki University, School of Dentistry, Assist.Prof,, 歯学部附属病院, 講師 (40212956)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Yukinori Nagasaki University, School of Dentistry, Instructor, 歯学部, 助手 (30295084)
SUMI Misa Nagasaki University, School of Dentistry, Assist.Prof., 歯学部附属病院, 講師 (90284702)
YONETSU Kouichi Nagasaki University, School of Dentistry, Assoc.Prof., 歯学部, 助教授 (70167039)
NAKAMURA Takashi Nagasaki University, School of Dentistry, Prof., 歯学部, 教授 (30172406)
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| Project Period (FY) |
1999 – 2000
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| Keywords | HAM / Salivary gland / dry mouth / HTLV-1 / MRI / Sjogren's syndrome |
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| Research Abstract |
Objective.To characterize imaging features of the major salivary glands in patients with HTLV-I-associated myelopathy(HAM) who were associated with Sjogren's syndrome, and to compare these features with those in HAM-negative patients with Sjogren's syndrome. Subjects and Methods. The study propulation included 31 HAM patients(12 were associated with Sjogren's syndrome), 15 HTLV-I-seropositive/HAM-negative patients with Sjogren's syndrome, and 41 HTLV-I-seronegative patients with Sjogren's syndrome. Separate 20 HAM-negative patients with sicca syndrome only were also studied. Diagnostic imaging(sialography, MR imaging, and sonography) of the salivary glands. labial gland biopsy, Schirmer test, Saxon test and serological tests were performed on these patients. Results. The parotid and submandibular glands in 11(92%) of the 12 HAM patients with Sjogren's syndrome completely lacked the abnormal imaging features characteristic of the disease, while they displayed decreased salivary flow rates at levels similar to those in the HAM-negative patients with Sjogren's Syndrome. The labial glands from the HAM patients with Sjogren's syndrome exhibited significantly lower magnitudes of mononuclear cell aggregation compared with those in the HAM-negative patients with Sjogren's syndrome. In contrast, all HAM-negative patients with Sjogren's syndrome showed abnormal imaging features characteristic of the disease, and the severity in salivary dysfunction correlated well with the imaging findings.
Conclusion. These results suggest that Sjogren's syndrome in HAM patients may at least in part occur via a distinctive mechanism from classical Sjogren's syndrome in HAM-negative patients.
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