Study on oral rehabilitation for the aged who need care, focusing on prophylactic treatment against infection

2000 Fiscal Year Final Research Report Summary

• Project/Area Number: 11671939
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 補綴理工系歯学
• Research Institution: KYUSHU UNIVERSITY
• Principal Investigator: OKIMOTO Kimie Faculty of Dentistry, KYUSHU UNIVERSITY, Assoc.Prof., 大学院・歯学研究院, 助教授 (00037532)
• Co-Investigator(Kenkyū-buntansha): MATSUO Kouichi Faculty of Dentistry, KYUSHU UNIVERSITY, Assis.Prof., 大学院・歯学研究院, 助手 (30229421) ; TERADA Yoshihiro Faculty of Dentistry, KYUSHU UNIVERSITY, Prof., 大学院・歯学研究院, 教授 (30038898)
• Project Period (FY): 1999 – 2000
• Keywords: against infection / aged people who need care / oral candidiasis / miconasole gel / oral care

Research Abstract

Oral rehabilitation is based on "oral care" such as oral hygiene and oral treatment to improve the functions. It includes not only proshodontic treatment with denture and dental cleaning but also continuous treatment to examine and improve oral functions including management for general conditions and. Providers for oral rehabilitation are doctors, care-providers and people who support care. Education of these people and cooperative understanding among them are the key in oral care.
Intractable deglutition pneumonia is a life-threatening disease for the aged people who need care. One of the factors leading to the disease may be invasion of indigonous bacteria in the mouth into the lung. Therefore, gastrointestinal candidiasis including oral candidiasis may influence the general conditions in the aged people who need care. In addition to oral care, establishment of adequate treatment and the prophylaxis against oral candidiasis is the challenge in the future. In the present study, the ag ed inpatients with denture-induced stomatitis were orally treated with an antibacterial agent, 2% miconasole get (Florid) to study the dose, the treatment frequency and the clinical efficacy. The subjects were 23 inpatients who received treatment at a dental department affiliated to a geriatric hospital in Kasuya-county, Fukuoka Prefecture. All patients were clinically suspected of having oral mycosis, which was confirmed by culture analysis. The standard dose of miconasole (10g/day) for two weeks (Treatment 1) was effective in a moment. Mostly, however, the bacteria colony returned to that before treatment within three to four weeks after the treatment. This treatment should be discussed again. In contrast, 2.5g/day of miconasole get for three weeks (Treatment 2) was effective in patients with bacterial colony less than 104 and the efficacy continued at least for one month even after the withdrawal of treatment. However, the Treatment 2 was less effective in the patients with bacterial colony over 105. From these findings, such patients should receive Treatment 1 and then Treatment 2, and for patients who had candidiasis, medication should be done on a regular basis. In addition, long-term medical treatment should be future studied.