2000 Fiscal Year Final Research Report Summary
Experimental study of transport distraction osteogenesis.-Molecular basis of bone metabolism-
| Project/Area Number |
11671977
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokoyo University |
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Principal Investigator |
HIKIJI Hisako Tokyo University, Faculty of medicine, Assistant professor, 医学部・附属病院・分院, 講師 (50292876)
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| Co-Investigator(Kenkyū-buntansha) |
SUSAMI Takafumi Tokyo University, Faculty of medicine, Associate professor, 医学部・附属病院, 助教授 (80179184)
TOYO-OKA Teruhiko Tokyo University, Faculty of medicine, Professor, 保健管理センター, 教授 (00146151)
TAKATO Tuyoshi Tokyo University, Faculty of medicine, Professor, 医学部・附属病院, 教授 (90171454)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Distraction osteogenesis / Bone transport / Nitric oxide |
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| Research Abstract |
Purpose :
Transport distraction osteogenesis, a kind of bone lengthening, has been used to reconstruct missing bones and soft tissues in a segmental deformity. We investigated the applicability of this technique to the arthroplasty of temporomandibular joint (TMJ) with an internal distraction appliance.
Nitric oxide is a principal regulator of bone remodeling systems. We also investigated the effects of nitric oxide on bone formation.
Materials and Methods :
1. The transport disc of the rabbits was advanced 0.9 mm per day for 14 days. After the completion of the lengthening, the rabbits were sacrificed at intervals.
2. The osteoblastic and osteoclastic activities were measured after stimulation by free radical donors, cytokines or growth factors.
Results :
1. More than 8 weeks after the completion of lengthening, the mature cortical bone was reconstructed. A collagenous structure like a cap was formed over the leading edge. This cap may substitute for an articular disc. The new bone has remodeled and resembled the condylar head.
2. Nitric oxide has the bone forming- and bone resorbing- effects.
Conclusion : The bone transport technique is promising for the reconstruction of TMJ.Nitric oxide regulates the bone remodeling system.
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[Publications] Chen J, Wang Y, Wang Y, Nakajima T, Iwasawa K, Hikiji H, Sunamoto M, Choi D, Yoshida Y, Sakaki Y, Toyo-Oka T.: "Autocrine action and its underlying mechanism of nitric oxide on intracellular Ca^<2+> homeostasis in vascular endothelial cells."J.Biol.Chem.. 275. 28739-28749 (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Nakajima T, Okuda Y, Chisaki K, Shin WS, Iwasawa K, Morita T, Matsumoto A, Suzuki S, Yamada N, Toyo-oka T, Nagai R, Omata M.: "Bile acids increase intracellular Ca2+ concentration and nitric oxide production in vascular endothelial cells."Br.J.Pharmacol.. 130. 1457-67 (2000)
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[Publications] Kawada T, Shin WS, Nakaturu Y, Koizumi K, Sakamoto A, Nakajima T, Nakazawa M, Satoh H, Takato T, Ishikawa T, Toyo-oka T.: "Preciseidentification of the gene-Products in hearts after in vivo Gene transfection"Biochem.Biophys.Res.Comun.. 259. 408-13 (1999)
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「研究成果報告書概要(欧文)」より
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