2000 Fiscal Year Final Research Report Summary
Development of the Catalytic Asymmetric Tandem Reactions
| Project/Area Number |
11672112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
IKEDA Shin-ichi Nagoya City University, Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (90254309)
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| Project Period (FY) |
1999 – 2000
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| Keywords | tandem reaction / enantioselectivity / oxazoline / cyclotrimerization |
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| Research Abstract |
We have found a nickel-catalyzed asymmetric multiple-component coupling of enones, alkynes, dimethylzinc, and chlorotrimethylsilane. Interestingly, catalytic systems involving simple monodentate chiral oxazolines, which have been previously used as valuable chiral auxiliaries, were very effective in giving optically active coupling products. In contrast some optically active organophosphorus ligands and bidentate oxazolines, which have been extensively used as ligands for transition metals in asymmetric catalysis, did not give enantioselection. Moreover, we have found an asymmetric cyclotrimerization of enones and alkynes in the presence of a catalytic system of nickel and aluminum. The chiral monooxazoline ligands were also effective in the reaction.
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