| Research Abstract |
In order to contribute to the development of biological study of tetrahydroisoquinolines, amines present in human brain, we have investigated the development of method synthesizing the tetrahydroisoquinolines and their analogs. Some tetrahydroisoquinolines are known to be a toxin which induces Parkinson's disease, while 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline protects the parkinsonism induced by these toxins. The synthesis of these compounds was achieved by applying Pummerer-type reaction. The method consists in the nuceophilic substitution reaction of aromatic ring to the sulfoxide mediated carbocation, was discovered to be highly efficient and widely applicable for synthesizing the variously substituted nitrogen heterocycles, 1, 2, 3, 4-tetrhahydroisoquinoline and benzoazepines.
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