2000 Fiscal Year Final Research Report Summary
MEF plays a role in the pathogenesis of alveolar proteinosis.
| Project/Area Number |
11672174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
KAI Hirofumi Faculty of Pharmaceutical Sciences, Kumamoto University, Associate Professor, 薬学部, 助教授 (30194658)
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| Project Period (FY) |
1999 – 2000
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| Keywords | GM-CSF / MEF / ETS / EPITHELIUM |
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| Research Abstract |
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), a cytokine being expressed in lung epithelial cells, has a major role in the immune, differentiating and inflammatory milieu of airway. We found that ETS-2 positively transactivated GM-CSF expression by protein kinase C pathway and that MEF inhibited ETS-2 binding to DNA consensus sequence (GGAA) in the GM-CSF promoter.
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Research Products
(11 results)
