2000 Fiscal Year Final Research Report Summary
MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNE
| Project/Area Number |
11672223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
医薬分子機能学
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| Research Institution | NATIONAL INSTITUTE OF HEALTH SCIENCES |
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Principal Investigator |
KURIHARA Masaaki 国立医薬品食品衛生研究所, 有機化学部, 第一室長 (20205206)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Naoki 国立医薬品食品衛生研究所, 有機化学部, 部長 (50114674)
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| Project Period (FY) |
1999 – 2000
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| Keywords | enediyne / Bergman reaction / trigger / DNA cleavage |
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| Research Abstract |
It is an interesting challenge to design alternate frameworks and triggering mechanisms, with the goal of producing a stable enediyne which can be activated under controlled conditions, especially in away which directs the cytotoxicity toward a specific pathogen or tissue.
I found simple trigger of cycloaromatization in enediyne system. This enediyne compound were activated by deprotection to cleave DNA.
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[Publications] K.Konno,T.Fujishima,S.Maki,Z.Liu,D.Miura,M.Chokki,S.Ishizuka,K.Yamaguchi,Y.Kan,M.Kurihara,N.Miyata,C.Smith,H.F.DeLuca,H.Takayama: "Synthesis, Biological Evaluation, and Conformational Analysis of A-Ring Diastereomers of 2-Methyl-1,25-dihydroxyvitamin D3 and Its 20-Epimers."J.Wed.Chem.. 43. 4247-4265 (2000)
Description
「研究成果報告書概要(和文)」より
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[Publications] A.Nishikawa,F Furukawa,K.Kasahara,S.Ikezaki,T.Itoh,T.Suzuki,K.Uchida,M.Kurihara,M.Hayashi,N.Miyata,M.Hirose: "Trans-4-hydroxy-2-nonenal, an aldehydic lipid peroxidation product, lacks genotoxicity in lacI transgenic mice."Cancer Lett.. 148. 81-86 (2000)
Description
「研究成果報告書概要(和文)」より
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[Publications] K.Konno, T.Fujishima, S.Maki, Z.Liu, D.Miura, M.Chokki, S.Ishizuka, K.Yamaguchi, Y.Kan, M.Kurihara, N.Miyata, C.Smith, H.F.DeLuca, H.Takayama: "Synthesis, Biological Evaluation, and Conformational Analysis of A-Ring Diastereomers of 2-Methyl-1, 25-dihydroxyvitamin D3 and Its 20-Epimers."J.Med. Chem.. 43. 4247-4265 (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] A.Nishikawa, F.Furukawa, K.Kasahara, S.Ikezaki, T.Itoh, T.Suzuki, K.Uchida, M.Kurihara, M.Hayashi, N.Miyata, M.Hirose: "Trans-4-hydroxy-2-nonenal, an aldehydic lipid peroxidation product, lacks genotoxicity in lacI transgenic mice."Cancer Lett.. 148. 81-6 (2000)
Description
「研究成果報告書概要(欧文)」より
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