2001 Fiscal Year Final Research Report Summary
Plant components modifies the absorption, metabolism and excretion of xenobiotics.
| Project/Area Number |
11680136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食生活
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| Research Institution | University of Shizuoka |
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Principal Investigator |
KINAE Naohide Univ. of Shizuoka, Sch. of Food & Nutr. Sci., Prof., 食品栄養科学部, 教授 (00046286)
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| Co-Investigator(Kenkyū-buntansha) |
HIMOI Kayoko Univ. of Shizuoka, Sch. of Food & Nutr. Sci., Assist. Prof., 食品栄養科学部, 助手 (10162728)
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| Project Period (FY) |
1999 – 2000
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| Keywords | antioxidative potency / antimutaenicity / radical scavenging pote / catechin / sea lettuce / flavonoid / metabolism / adsorption |
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| Research Abstract |
In this study several effective components were isolated from green tea and seaweeds, which show antioxidative, radical scavenging and antimutagenic activities. The modification potency of these components to absorption, metabolism and excretion of xenobiotics were examined in vivo and in vitro.
1. The methanol extract of sea lettuce (Ulva pertusa kjellman) showed antioxidative activity in a dose dependent manner at the range of 0.5 to 5.0 mg/ml. But the potency of water extract was 20 % compared to that of the methanol extract. And radical scavenging activity (ED_50) of the methanol extract was 0.7-1.6 mg/ml. Moreover, the methanol extract inhibited the mutagenicity of MelQx and Trp P-1 which were formed in cooked meat arid fish.
2. Green tea extract suppressed the mutagenicity of nitrosomorpholine (34% in 0.5 mg/plate, 70 % in l.0 mg/plate). Green tea extract also inhibited the formation of nitrosomorpholine in rat oral administered sodium nitrite and morpholine.
3. Several flavonoids containing quercetin and rutin, and food fiber such as chitin, chitosan and cellulose showed the strong adsorption potency to DOT having carcinogenicity and endocrine disrupting activity.
From these data, the intake of plant components including flavonoids may. be beneficial tool to detoxify many xenobiotics by modification of absorption, metabolism and excretion steps.
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[Publications] Arai Y,, Watanabe S., Kimira M., Onodera J., Chida A. Onodera H., Ikeno T., Shimoi K,. Mochizuki R., and Kinae N.: "Dietary intake of Nutrition flavonol, flavone and isoflavone in Japanese women : The quercetin intake inversely associated with the plasma LDL cholesterol concentration"J. Nutrition. 130. 2243-2250 (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Shimoi K., Saka,N., Nozawa,R., Sato,M., Amano I., Nakayama T. and Kinae N.: "Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation"Drug Metab Dispos.. 29(12). 1521-1524 (2001)
Description
「研究成果報告書概要(欧文)」より
