2000 Fiscal Year Final Research Report Summary

Research on the standardigation of design and analysis for in-vitro toxicological experiments

Research Project

Project/Area Number	11680328
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Statistical science
Research Institution	Science University of Tokyo
Principal Investigator	ISAO Yoshimura Science University of Tokyo, Faculty of Engineering Professor, 工学部, 教授 (30010797)
Project Period (FY)	1999 – 2000
Keywords	toxicological expesiment / date analysis / dose-respose relationship / mouse lymphoma assay / transformation assay / synergism
Research Abstract	This study addressed some statistical issues realized in in-vitro toxicological experiments such as the mouse lymphoma assay, transformation assay, and mutagenecity tests.A new method for data analysis was proposed on the mouse lymphoma assay, the result of which was presented and discussed at the workshop held on March 14-16, 2001 at San Diego. The content will be submitted to the "Mutation Research" by four authors Omori, Hayashi, Homma and Yoshimura. The utilization of a Margolin procedure in a validation study on the transformation assay was proposed, the result of which was published on the "Alternatives to Laboratory Animals." A proposal for the design and analysis

(1 results)