2000 Fiscal Year Final Research Report Summary

Gene therapy against model mice with neurodegenerative disorder

Research Project

Project/Area Number	11680800
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Neuroscience in general
Research Institution	Tokyo Metropolitan Institute of Gerontology
Principal Investigator	OGAWARA Midori Tokyo Metropolitan Institute of Gerontology, Department of Molecular Genetics, Assistant, 分子遺伝学部門, 研究助手 (60100111)
Co-Investigator(Kenkyū-buntansha)	白澤卓二財団法人東京都老人総合研究所, 分子遺伝学部門, 室長 (80226323)
Project Period (FY)	1999 – 2000
Keywords	Neurodegeneration / Gene therapy / Isoaspartic acid / PIMT / Knockout mice / Transgenic mice / Adeno virus / Alzheimer's disease
Research Abstract	Protein isoaspartyl methyltransferase (PIMT) has been suggested to play a role in the repair of aged proteins spontaneously incorporated with isoaspartyl residues. Thus the lack of this repair system was expected to show an abnormal accumulation of isoaspartate in the brain of knockout animals with reference to the pathological implications of protein isomerization during aging. Recently, we reported knockout mice lacking the enzymatic activity for PIMT.

(2 results)