2000 Fiscal Year Final Research Report Summary
Gene therapy against model mice with neurodegenerative disorder
| Project/Area Number |
11680800
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
OGAWARA Midori Tokyo Metropolitan Institute of Gerontology, Department of Molecular Genetics, Assistant, 分子遺伝学部門, 研究助手 (60100111)
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| Co-Investigator(Kenkyū-buntansha) |
白澤 卓二 財団法人 東京都老人総合研究所, 分子遺伝学部門, 室長 (80226323)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Neurodegeneration / Gene therapy / Isoaspartic acid / PIMT / Knockout mice / Transgenic mice / Adeno virus / Alzheimer's disease |
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| Research Abstract |
Protein isoaspartyl methyltransferase (PIMT) has been suggested to play a role in the repair of aged proteins spontaneously incorporated with isoaspartyl residues. Thus the lack of this repair system was expected to show an abnormal accumulation of isoaspartate in the brain of knockout animals with reference to the pathological implications of protein isomerization during aging. Recently, we reported knockout mice lacking the enzymatic activity for PIMT.
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