2000 Fiscal Year Final Research Report Summary
Oncogenic viruses and malignant tumors in tropical Africa
| Project/Area Number |
11691214
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Human pathology
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| Research Institution | Nagasaki University |
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Principal Investigator |
TORIYAMA Kan Institute of Tropical Medicine, Nagasaki University, Associate Professor, 熱帯医学研究所, 助教授 (00108359)
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| Co-Investigator(Kenkyū-buntansha) |
ISEKI Masachika Institute of Tropical Medicine, Nagasaki University, Research Associate, 熱帯医学研究所, 助手 (50176252)
ITAKURA Hideyo Institute of Tropical Medicine, Nagasaki University, Professor, 熱帯医学研究所, 教授 (00010512)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Tropical Africa / Epidemiology of malignant tumors / Virus-related oncogene / Kaposi's sarcoma / Cervical cancer / 子宮頸癌 |
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| Research Abstract |
We performed an epidemiological, histological and virological study of malignant tumors in the western part of Kenya, East Africa. Preliminary results are as follows ; 1)AIDS-related Kaposi's sarcoma, which shows disseminated cutaneous papules on the trunk, is increasing in number, 2)The incidence of cervical cancer, which suspected to be related with human papilloma virus(HPV), is increasing among the malignant tumors and a mean age of the patients is becoming younger in AIDS prevalent areas, 3)Hemangioma-like Kaposi's sarcoma is increasing in number histologically, 4)Ultrastructurally we found three types of Kaposi's sarcoma cells, which are differentiating to endothelial cell, pericytes and smooth muscle cells respectively, 5)Human herpes virus(HHV)-8 are found positive among several kaposi's sarcomas and also B lymphocytes around tumors, 6)Almost of cervcal cancers show HPV positive by in situ hybridization, 7)Majority cases of pediatric Hodgkin's disease shows Epstein-Barr virus positive by immunohistochemical methods and in situ hybridization.
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