2001 Fiscal Year Final Research Report Summary
Tissue-bonding organic-inorganic polymer hybrids
| Project/Area Number |
11694162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic materials/Physical properties
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
OSAKA Akiyoshi Faculty of engineering, Okayama University Professor, 工学部, 教授 (20033409)
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| Co-Investigator(Kenkyū-buntansha) |
TSURU Kanji Faculty of engineering, Okayama University Assistant, 工学部, 助手 (50314654)
HAYAKAWA Satoshi Faculty of engineering, Okayama University Lecturer, 工学部, 講師 (20263618)
OHTSUKI Chikara Nara Institute of Science and Technology, Associate Professor, 物質創成科学研究科, 助教授 (00243048)
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| Project Period (FY) |
1999 – 2001
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| Keywords | organic-inorganic hybrid / bioactive / cytocompatibility / apatite / porous material / polydimethylsiloxane / gelatin / γ-glycidoxypropyltrimethoxysilane |
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| Research Abstract |
We investigated some modifications for bioactive organic-inorganic hybrids derived from ploy(dimethylsiloxane) (PDMS,- (SiO(CH_3)_2)_n -), tetraethoxysilane (TEOS), Si (OC_2H_5)_4) and calcium nitrate (Ca(NO_3)_2・4H_2O). (1)Incorporation of TiO_2: PDMS-SiO_2-TiO_2 system couldn't deposit apatite under the simulated body fluid. (2)Porous ORMOSILs: Porous hybrids were prepared by using scurose particle as a porogen. The pore size could be controlled depending on the particle size of the porogen. Porosity of the hybrids was about 90%. The hybrids treated with CaCl_2 solution could deposit apatite within 3 days in the simulated body fluid and also show good cytocompatibility. (3)Hybrids reinforced with colloidal silica: The compressive strength increased by heating. According to dynamic mechanical properties of samples, storage modulus above -50℃ increased by heating. This is related to the increase of PDMS-silica interaction by heating.
A new type of inorganic-organic hybrid materials incorporating gelatin and 3- (glycidoxypropy1) trimethoxysilane (GPSM) was prepared through sol-gel processing. (1)Gelatin-siloxane hybrids: GPSM molecules were grafted to the gelatin chains due to the reactions between the epoxy groups of GPSM and the nucleophilic active groups of gelatin. This process provides inorganic-organic hybrids in which the inorganic component of Si chemically bonded to natural polymer of gelatin with -Si-O-Si- bonds. (2)Incorporation of Ca^<2+>: Ca^<2+> containing gelatin-siloxane hybrids could deposit apatite within 3 days soaking in simulated body fluid. (3)Porous gelatin-siloxane hybrids: The porosity was introduced into these bulk gels by post-gelation soaking and by subsequent freeze-drying. The freezing temperature and pH value of the soaking solutions controlled the porosity and the pore size of the hybrids. The porous hybrids showed good bioactivity and cytocompatibility.
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