2000 Fiscal Year Final Research Report Summary
Molecular mechanism of angiogenesis and clinical application
| Project/Area Number |
11694230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TANAKA Hirotoshi The University of Tokyo Insitute of Medical Science Associate Professor, 医科学研究所, 助教授 (00171794)
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| Co-Investigator(Kenkyū-buntansha) |
牧野 雄一 東京大学, 医科学研究所, 学術振興会特別研究員PD
MORIMOTO Chikao The University of Tokyo Insitute of Medical Science Professor, 医科学研究所, 教授 (30119028)
YUICHI Makino The University of Tokyo Insitute of Medical Science JSPS fellow
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| Project Period (FY) |
1999 – 2000
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| Keywords | ANGIOGENESIS / TRANSCRIPTION FACTOR / MOLECULAR BIOLOGY / VASCULAR DISEASE / PHARMACOLOGY / DRUG DEVELOPMENT / CANCER |
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| Research Abstract |
Hypoxia plays a major role in the regulation of many physiological andpathological processes, and is a critical determinant of the pathogenesis of many disorders, including tumor angiogenesis, ischemic heart disease, and stroke. HIF-1 is a master regulater of hypoxia- dependent gene transcription and the active HIF-1 heterodimer binds DNA at conserved hypoxia response elements to activate transcription of target genes. The mechanism of hypoxia-dependent activation of HIF-1 function is not yet understood. We have demonstrated that the mechanism of signal transduction by HIF-1 is a multistep process. Moreover, we have cloned a cDNA for the novel PAS protein which has intrinsic dominant negative function to HIF-1.
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