| Research Abstract |
This study focused on the tissu-and cell lineage-specific regulation of chromatin structures in hematopoietic cells. There are several transcription factors that bind to the locus control region of hematopoietic-specific genes. To understand their roles, we generated mutant mice lacking the transcription factor genes bach1 or bach2. Further analysis of the phenotypic changes of these mice may pave a way to understand functional link among regulation of transcription, chromatin structures, and cell differentiation. Along these experiments, we also screened for proteins that interact with Bach1 or Bach2 using yeast two hybrid screen. Isolated candidates include proteins that regulate actin structure, transcritional co-regulators, and structural proteins, suggesting their implication in regulation of chromatin structures.
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