2001 Fiscal Year Final Research Report Summary
Gene cleaning and sequence of novel immunosuppressive protein, and its roles on the liver transplantation or cancer metastasis.
| Project/Area Number |
11694304
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
HASHIMOTO Takashi Nagoya City University, Medical School, Associate Professor, 医学部, 助教授 (10094393)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Satoshi Nagoya City University, Medical School, Assistant Professor, 医学部, 講師 (50234935)
MANABE Tadao Nagoya City University, Medical School, Professor, 医学部, 教授 (80127141)
SUZUKI Tatsuya Nagoya City University, Medical School, Research Associate, 医学部, 助手 (00285222)
KUNIMATSU Mitoshi Nagoya City University, Medical School, Assistant Professor, 医学部, 講師 (70145746)
FATAKUCHI Mitsuru Nagoya City University, Medical School, Research Associate, 医学部, 助手 (60275120)
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| Project Period (FY) |
1999 – 2000
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| Keywords | liver transplantation / immunosuppressive protein / cancer metastasis / Indole amine 2,3-deoxygenase (IDO) |
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| Research Abstract |
1. We have succeeded in complete withdrawing of the immuno-suppressive drugs from 2 more cases with living related liver transplantation in our institution. Now, we have totally 3 cases with immuno-tolerance after liver transplantation.
2. Indole amine 2,3-deoxygenase (EDO) which was reported by D.H Munn in 1999, . or novel immuno-suppressive proteins were searched using SELDI- Protein Chips.
3. Inhibitor of EDO was administered to the mice with liver transplantation that had naturally developed immuno-tolerance. However, we could not obtained anovel results
4. We confirmed DNA sequence of rat IDO and induction of IDO in the allogenic orthotopic liver transplantation livers.
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[Publications] Chiang K. C., Goto S., Chen C. L., Ling C. L., Lin Y. C., Pan T. L., Lord R., Lai C. Y., Tseng H. P., Hsu L. W., Lee T. H., Yokoyama H., Kunimatsu M., Chiang Y. C., Hashimoto T.: "Clusterin may be involved in rat liver allograft tolerance"Transplant Immunology. 8. 95-99 (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Tair-Long Pan, Chen-Lung Lin, Chao-Long Chen, Yu-Chun Lin, Gojo, S., Tzong-Hsien Lee, Yu-Hsueh Wang, Roger Lord, Chia-Yun Lai, Li-Weng Tsu, Hui-Peng Tseng, Mei-Ling Wu, Iwashita Y., Kitano S., Kuei-Chen Chiang, Hashimoto T., Sugioka A., Goto S.: "Identification of the indoleamine 2, 3-dioxygenase nucleotide sequence in a rat liver transplant model"Transplant Immunology. 8. 189-194 (2000)
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「研究成果報告書概要(欧文)」より
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[Publications] Hashimoto T., Kondo S., Suzuki T., Nakamura T., Shimizu Y., Nakamura Y., Hayashi S., Zaoh L., Manabe T., Futakuchi M., Shirai T.: "Strategy for ABO-incompatible lizing-related liver transplantation"Transplantation Proceedings. 32. 2104-2106 (2000)
Description
「研究成果報告書概要(欧文)」より
