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2000 Fiscal Year Final Research Report Summary

Development of Intractable Glaucoma Implant Device Using Excimer Laser

Research Project

Project/Area Number 11694316
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionTOKAI UNIVERSITY

Principal Investigator

MURAHARA Masataka  TOKAI UNIVERSITY, FACULTY OF ENGINEERING, PROFESSOR, 工学部, 教授 (40166301)

Project Period (FY) 1999 – 2000
Keywordsexcimer laser / glaucoma / porous fluorocarbon / intraocular pressure / photochemical substitution / capillary phenomenon / hydrophilic functional groups / implant device
Research Abstract

The increased intraocular pressure with aqueous outflow failure causes glaucoma. In healthy human intraocular pressure is maintained at a normal physiological level, between 8 to 18mmHg. When pressure exceeds 21 mmHg, a diagnostic of glaucoma may be predicted.
A new implant designed to pump the aqueous humor and regulate its outflow was created. We investigated several porous PTFE paying special attention to air permeation characteristics. We later reported that porous PTFE films with a 10 μm inner pore diameter could be penetrated by BSS (Balanced Salt Solution) at pressure of 20 mmHg Unfortunately, a PTFE material tends to become fragile with increased pore diameter. In order to circumvent this problem, a material with smaller pore diameters that are easily penetrated by water at low pressure must be developed. We reported elsewhere upon a method of photochemical substitution of hydrophilic or lipophilic groups on fluorocarbon surfaces. The pore inner surface of porous PTFE was made hydrophilic using these techniques that were then applied to liquid separation filters. With this knowledge we were able to develop a device that regulate/control the flow rate of the aqueous humor at a low-pressure differential. BSS cannot penetrate PTFE 3 μm pores even at 300mmHg pressure, but using 193nm photon radiation (1000 shots at 15 mJ/cm^2) transformed the material allowing flow at pressure of 20 mmHg. It was also shown that BSS transmission flow rate was proportional to OH radical substitution density. Experimental results confirmed the processing method as aqueous flow began at 20 mmHg and animal studies showed treated samples to be biocompatible, therefore indicating the potential for this material to be used in intraocular pressure control implants.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] S.Ito and M.Murahara: "Inner Porous Fluoropolymer to Hydrophilic by using UV Light and H_2O Vapor."MRS Symp.Proc.. 554. 51-56 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ito and M.Murahara: "Photo Induced Hydrophilic Treatment of Porous Fluoropolymer Film"Electrochemical Society Proc. 98-23. 458-463 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 村原正隆: "エキシマレーザー/エキシマランプを用いたプラスチックの表面改質"表面化学. 20. 406-413 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Murahara,Y.Sato,J.M.Parel,I.Nose,W.Lee: "Hydrophilic Treatment of Porous PTFE for Intractable Glaucoma Implant Device"Bios 2001 : SPIE Proc. 掲載決定(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.M.Parel,M.Murahara,V.Fernando,I.Nose,W.Lee,E.Fujiwara,H.Tahi,: "Novel glaucoma implant"Bios 2001 International Biomedical Optics Symposium by SPIE. 4254. 30 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 村原正隆: "エキシマレーザーによるプラスチックの表面改質"レーザー研究. 27. 605-611 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 村原正隆: "青鴎"緑内障患者に復員-レーザー技術で手術デバイスに革命を-. 11 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ito and M.Murahara: "Inner Porous Fluolopolymer to Hydrophilic by using UV Light and H2O Vapor"Mat.Res.Soc.Symp.Proc.. Vol.554. 51-56 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Ito and M.Murahara: "Photo Induced Hydrophilic Treatment of Porous Fluoropolymer Film"Electrochemical Society Proc.. Vol.98-23. 458-463 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Murahara: "UV Photon-induced Surface Modification of Plastics by using Eximer Laser/Eximer Lamp"Jounal of The Surface Science Society of Japan. Vol.20 (6). 406-413 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Murahara: "Eximer Laser-Induced Photochemical Surface Modification of Plastics"The Laser Society of Japan. Vol.27 (9). 605-611 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Murahara, Y.Sato, V.Fernandes, P.Milne, I.Nose, W.Lee, J.M.Parel: "Hydrophilic Treatment of Porous PTFE for Intractable Glaucoma Implant Device"SPIE Proc.. To be publish in 2001. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Iizuka, T.Ikegame, I.Nose, W.Lee, P.Chapon, J.M.Parel and M Murahara: "Hydrophilic Treatment of Inner Porous PTFE Implant Devices for Intractable Glaucoma"International Symposium on polymers. 23. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.M.Parel, M.Murahara, V.Fernandoz, I.Nose, W.Lee, E.Fujiwara, H.Tahi, T.Kono, R.Rosa, F.Fantes and G.Flalicinell: Novel Glaucoma Implant ; Bi 2001 International Biomedic Optics Symposium by SPIE. (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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