1999 Fiscal Year Annual Research Report

水溶性カリックスアレーンを用いたC_<60>の水溶化とそのガン治療薬としての評価

Research Project

Project/Area Number	11750749
Research Institution	Kyushu University
Principal Investigator	池田篤志九州大学, 工学研究科, 助手 (90274505)
Keywords	カリックスアレーン / フラーレン / DNA / 光切断 / 包接 / 超分子化学
Research Abstract	現在、生体内の全ての部位に光を照射することが可能となっている。従って、可視光により励起可能なC_<60>を光増感剤として利用することは、光線力学治療法への臨床適応に対し早くから期待されてきた。しかし、C_<60>の水への可溶化の難しさが大きな障壁となってきた。そこで、本研究では超分子化学的な手法を用いて問題解決を行った。今回、本申請者はカチオン性カリックスアレーンにより、C_<60>の水溶化に成功した。このC_<60>錯体によるDNA切断実験を行ったところ、本手法はこれまでの手法に比べ、切断効率が飛躍的に向上した。この結果から、今回用いたカチオン性カリックスアレーンはC_<60>の単なる可溶化剤としてでなく、C_<60>をアニオン性のDNAの近傍に運ぶ担体(キャリアー)としても働くことが示された。以上のように、超分子システムという化学的手法を用いて、DNA切断の高効率化に成功した。

Research Products
(9 results)

All Other

All Publications (9 results)

[Publications] 池田篤志: "Inclusion of [60]Fullerene in a Homooxacalix[3]arene-Based Dimeric Capsule Cross-Linked by a Pd^<II>-Pyridine Interaction"Journal of the American Chemical Society. 121・17. 4296-4297 (1999)
[Publications] 池田篤志: "Water-Soluble [60]Fullerene Cationic Homooxacalix[3]arene Complex Which Is Applicable to Photocleavage of DNA"Chemical Communications. _・18. 1403-1404 (1999)
[Publications] 池田篤志: "A Novel Attempt to Control the Dendrimer Size by Dendrons with a Saccharide"Chemistry Letters. _・9. 929-930 (1999)
[Publications] 沼田宗典: "Dendrimers Can Act as a Host for [60]Fullerene"Tetrahedron Letters. 40・39. 6945-6948 (1999)
[Publications] 川口勝: "Metal-Induced Conformational Changes in Calix[n]arenes Can Control the Electron-Transfer Efficiency between Porphyrine and [60]Fulerene in an On-Off Manner"Tetrahedron Letters. 40・47. 8245-8248 (1999)
[Publications] Zhenlin Zhong: "Triple Linking of Two Homooxacalix[3]arenes Creates Capsule Molecules and Self-Threaded Rotaxanes"Journal of the American Chemical Society. 121・50. 11906-11907 (1999)
[Publications] 池田篤志: "π電子系相互作用の利用―超分子化学への展開を目指して―"化学と工業. 52・5. 582-585 (1999)
[Publications] Shafiqul D.-M.Islam: "Inclusion of [60]Fullerene in a Homooxacalix[3]arene-Based Dimeric Capsule Cross-Linked by a Pd^<II>-Pyridine Interaction"Chemistry Letters. _・1. 4296-4297 (2000)
[Publications] 池田篤志: "Pyridine-appended 5,6-open-aza[60]fulleroid can act as a unique host for alcohols"Journal of Chemical Society,Perkin Transactions 2. (in press).

1999 Fiscal Year Annual Research Report

水溶性カリックスアレーンを用いたC_<60>の水溶化とそのガン治療薬としての評価

Principal Investigator

池田 篤志 九州大学, 工学研究科, 助手 (90274505)

Research Products

[Publications] 池田 篤志: "Inclusion of [60]Fullerene in a Homooxacalix[3]arene-Based Dimeric Capsule Cross-Linked by a Pd^<II>-Pyridine Interaction"Journal of the American Chemical Society. 121・17. 4296-4297 (1999)

[Publications] 池田 篤志: "Water-Soluble [60]Fullerene Cationic Homooxacalix[3]arene Complex Which Is Applicable to Photocleavage of DNA"Chemical Communications. _・18. 1403-1404 (1999)

[Publications] 池田 篤志: "A Novel Attempt to Control the Dendrimer Size by Dendrons with a Saccharide"Chemistry Letters. _・9. 929-930 (1999)

[Publications] 沼田 宗典: "Dendrimers Can Act as a Host for [60]Fullerene"Tetrahedron Letters. 40・39. 6945-6948 (1999)

[Publications] 川口 勝: "Metal-Induced Conformational Changes in Calix[n]arenes Can Control the Electron-Transfer Efficiency between Porphyrine and [60]Fulerene in an On-Off Manner"Tetrahedron Letters. 40・47. 8245-8248 (1999)

[Publications] Zhenlin Zhong: "Triple Linking of Two Homooxacalix[3]arenes Creates Capsule Molecules and Self-Threaded Rotaxanes"Journal of the American Chemical Society. 121・50. 11906-11907 (1999)

[Publications] 池田 篤志: "π電子系相互作用の利用―超分子化学への展開を目指して―"化学と工業. 52・5. 582-585 (1999)

[Publications] Shafiqul D.-M.Islam: "Inclusion of [60]Fullerene in a Homooxacalix[3]arene-Based Dimeric Capsule Cross-Linked by a Pd^<II>-Pyridine Interaction"Chemistry Letters. _・1. 4296-4297 (2000)

[Publications] 池田 篤志: "Pyridine-appended 5,6-open-aza[60]fulleroid can act as a unique host for alcohols"Journal of Chemical Society,Perkin Transactions 2. (in press).

池田篤志九州大学, 工学研究科, 助手 (90274505)

[Publications] 池田篤志: "Inclusion of [60]Fullerene in a Homooxacalix[3]arene-Based Dimeric Capsule Cross-Linked by a Pd^<II>-Pyridine Interaction"Journal of the American Chemical Society. 121・17. 4296-4297 (1999)

[Publications] 池田篤志: "Water-Soluble [60]Fullerene Cationic Homooxacalix[3]arene Complex Which Is Applicable to Photocleavage of DNA"Chemical Communications. _・18. 1403-1404 (1999)

[Publications] 池田篤志: "A Novel Attempt to Control the Dendrimer Size by Dendrons with a Saccharide"Chemistry Letters. _・9. 929-930 (1999)

[Publications] 沼田宗典: "Dendrimers Can Act as a Host for [60]Fullerene"Tetrahedron Letters. 40・39. 6945-6948 (1999)

[Publications] 川口勝: "Metal-Induced Conformational Changes in Calix[n]arenes Can Control the Electron-Transfer Efficiency between Porphyrine and [60]Fulerene in an On-Off Manner"Tetrahedron Letters. 40・47. 8245-8248 (1999)

[Publications] 池田篤志: "π電子系相互作用の利用―超分子化学への展開を目指して―"化学と工業. 52・5. 582-585 (1999)

[Publications] 池田篤志: "Pyridine-appended 5,6-open-aza[60]fulleroid can act as a unique host for alcohols"Journal of Chemical Society,Perkin Transactions 2. (in press).