2000 Fiscal Year Annual Research Report

水溶性カリックスアレーンを用いたC_<60>の水溶化とそのガン治療薬としての評価

Research Project

Project/Area Number	11750749
Research Institution	Kyushu University
Principal Investigator	池田篤志九州大学, 工学研究院, 助手 (90274505)
Keywords	カリックスアレーン / フラーレン / DNA / 光切断 / 包接 / 超分子化学
Research Abstract	現在、生体内の全ての部位に光を照射することが可能となっている。従って、可視光により励起可能なC_<60>を光増感剤として利用することは、光線力学治療法への臨床適応に対し早くから期待されてきた。しかし、C_<60>の水への可溶化の難しさが大きな障壁となってきた。そこで、本研究では超分子化学的な手法を用いて問題解決を行った。今回、本申請者はカチオン性カリックスアレーンにより、C_<60>の水溶化に成功した。このC_<60>錯体によるDNA切断実験を行ったところ、本手法はこれまでの高分子を用いた手法に比べ、切断効率が飛躍的に向上した。この結果から、今回用いたカチオン性カリックスアレーンはC_<60>の単なる可溶化剤としてでなく、C_<60>をアニオン性のDNAの近傍に運ぶ担体(キャリアー)としても働くことが示された。以上のように、超分子システムという化学的手法を用いて、DNA切断の高効率化に成功した。

Research Products
(12 results)

All Other

All Publications (12 results)

[Publications] Munenori Numata et al.: "Properly Assembled Dendrons Can Be Immobilized into Dendrimers by in situ Cross-link"Chemistry Letters. 4. 370-371 (2000)
[Publications] Atsushi Ikeda et al.: "Electrochemical Studies of Calixarene-[60] Fullerene Inclusion Processes"Journal of Inclusion Phenomena and Macrocyclic Chemistry. 37・1/4. 253-258 (2000)
[Publications] Tsukasa Hatano et al.: "Facile Construction of a Ultra-Thin [60] Fullerene Layer from [60] Fullerene-Homooxacalix [3] arene Complexes on Gold Surface"Journal of the Chemical Society, Perkin Transactions 2. 5. 909-912 (2000)
[Publications] Atsushi Ikeda et al.: "Inclusion of [60] Fullerene in a Self-Assembled Homooxacalix [3] arene-based Dimeric Capsule Constructed by a PdII-Pyridine Interaction."Tetrahedron. 56・13. 1825-1832 (2000)
[Publications] Atsushi Ikeda et al.: "A Novel [60] Fullerene-Calixarene Conjugate Which Facilitates Self-Inclusion of the [60] Fullerene Moiety into the Homooxacalix [3] arene Cavity"Journal of European Organic Chemistry. 19. 3287-3293 (2000)
[Publications] Atsushi Ikeda et al.: "Thermodynamic Insight into the Origin of [60] Fullerene Inclusion in Calixarenes and Its Application to a Porphyrin-[60] fullerene Energy Transfer System"Journal of Inclusion Phenomena and Macrocyclic Chemistry. 38・1. 163-170 (2000)
[Publications] Roman Luboradzki et al.: "Sugar-integrated "Supergelators" Which Can Form Organogels with 0.03-0.05% [g ml^<-1>]"Chemistry Letters. 10. 1148-1149 (2000)
[Publications] Atsushi Ikeda et al.: "Design of Homooxacalix [3] arene-Porphyrin Heterocapsules Which Provide Novel Cavities for Molecular Recognition"Chemistry Letters. 10. 1220-1221 (2000)
[Publications] Jean-Francois Eckert et al.: "Polybenzyl ether dendrimers for the complexation of [60] fullerenes"New Journal of Chemistry. 10. 749-758 (2000)
[Publications] Atsushi Ikeda et al.: "Self-Assembled Porphyrin-Based Dimeric Capsule Constructed by a Pd(II)-Pyridine Interaction Which Shows Efficient Guest Inclusion"Organic Letters. 2・23. 3707-3710 (2000)
[Publications] Zhenlin Zhong et al.: "Metal-Mediated Self-Assembly of Pyridylcalixarenes : Prevention of Intramolecular Metal-Chelation is Essential in Constructing Molecular Capsules"Journal of the Organic Chemistry. (in press). (2001)
[Publications] 池田篤志: "3次元空孔を利用した精密分子認識素子の開発-巨大空孔を持つカプセル分子の構築を目指して-"化学と工業. (in press). (2001)

2000 Fiscal Year Annual Research Report

水溶性カリックスアレーンを用いたC_<60>の水溶化とそのガン治療薬としての評価

Principal Investigator

池田 篤志 九州大学, 工学研究院, 助手 (90274505)

Research Products

[Publications] Munenori Numata et al.: "Properly Assembled Dendrons Can Be Immobilized into Dendrimers by in situ Cross-link"Chemistry Letters. 4. 370-371 (2000)

[Publications] Atsushi Ikeda et al.: "Electrochemical Studies of Calixarene-[60] Fullerene Inclusion Processes"Journal of Inclusion Phenomena and Macrocyclic Chemistry. 37・1/4. 253-258 (2000)

[Publications] Tsukasa Hatano et al.: "Facile Construction of a Ultra-Thin [60] Fullerene Layer from [60] Fullerene-Homooxacalix [3] arene Complexes on Gold Surface"Journal of the Chemical Society, Perkin Transactions 2. 5. 909-912 (2000)

[Publications] Atsushi Ikeda et al.: "Inclusion of [60] Fullerene in a Self-Assembled Homooxacalix [3] arene-based Dimeric Capsule Constructed by a PdII-Pyridine Interaction."Tetrahedron. 56・13. 1825-1832 (2000)

[Publications] Atsushi Ikeda et al.: "A Novel [60] Fullerene-Calixarene Conjugate Which Facilitates Self-Inclusion of the [60] Fullerene Moiety into the Homooxacalix [3] arene Cavity"Journal of European Organic Chemistry. 19. 3287-3293 (2000)

[Publications] Atsushi Ikeda et al.: "Thermodynamic Insight into the Origin of [60] Fullerene Inclusion in Calixarenes and Its Application to a Porphyrin-[60] fullerene Energy Transfer System"Journal of Inclusion Phenomena and Macrocyclic Chemistry. 38・1. 163-170 (2000)

[Publications] Roman Luboradzki et al.: "Sugar-integrated "Supergelators" Which Can Form Organogels with 0.03-0.05% [g ml^<-1>]"Chemistry Letters. 10. 1148-1149 (2000)

[Publications] Atsushi Ikeda et al.: "Design of Homooxacalix [3] arene-Porphyrin Heterocapsules Which Provide Novel Cavities for Molecular Recognition"Chemistry Letters. 10. 1220-1221 (2000)

[Publications] Jean-Francois Eckert et al.: "Polybenzyl ether dendrimers for the complexation of [60] fullerenes"New Journal of Chemistry. 10. 749-758 (2000)

[Publications] Atsushi Ikeda et al.: "Self-Assembled Porphyrin-Based Dimeric Capsule Constructed by a Pd(II)-Pyridine Interaction Which Shows Efficient Guest Inclusion"Organic Letters. 2・23. 3707-3710 (2000)

[Publications] Zhenlin Zhong et al.: "Metal-Mediated Self-Assembly of Pyridylcalixarenes : Prevention of Intramolecular Metal-Chelation is Essential in Constructing Molecular Capsules"Journal of the Organic Chemistry. (in press). (2001)

[Publications] 池田篤志: "3次元空孔を利用した精密分子認識素子の開発-巨大空孔を持つカプセル分子の構築を目指して-"化学と工業. (in press). (2001)

池田篤志九州大学, 工学研究院, 助手 (90274505)