2001 Fiscal Year Final Research Report Summary
Establishment of two dimensional bone density distribution imaging technology by an ultrasonic method and development of diagnosis system of osteoporosis
| Project/Area Number |
11792012
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| Research Category |
Grant-in-Aid for University and Society Collaboration
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| Allocation Type | Single-year Grants |
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| Research Field |
Measurement engineering
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| Research Institution | DOSHISHA UNIVERSITY |
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Principal Investigator |
OTANI Takahiko Doshisha University, Faculty of Engineering, Professor, 工学部, 教授 (50066205)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Shinro Kyoto Prefectural University of Medicine, Department of Orthopaedic Surgery, Lecturer, 医学部, 講師 (10226730)
MATSUKAWA Mami DoshishaUniversity, Faculty of Engineering, Associate Professor, 工学部, 助教授 (60288602)
SAKAGUCHI Kazuhiko Doshisha University, Faculty of Engineering, Professor, 工学部, 教授 (40066212)
SUZAKI Takuji HORIBA Ltd, Research and Development Center, Senior Manager, 開発センター, シニアマネージャー(研究職)
TAKADA Masahiko Shiga University of Medical Sciences, Department of Radiology, Assistant, 放射線科, 助手 (10187974)
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| Project Period (FY) |
1999 – 2001
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| Keywords | osteoporosis / cancellous bone / Biot's theory / ultrasonic wave speed / fast wave / slow wave / ultrasonic wave attenuation / acoustical imaging |
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| Research Abstract |
1. Realization of high resolution two dimensional imaging of bone density.
High resolution focusing ultrasonic transmitter and receiver have been developed by use of piezopolymer and the lateral resolution (the ultrasonic beam width) of 1.6 mm has been achieved. Two dimensional imaging of bone density of bovine cancellous bone specimens (in vitro) and the distal end of radius of human subjects (in vivo) has been realized by the novel ultrasonic method using the high resolution ultrasonic transducers with mechanical two dimensional scanning.
2. Quantitative evaluation of the density and the elastic modulus of the trabecular structure of cancellous bone.
(1) The causality between the ultrasonic propagation parameters (propagation speeds and transmitted signal amplitudes of both the fast and slow waves) and the cancellous bone density has been revealed. The novel ultrasonic image is compared with the micro focus X-ray computed tomography image.
(2) The ultrasonic wave propagation path for in
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vivo measurement of cancellous bone is modelized and the density and the elastic modulus of cancellous bone is formulated and expressed by the ultrasonic wave parameters and the electro-acoustic conversion parameters. A new quantitative measurement method of bone density and bone elasticity is proposed.
(3) Computer programs for two dimensional bone density imaging based on the ultrasonic transmitted waves are developed.
3. Analysis of mechanical properties and trabecular structure of cancellous bone.
Three dimensional trabecular structure of cancellous bone has been analyzed and mechanical properties (load characteristics and fracture behavior) have been studied. The mechanical properties of cancellous bone are compared with the bone density value measured by the ultrasonic method.
4. Development and evaluation of tissue-mimicking materials (phantom) and artificial bone.
Ultrasonic wave characteristics of cancellous bone mimicking material (porous honeycomb ceramics) and soft-tissue mimicking material (particle compounded gels) have been studied as standard media (phantom) to calibrate the ultrasonic diagnostic equipment. Artificial bone made by wallastinite ceramics, artificial articular cartilage using PVA-Hydrogel have been studied.
5. Future perspective of the researches.
The next stage of the researches is to establish a bone strength index based on the ultrasonic or elastic properties and on the statistical analysis of huge clinical data. The next stage has already been selected and started as a development project of the Japan Science and Technology Corporation to create a new industry. Less
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