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2001 Fiscal Year Final Research Report Summary

The development of materials for foods and drugs by bio-power of marine microorganisms

Research Project

Project/Area Number 11794013
Research Category

Grant-in-Aid for University and Society Collaboration

Allocation TypeSingle-year Grants
Research Field 生物資源科学
Research InstitutionNagasaki University

Principal Investigator

KODAMA Seiji  Nagasaki University, School of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (00195744)

Co-Investigator(Kenkyū-buntansha) UEDA Hiroshi  Nagasaki University, School of Pharmaceutical Sciences, Professor, 薬学部, 教授 (00145674)
KOBAYASHI Nobuyuki  Nagasaki University, School of Pharmaceutical Sciences, Professor, 薬学部, 教授 (30150329)
WATANABE Masami  Nagasaki University, School of Pharmaceutical Sciences, Professor, 薬学部, 教授 (20111768)
OKAICHI Kumio  Nagasaki University, School of Medicine, Associate Professor, 医学部, 助教授 (80124874)
ODA Tatsuya  Nagasaki University, Faculty of Fisheries, Professor, 水産学部, 教授 (60145307)
Project Period (FY) 1999 – 2001
Keywordsmarine microorganism library / inhibition of melanogenesis / inhibition of tumor cell growth / red tide phytoplankton / active oxygens / mannuronate / inhibition of cell motility / endocrine desruptors
Research Abstract

We constructed a marine microorganism library to find the bacteria that produce materials useful for developing new foods or drugs. This microorganism library provides us the following new results. First, we found two strains of marine bacteria showing the ability to inhibit melanogenesis that is comparable to that of 0. 25 mM ascorbic acid by screening 548 strains of marine bacteria. The bacteria-secreted inhibitors are heat-resistant and show no reductive activity. Then, we also found 24 strains of marine bacteria showing the ability to inhibit the growth of colon cancer cells by screening 2,480 strains of marine bacteria. In addition, we found that mannuronate polymer, one of components of alginate, suppressed the motility of glioblastoma cells having wild-type p53 gene after X-irradiation. Furthermore, we found that galacturonic acid stimulated Chattonella marina and Heterosigna akashiwo to generate increased amounts of O_2-, suggesting that the binding of galacturonic acid to specific sites on the flagellate cell surface may induce the increase of O_2- production. Finally, we established in vitro and in vivo screening systems that were hypersensitive to detect endocrine desruptors in the marine resources.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] J.Kumagai: "Scavenging of long-lived radicals by (-)-epigallocatechin-3-O-gallate and simultaneous suppression of mutation in irradiated mammalian cells"Radiat.Phys.Chem.. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kojio: "Caspase-3 activation and apoptosis induction coupled with the retrograde transcription of shiga toxin : inhibition by brefeldin A"FEMS Immunol.Med.Microbiol. 29. 275-281 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.Ikeda: "Restration of endogenous wild-type p53 activity in a glioblastoma cell with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis"Int.J.Cancer. 94. 35-43 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Oda: "Hemolytic activity of Heterocapsa circularisquama(Dinophyceae) and its possible involvement in shellfish toxicity"J.Phycol.. 37. 509-516 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ueda: "Protein kinase C-mediated inhibition of μ-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral μ-agonist analgesia"J.Neurosci. 21. 2967-2973 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J. Kumagai et al.: "Scavenging of long-lived radicals by (-)-epigallocatechin-3-O-gallate and simultaneous suppression of mutation in irradiated mammalian cells"Radiat. Phys. Chem.. (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Kojio et al.: "Caspase-3 activation and apoptosis induction coupled with the retrograde transcription of shiga toxin : inhibition by brefeldin A."FEMS, Immunol. Med. Microbiol.. 29. 275-281 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J. Ikeda et al.: "Restration of endogenous wild-type p53 activity in a glioblastoma cell with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis"Int. J. Cancer. 94. 35-43 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Oda et al.: "Hemolytic activity of Heterocapsa circularisquama (Dinophyceae) and its possible involvement in shellfish toxicity"J. Phycol.. 37. 509-516 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ueda et al.: "Protein kinase C-mediated inhibition of μ-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral μ-agonist analgesia"J. Neurosci.. 21. 2967-2973 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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