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2001 Fiscal Year Final Research Report Summary

Evaluation of toxicity of environmental chemicals on the basis of their estrogenic activity and DNA-damaging ability and regional risk assessment

Research Project

Project/Area Number 11794019
Research Category

Grant-in-Aid for University and Society Collaboration

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionMie University

Principal Investigator

KAWANISHI Shosuke  Mie University, School of Medicine, Professor, 医学部, 教授 (10025637)

Co-Investigator(Kenkyū-buntansha) OIKAWA Shinji  Mie University, School of Medicine, Lecturer, 医学部, 講師 (10277006)
MURATA Mariko  Mie University, School of Medicine, Lecturer, 医学部, 講師 (10171141)
NAKASHIMA Kunio  Mie University, School of Medicine, Professor, 医学部, 教授 (40022800)
HASHIZUME Kiyoshi  Mie Prefecural Science and Technology Promotion Center, Public Health and Environment Research Division, General Researcher, 保健環境研究所衛生研究グループ, 総括研究員
HIRAKU Yusuke  Mie University, School of Medicine, Assistant Professor, 医学部, 助手 (30324510)
Project Period (FY) 1999 – 2001
KeywordsEnvironmental chemicals / Endocrine disruption / Reproductive toxicity / Carcinogenicity / Genetic damage / Estrogen / Phytoestrogen / Trinitrotoluene
Research Abstract

There has been an alarming concern among general public regarding the reproductive and health hazards of the endocrine disrupting environmental chemicals. Reproductive toxicants are considered to exert their toxicity through not only endocrine disruption but also direct damage to reproductive organs. In fact, a number of carcinogens exhibit reproductive toxicity. Thus, such chemicals may show reproductive toxicity through DNA damage. In the present study, we investigated the role of oxidative DNA damage induced by various environmental chemicals in relation to their carcinogenicity and reproductive toxicity. (1) It is important to clarify the mechanism of carcinogenesis induced by estrogens. Estradiol enhanced proliferation of estrogen-dependent MCF-7 cells at much lower concentrations than its metabolites, catechol estrogens, but did not cause DNA damage. On the other hand, catechol estrogens caused DNA damage at extremely low concentrations. Therefore, catechol estrogens appear to pl … More ay a role in tumor initiation through oxidative DNA damage, whereas estrogens themselves induce tumor promotion by enhancing cell proliferation in estrogen-induced carcinogenesis (Int. J. Cancer, 2001). We found that daidzein, contained in soy beans, and its metabolite, 7 ,3',4'-trihydroxyiosoflavone, may induce carcinogenesis in a similar manner. (2) 2,4,6-Trinitrotoluene (TNT), which is used to produce explosives, has been reported to cause reproductive toxicity and cancer. TNT administration to rats induced a dramatic decrease in the sperm number in the testis and an increase in 8-oxodG formation in the testis and epididymis. A TNT metabolite, induced oxidative damage to ^<32>P-labeled DNA fragments, while TNT itself did not. These findings suggest that TNT induces reproductive toxicity through oxidative DNA damage mediated by its metabolite (Free Radic. Res., in press). We also found that toluene may cause reproductive toxicity in a similar manner (BBRC, 1999). In conclusion, these findings suggest that environmental chemicals may exhibit reproductive toxicity and carcinogenicity through oxidative DNA damage. Less

  • Research Products

    (87 results)

All Other

All Publications (87 results)

  • [Publications] S.Homma-Takeda: "2,4,6-Trinitrotoluene-induced Reproductive Toxicity via Oxidative DNA Damage by its Metabolite"Free Radic Res. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kawanishi: "The role of metals in site-specific DNA damage with reference to carcinogenesis"Free Radic.Biol.Med.. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Murata: "Oxidation of 5'-site guanine at GG and GGG sequences induced by a metabolite of carcinogenic heterocyclic amine PhIP in the presence of Cu(II) and NADH"Carcinogenesis. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ohnishi: "DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis"Cancer Lett.. 178. 37-42 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Hiraku: "Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level : comparison with a spectroscopic assay"Biochim Biophys Acta.. 1570. 47-52 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Hirakawa: "Catechol and Hydroquinone Have Different Redox Properties Responsible for Their Differential DNA-damaging Ability"Chem.Res.Toxicol. 15. 76-82 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ohnishi: "Double Base Lesions of DNA by a Metabolite of Carcinogenic Benzo[a]pyrene"Biochem.Biophys.Res.Commun.. 290. 778-782 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kawanishi: "Mechanism of Guanine-specific DNA Damage by Oxidative Stress and Its Role in Carcinogenesis and Aging"Mutation Res.(Reviews in Mutation Research). 488. 65-76 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kawanishi: "Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds"Free.Radic.Biol.Med.. 31. 108-116 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Hishita: "Caspase-3 Activation by Lysosomal Enzymes in Cytochrome c-independent Apoptosis in a Myelodysplastic Syndrome (MDS)-derived Cell Line P39"Cancer Res.. 61. 2878-2884 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Oikawa: "Site-specific DNA Damage at GGG Sequence by UVA Involves Acceleration of Telomere Shortening"Biochemistry. 40. 4763-4768 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Midorikawa: "Superoxide dismutases enhance H_2O_2-induced DNA damage and alter its site specificity"FEBS Lett.. 495. 187-190 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Murata: "Acrylonitril Enhances H_2O_2-Mediated DNA Damage via Nitrogen-Centered Radical Formation"Chem.Res.Toxicol.. 14. 1421-1427 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Oikawa: "Site Specificity and Mechanism of Oxidative DNA Damage Induced by Carcinogenic Catechol"Carcinogenesis. 22. 1239-1245 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Murata: "Mechanism of Oxidative DNA Damage Induced by Carcinogenic 4-Aminobiphenyl"Free Radic.Biol Med.. 30. 765-773 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Murata: "Requirement of Glutathione and Cysteine in Guanine-specific Oxidation of DNA by Carcinogenic Potassium Bromate"Chem.Res.Toxicol.. 14. 678-685 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Sakano: "Hydroxyurea Induces Site-specific DNA Damage via Formation of Hydrogen Peroxide and Nitric Oxide"Jpn.J.Cancer Res.. 92. 1166-1174 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Ohkuma: "Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II), cytochrome P450 reductase and NADPH"Free.Radic.Res.. 34. 595-604 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ohnishi: "Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazobenzene"Jpn.J.Cancer Res. 92. 23-29 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Sakano: "Mechanism of Metal-mediated DNA Damage Induced by Metabolites of Carcinogenic 2-Nitropropane"Mutat.Res.. 479. 101-111 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ohnishi: "Oxidative DNA Damage by an N-Hydroxy Metabolite of the Mutagenic Compound Formed from Norharman and Aniline"Mutat.Res.. 494. 63-72 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Midorikawa: "Protective Effect of Phytic Acid on Oxidative Damage with Reference to Cancer Chemoprevention"Biochem.Biophys.Res.Commun. 288. 552-557 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Ohkuma: "Oxidative DNA Damage Induced by a Metabolite of Carcinogenic o-Anisidine : Enhancement of DNA Damage and Alteration in its Sequence-Specificity by Superoxide Dismutase"Arch Biochem.Biophys.. 389. 49-56 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ohnishi: "Oxidative DNA Damage by a Metabolite of Carcinogenic 1-Nitropyrene"Biochem.Biophys.Res.Commun.. 280. 48-52 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Hiraku: "Amplification of Bleomycin-induced DNA Cleavage at Cytosine Residues 3' to GGG Sequences by Pyrrole Triamide"Biochem.Pharmacol.. 61. 351-356 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Hiraku: "Catechol Estrogens Induce Oxidative DNA Damage and Estradiol Enhances Cell Proliferation"Int.J.Cancer. 92. 333-337 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 及川伸二: "環境因子による酸化的DNA損傷とがん、老化"Environ.Mut.Res.Commun.. 23. 207-213 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Murata: "Oxidative DNA Damage by Vitamin A and its Derivative via Superoxide Generation"J.Biol.Chem.. 275. 2003-2008 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kawanishi: "Amplification of Pepleomycin-mediated DNA Cleavage and Apoptosis by Unfused Aromatic Cations"Biochemistry. 39. 13210-13215 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Hiraku: "Distinct Mechanisms of Guanine-specific DNA Photodamage Induced by Nalidixic Acid and Fluoroquinolone Antibacterials"Arch.Biochem.Biophys.. 382. 211-218 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ohnishi: "Copper-dependent DNA Damage Iinduced by Hydrazobenzene, an Azobenzene Metabolite"Free Radic.Res.. 32. 469-478 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Midorikawa: "DNA Damage by Dimethylformamide : Role of Hydrogen Peroxide Generated During Degradation"Chem.Res.Toxicol.. 13. 309-315 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Murata: "Mechanism of Oxidative DNA Damage Induced by Carcinogenic Allyl Isothiocynate"Free Radic.Biol.Med.. 28. 797-805 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Tada-Oikawa: "Determination of DNA damage, peroxide generation, mitochondrial membrane potential, and caspase-3 activity during ultraviolet A-induced apoptosis"Methods Enzymol.. 319. 331-342 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Ito: "Sequence Specificity of Ultraviolet A-induced DNA Damage in the Presence of Photosensitizer"Methods Enzymol.. 319. 417-427 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Oikawa: "Mechanism of Acceleration of Telomere Shortening by UVA"Photomedicine and Photobiology. 22. 47-48 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Yamashita: "Distinct Mechanisms of DNA Damage in the Process of Apoptosis Induction by Quercetin and Luteolin"Free Radic.Res.. 33. 623-633 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Murata: "Oxidative DNA Damage by Minor Metabolites of Toluene May Lead to Carcinogenesis and Reproductive Dysfunction"Biochem.Biophys.Res.Commun.. 261. 478-483 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Ohkuma: "Oxidative DNA Damage by a Metabolite of Carcinogenic and Reproductive Toxic Nitrobenzene in the Presence of NADH and Cu(II)"Biochem.Biophys.Res.Commun.. 257. 555-560 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kawanishi: "DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (review)"Int.J.Mol.Med.. 3. 169-174 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 及川伸二: "外因性内分泌攪乱化学物質(環境ホルモン)問題の現状と今後"労働の科学. 54. 340-344 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山下成人: "環境エストロゲンと内分泌攪乱"臨床検査. 43. 1375-1382 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 川西正祐: "中毒学 -基礎・臨床・社会医学-"朝倉書店 (荒記俊一 編). 408 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kawanishi: "Curr Probl Dermatol.Vol.29 Oxidants and Anitoxidants in Cutaneous Biology"Karger(J.Thiele and P.Elsner eds.). 193 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 川西正祐: "別冊 医学のあゆみ 酸化ストレス-フリーラジカル医学生物学の最前線"医歯薬出版 (吉川敏一 編). 326 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kawanishi: "Free Radicals in Chemistry, Biology and Medicine"OICA International (T.Yoshikawa, S.Toyokuni, Y.Yamamoto and Y.Naito, eds.). 518 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Homma-Takeda S, Hiraku, Y. Ohkuma Y. Oikawa S, Murata M, Ogawa K, Iwamuro T, Li S, Sun GF, Kumagai Y, Shimojo N, Kawanishi S.: "2,4,6-Trinitrotoluene-induced Reproductive Toxicity via Oxidative DNA Damage by its Metabolite."Free Radic Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawanishi S, Hiraku Y, Murata M, Oikawa S.: "The role of metals in site-specific DNA damage with reference to carcinogenesis."Free Radic. Biol. Med.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata M, Kawanishi S.: "Oxidation of 5'-site guanine at GG and GGG sequences induced by a metabolite of carcinogenic heterocyclic amine PhIP in the presence of Cu(II) and NADH."Carcinogenesis. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohnishi S, Murata M, Kawanishi S.: "DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis."Cancer Lett.. 178(1). 37-42 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiraku Y, Murata M, Kawanishi S.: "Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level : comparison with a spectroscopic assay."Biochim Biophys Acta.. 1570(1). 47-52 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirakawa K, Oikawa S, Hiraku Y, Hirosawa I, Kawanishi S.: "Catechol and hydroquinone have different redox properties responsible for their differential DNA-damaging ability."Chem Res Toxicol.. 15(1). 76-82 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohnishi S, Kawanishi S.: "Double base lesions of DNA by a metabolite of carcinogenic benzo[a]pyrene."Biochem Biophys Res Commun.. 290(2). 778-782 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawanishi S, Hiraku Y, Oikawa S.: "Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging."Mutat Res.. 488(1). 65-76 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawanishi S, Inoue S, Oikawa S, Yamashita N, Toyokuni S, Kawanishi M, Nishino K.: "Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds."Free Radic Biol Med.. 31(1). 108-116 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hishita T, Tada-Oikawa S, Tohyama K, Miura Y, Nishihara T, Tohyama Y, Yoshida Y, Uchiyama T, Kawanishi S.: "Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39."Cancer Res.. 61(7). 2878-2884 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oikawa S, Tada-Oikawa S, Kawanishi S.: "Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening."Biochemistry. 40(15). 4763-4768 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Midorikawa K, Kawanishi S.: "Superoxide dismutases enhance H_2O_2-induced DNA damage and alter its slte specificity."FEBS Lett.. 495(3). 187-190 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata M, Ohnishi S, Kawanishi S.: "Acrylonitrile enhances H_2O_2-mediated DNA damage via nitrogen-centered radical formation."Chem Res Toxicol.. 14(10). 1421-1427 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oikawa S, Hirosawa I, Hirakawa K, Kawanishi S.: "Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol."Carcinogenesis. 22(8). 1239-1245 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata M, Tamura A, Tada M, Kawanishi S.: "Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl."Free Radic Biol Med.. 30(7). 765-773 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata M, Bansho Y, Inoue S, Ito K, Ohnishi S, Midorikawa K, Kawanishi S.: "Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate."Chem Res Toxicol.. 14(6). 678-685 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakano K, Oikawa S, Hasegawa K, Kawanishi S.: "Hydroxyurea Induces Site-specific DNA Damage via formation of hydrogen peroxide and nitric oxide."Jpn J Cancer Res.. 92(11). 1166-1174 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohkuma Y, Hiraku Y, Kawanishi S.: "Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II), cytochrome P450 reductase and NADPH."Free Radic Res.. 34(6). 595-604 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohnishi S, Murata M, Degawa M, Kawanishi S.: "Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazobenzene."Jpn J Cancer Res.. 92(1). 23-29 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakano K, Oikawa S, Murata M, Hiraku Y, Kojima N, Kawanishi S.: "Mechanism of metal-mediated DNA damage induced by metabolites of carcinogenic 2-nitropropane."Mutat Res.. 479(1-2). 101-111 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohnishi S, Murata M, Oikawa S, Totsuka Y, Takamura T, Wakabayashi K, Kawanishi S.: "Oxidative DNA damage by an N-hydroxy metabolite of the mutagenic compound formed from norharman and aniline."Mutat Res.. 494(1-2). 63-72 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Midorikawa K, Murata M, Oikawa S, Hiraku Y, Kawanishi S.: "Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention."Biochem Biophys Res Commun.. 288(3). 552-557 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohkuma Y, Kawanishi S.: "Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine : enhancement of DNA damage and alteration in its sequence specificity by superoxide dismutase."Arch Biochem Biophys.. 389(1). 49-56 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohnishi S, Murata M, Fukuhara K, Miyata N, Kawanishi S.: "Oxidative DNA damage by a metabolite of carcinogenic 1-nitropyrene."Biochem Biophys Res Commun.. 280(1). 48-52 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiraku Y, Oikawa S, Kuroki K, Sugiyama H, Saito I, Kawanishi S.: "Amplification of bleomycin-induced DNA cleavage at cytosine residues 3' to GGG sequences by pyrrole triamide."Biochem Pharmacol.. 61(3). 351-356 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiraku Y, Yamashita N, Nishiguchi M, Kawanishi S.: "Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation."Int J Cancer. 92(3). 333-337 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawanishi S, Hiraku Y.: "Sequence-specific DNA damage induced by UVA radiation in the presence of endogenous and exogenous photosensitizers."Curr Probl Dermatol.. 29. 74-82 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata M, Kawanishi S.: "Oxidative DNA damage by vitamin A and its derivative via superoxide generation."J Biol Chem.. 275(3). 2003-2008 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawanishi S, Oikawa S, Kawanishi M, Sugiyama H, Saito I, Strekowski L, Wilson WD.: "Amplification of pepleomycin-mediated DNA cleavage and apoptosis by unfused aromatic cations."Biochemistry. 39(43). 13210-13215 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiraku Y, Kawanishi S.: "Distinct mechanisms of guanine-specific DNA photodamage induced by nalidixic acid and fluoroquinolone antibacterials."Arch Biochem Biophys.. 382(2). 211-218 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohnishi S, Murata M, Oikawa S, Hiraku Y, Kawanishi S.: "Copper-dependent DNA damage induced by hydrazobenzene, an azobenzene metabolite."Free Radic Res.. 32(6). 469-478 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Midorikawa K, Murata M, Oikawa S, Tada-Oikawa S, Kawanishi S.: "DNA damage by dimethylformamide : role of hydrogen peroxide generated during degradation."Chem Res Toxicol.. 13(4). 309-315 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata M, Yamashita N, Inoue S, Kawanishi S.: "Mechanism of oxidative DNA damage induced by carcinogenic allyl isothiocyanate."Free Radic Biol Med.. 28(5). 797-805 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tada-Oikawa S, Oikawa S, Kawanishi S.: "Determination of DNA damage, peroxide generation, mitochondrial membrane potential, and caspase-3 activity during ultraviolet A-induced apoptosis."Methods Enzymol.. 319. 331-342 (2000)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Ito K, Kawanishi S.: "Sequence specificity of ultraviolet A-induced DNA damage in the presence of photosensitizer."Methods Enzymol.. 319. 417-427 (2000)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Oikawa S, Tada-Oikawa S, Kawanishi S.: "Mechanism of Acceleration of Telomere Shortening by UVA."Photomedicine and Photobiology. 22. 47-48 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamashita N, Kawanishi S.: "Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin."Free Radic Res.. 33(5). 623-633 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata M, Tsujikawa M, Kawanishi S.: "Oxidative DNA damage by minor metabolites of toluene may lead to carcinogenesis and reproductive dysfunction."Biochem Biophys Res Commun.. 261(2). 478-483 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohkuma Y, Kawanishi S.: "Oxidative DNA damage by a metabolite of carcinogenic and reproductive toxic nitrobenzene in the presence of NADH and Cu(II)."Biochem Biophys Res Commun.. 257(2). 555-560 (1999)

    • Description
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  • [Publications] Kawanishi S, Hiraku Y, Inoue S.: "DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (review)."Int J Mol Med.. 3(2). 169-174 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawanishi S, Oikawa S, Hiraku, Y.: "Role of Sequence-specific DNA Damage in Carcinogenesis and Aging. In : Free Radicals in Chemistry, Biology and Medicine, (T. Yoshikawa, S. Toyokuni, Y. Yamamoto and Y. Naito, eds. )"OICA International, London. 85-91 (2000)

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Published: 2003-09-17  

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