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2000 Fiscal Year Final Research Report Summary

Establishment of International Hibakusha's Medical Information Network.

Research Project

Project/Area Number 11794020
Research Category

Grant-in-Aid for University and Society Collaboration

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionNAGASAKI UNIVERSITY

Principal Investigator

YAMASHITA Shunichi  Departrnent of Molecular Medicine, Atomic Bomb Disease Institute, NAGASAKI UNIVERSITY Professor, 医学部, 教授 (30200679)

Co-Investigator(Kenkyū-buntansha) YAMANOBE Yuji  Department of Medical Informatics, NAGASAKI UNIVERSITY Lecturer, 医学部・附属病院, 講師 (40284690)
OHTSURU Akira  Dept. of Molecular Med., Atomic Bomb Disease Institute, NAGASAKI UNIVERSITY Associate Professor, 医学部, 助手 (00233198)
NAMBA Hiroyuki  Dept. of Molecular Med., Atomic Bomb Disease Institute,NAGASAKI UNIVERSITY Associate Professor, 医学部, 助教授 (80237635)
TAKAMURA Noboru  Department of Preventive Medicine & Health Promotion, NAGASAKI UNIVERSITY Lecturer, 医学部, 講師 (30295068)
Project Period (FY) 1999 – 2000
KeywordsRadiation / Hibakusha / Telemedicine / International Cooperation / Semipalatinsk / Molecular Diagnoses / Molecular Pathology / Chernobyl
Research Abstract

Epidemiological studies including Atomic Bomb survivors and children around Chernobyl suggest that thyroid gland as well as bone marrow seem to be one of the most sensitive organs to the carcinogenic effects of external radiation. Since 1999, the satellite-based telemedicine has been successfully introduced between Nagasaki and Gomel in Belarus, and between Nagasaki and Semipalatinsk in Kazakhstan, respectively. The results of medical assistance are highly evaluated because of increased number of early diagnosis of thyroid cancers and great contribution on surgical treatment for such patients. The exchange programs of researches are aiso useful not only to improve infrastructure of medical knowledge but also to promote mutual understanding among these countries. Now our telemedicine program is undertaken by WHO-SMHF Health Telematics using internet-based telecommunication. Concerning the operated childhood thyroid cancer tissues around Chernobyl, gene rearrangements of ret/PTC subtypes have been reported as a common genetic damage of radiation-associated thyroid cancer. The post-Chernobyl Thyroid Tissues, Nucleic Acids and Data Bank have been just established at the three countries (Minsk, Kiev and Obninsk) as an internationally supported cooperative research resource (http://www.wrl.cam.ac.uk/nisctb), which is now expected to avoid direct competition for limited tissue resources. Owing to such international cooperation, the infrastructure of scientific research on radiation-associated human thyroid carcinogenesis has been established. Finally the two-years project has now paved how we could cooperate and contribute from Nagasaki to the worid but there is a room for improvement, vice verse, how Nagasaki is activated from the world.

  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] 山下俊一, 他: "事故の医学的影響、チェルノブイリ事故から15年-私たちが学んだこと"日本原子力学会誌. 44・2. 186-193 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Takamura, et al.: "A new century of international telemedicine for radiation-exposed victims in the world"J Clin Endocrinol Metab. 86. 4000 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山下俊一: "放射線による甲状腺癌"医学のあゆみ. 197・3. 225-227 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] O.Fofanova, et al.: "MR imaging of the pituitary gland in children with confrential combined pituitary hormone deficiency associated with PROP 1 mutations"Am J Roentogenol. 174. 555-559 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Sautin, et al.: "Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation"Thyroid. 10・9. 734-740 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山下俊一: "チェルノブイリ原発事故後の健康問題"臨床検査. 44・6. 665-667 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Shklyaev, et al.: "Sage transcript profiles in cultured human fetal fibroblasts, WI-38"DNA Sequence. 11・3-4. 281-286 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Takamura, et al.: "Chernobyl-induced radiophobia and the incidence of tuberculosis"Lancet. 356. 257 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nagayama, et al.: "Inhibition of angiogenesis and tumorigenesis, and induction of dormancy by p53 in a p53-null thyroid carcinoma cell line in vivo"Anticancer Res. 20. 2723-2728 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] G.A.Thomas, et al.: "Thyroid tumor banks"Science. 289・5488. 2283 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nagayama, et al.: "Identification of the sites of asparagine-linked glycosylation on the human thyrotropin receptor and studies on their role in receptor function and expression"J Pharmacol Exp Ther. 295・1. 404-409 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nagayama, et al.: "Adenovirus-mediated tumor suppressor p53 gene therapy for anaplastic thyroid carcinoma in vitro and in vivo"J Clin Endocrinol Metab. 85・11. 4081-4086 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] V.Braiden, et al.: "Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter"Human Gene Therapy. 11・10. 2453-2463 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Rogounovitch, et al.: "Congenital erythropoietic porphyria : a novel homozygous mutation in a Japanese patient"J Invest Dermatol. 15. 1156 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 難波裕幸, 他: "2)放射線と甲状腺癌"臨床検査. 43・11. 1425-1432 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nagayama, et al.: "Enhanced efficacy of transcriptionally targeted suicide gene/prodrug therapy for thyroid carcinoma with the Cre-loxP system"Cancer Res. 59. 3049-3052 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Belugin, et al.: "Developmental and hormonal regulation of thermosensitive neuron potential activity in rat brain"Thyroid. 9. 837-843 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] G.Alipov, et al.: "Ret/PTC rearrangement in thyroid cancer around Semipalatinsk nuclear testing sites"Lancet. 354. 1528-1529 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Yamashita, et al.: "Satellite communication and medical assistance for thyroid disease diagnosis from Nagasaki to Chernobyl"Thyroid. 9. 969 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Takamura, et al.: "Gene analysis of PROP1 in dwarfism with combined pituitary hormone deficiency"Growth Horm IGF Res. 9. 12-17 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ito, et al.: "Expression of the axl receptor tyrosine kinase in human thyroid carcinoma"Thyroid. 9. 563-567 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nagayama, et al.: "Role of asparagine-linked oligosaccharides in protein folding, membrane targeting, and thyrotropin and autoantibody binding of the human thyrotropin receptor"J Biol Chem. 273. 33423-33428 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Hara, et al.: "Thyrotropin regulates c-Jun N-terminal kinase(JNK) activity through two distinct signal pathways in human thyroid cells"Endocrinology. 140. 1724-1730 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Yamashita, et al.: "The Genetics of Complex Thyroid Diseases"Springer. 222 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Yokota, et al.: "MEDINFO 2001"Amsterdam. 1595 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Yamashita, et al.: "Radiation and Thyroid Cancer"World Scientific. 543 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N. Takamura,et al.: "A new century of international telemedicine for radiation-exposed victims in the world."J Clin Endocrinol Metab. 86. 4000 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] O. Fofanova,et al.: "MR imaging of the pituitary gland in children with confrential combined pituitary hormone deficiency asscciated with PROP 1 mutations."Am J Roentogenol. 174. 555-559 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Sautin,et al.: "Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation."Thyroid. 10(9). 733-740 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Shklyaev,et al.: "Sage transcript profiles in cultured human fetal fibroblasts, WI-38."DNA Sequence. 11(3-4). 281-286 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Takamura,et al.: "Chemobyl-induced radiophobia and the incidence of tuberculosis."Lancet. 356. 257 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Nagayama,et al.: "Inhibition of angiogenesis and tumorigenesis, and induction of dormancy by p53 in a p53-null thyroid carcinoma cell line in vivo."Anticancer Res. 20. 2723-2728 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] G. A. Thomas,et al.: "Thyroid tumor banks"Science. 289(5488). 2283 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Nagayama,et al.: "Identification of the sites of asparagine-linked glycosylation on the human thyrotropin receptor and studies on their role in receptor function and expression."J Pharmacol Exp Ther. 295(1). 404-409 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Nagayama,et al.: "Adenovirus-mediated tumor suppressor p53 gene therapy for anaplastic thyroid carcinoma in vitro and in vivo."J Clin Endocrinol Metab. 85(11). 4081-4086 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] V. Braiden,et al.: "Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter."Human Gene Therapy. 11(10). 2453-2463 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Rogounovitch,et al.: "Congenital erythropoietic porphyria : a novel homozygous mutation in a Japanese patient."J Invest Dermatol. 15. 1156 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Nagayama,et al.: "Enhanced efficacy of transcriptionally targeted suicide gene/prodrug therapy for thyroid carcinoma with the Cre-loxP system."Cancer Res. 59. 3049-3052 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Belugin,et al.: "Developmental and hormonal regulation of thermosensitive neuron potential activity in rat brain."Thyroid. 9. 837-843 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] G. Alipov,et al.: "Ret/PTC rearrangement in thyroid cancer around Semipalatinsk nuclear testing sites."Lancet. 354. 1528-1529 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Yamashita,et al.: "Satellite communication and medical assistance for thyroid disease diagnosis from Nagasaki to Chemobyl."Thyroid. 9. 969 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Takamura,et al.: "Gene analysis of PROP1 in dwarfism with combined pituitary hormone deficiency."Growth Horm IGF Res. 9. 12-17 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Ito,et al.: "Expression of the axl receptor tyrosine kinase in human thyroid carcinoma."Thyroid. 9. 563-567 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Nagayama,et al.: "Role of asparagine-linked oligosaccharides in protein folding, membrane targeting, and thyrotropin and autoantibody binding of the human thyrotropin receptor."J Biol Chem. 273. 33423-33428 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Hara,et al.: "Thyrotropin regulates c-Jun N-terminal kinase (JNK) activity through two distinct signal pathways in human thyroid cells."Endocrinology. 140. 1724-1730 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Yamashita,et al.: "Lessons from Chemobyl ; need for molecular epidemiology of childhood thyrold cancer. The Genetics of Complex Thyroid Diseases T. Akamizu, M. Kasuga, T. F. Davis (eds)"Springer. 184-197 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Yokota,et al.: "Evaluation of a telemedicine system for supporting thyroid disease diagnosis. MEDlNFO 2001 V. Patel, et al. (eds)"Amsterdam. 866-869 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Yamashita,et al.: "Monitoring and prevention of the development of thyroid carcinoma in a population exposed to radiation. Radiation and Thyroid Cancer G. Thomas, A. Karaglou, E. D. (ed s)"Williams World Scientific. 369-376 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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