2000 Fiscal Year Final Research Report Summary
Study of brain plasticity during intensive training in stroke patients
| Project/Area Number |
11835025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Institution | Kagoshima University |
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Principal Investigator |
ETOH Seiji Faculty of Medicine, Kagoshima University, Research Associate, 医学部, 助手 (70295244)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Nobuyuki Faculty of Medicine, Kagoshima University, Professor, 医学部, 教授 (40041454)
OGATA Atuko University Hospital, Faculty of Medicine, Kagoshima University, Research Associate, 医学部・附属病院, 助手 (40305123)
KAWAHIRA Kazumi Faculty of Medicine, Kagoshima University, Associate Professor, 医学部, 助教授 (20117493)
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| Project Period (FY) |
1999 – 2000
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| Keywords | stroke / transcranial magnetic stimulation / intensive training / hemiplegia |
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| Research Abstract |
The mechanisms which leads to recovery of motor function after a stroke are poorly understood. We need the development of the technique of rehabilitation to the hemiplegic arm in stroke patients. Change of amplitude of motor evoked potential(MEP) is thought to be one of the factors which may contribute to recovery. We have investigated the change of MEPs in stroke patients during conventional and intensive training. The subjects were 27 patients with hemiplegia due to stroke (55.1±13.4 years old, 15.1±12.7 weeks after onset). They received intensive training of the himiplegic upper limbs for 2 to 6 weeks in addition to the basic conventional training for 2 weeks. After training, Uedas grade and Brunnstrom stage were improved. Focal transcranial magnetic stimulation(TMS) to the pollicis abductor brevis was followed up by evaluating amplitude of MEPs in 12 patients. The affected hemisphere was marked out over the central area in a 1cm or 2cm grid. TMS were given to 10 to 20 points using a figure-of-eight coil to elicit MEPs in contralateral abductor pollicis brevis muscle. The amplitudes of MEPs were measured peak-to-peak on each hemisphere at rest or under weak voluntary contraction. Based on the change of am plitude of MEP, 12 patients were devided into 3 groups, 1) decreased MEP amplitude group (1 case), 2) increased MEP amplitude group (4 cases), 3) no changed MEP amplitude group (7 cases). In decreased MEP group, the patient recoverd to the level of Brunnstrom stage V I.In increased MEP group, the patients recovered to the level of Brunnstrom stage I V or V.In no changed MEP group, the patients recovered to the level of Brunnstrom stage V or V I.Functional outcome of decreased and no changed MEP group was better than that of increased MEP group. These results suggests any relationship between the cortical excitability and the functional recovery after stroke.
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