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2003 Fiscal Year Final Research Report Summary

Study of Life Science as Complex Systems

Research Project

Project/Area Number 11CE2006
Research Category

Grant-in-Aid for COE Research

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo

Principal Investigator

KANEKO Kunihiko  The University of Tokyo, Graduate School of Arts and Science, Professor, 大学院・総合文化研究科, 教授 (30177513)

Co-Investigator(Kenkyū-buntansha) KAWATO Suguru  The University of Tokyo, Graduate School of Arts and Science, Professor, 大学院・総合文化研究科, 教授 (50169736)
SUGAWARA Tadashi  The University of Tokyo, Graduate School of Arts and Science, Professor, 大学院・総合文化研究科, 教授 (50124219)
ASASHIMA Makoto  The University of Tokyo, Graduate School of Arts and Science, Professor, 大学院・総合文化研究科, 教授 (00090564)
YOMO Tetsuya  Osaka University, Graduate School of Information Science and Technology, Associate Professor, 大学院・工学研究科, 助教授 (00222399)
YASUDA Kenji  The University of Tokyo, Graduate School of Arts and Science, Associate Professor, 大学院・総合文化研究科, 助教授 (20313158)
Project Period (FY) 1999 – 2003
KeywordsConstructive Biology / Self-replication system / cell differentiation / Activin / memory / micro-fabrication / sympatric speciation / symbiosis
Research Abstract

We have set up the basis of complex systems biology, to unveil universal features underlying all life systems, by taking a constructive approach, to set up a simple system both experimentally and theoretically.
(1)Synthesis of in-vitro artificial replication system consisting of DNA and DNA polymerase and others. Theoretical demonstration that molecules minority in number start to play the role of heredity, in the sense that they control the behavior of a cell relatively strongly and are preserved well. This theory is confirmed by the above experiment.
(2)Success of protein synthesis and RNA replication in liposome, observation and construction of stable self-replication of liposomes, and DNA hybridization on liposome.
(3)Theoretical discovery of universal statistical laws of chemical abundances in a cell that sustains recursive production, i.e., a power law in average gene expression and log-normal distribution of the abundances of each chemicals, as is confirmed experimentally.
(4)In-vit … More ro genesis of almost all organs from Xenopous undifferentiated cells, using activin and a few other proteins. Discovery of jump-over phenomena and community effect. Demonstration that the constructed eye and heart tissues work normally after transplantation to organisms.
(5)Theory of cell differentiation and developmental process based on a coupled dynamical systems, to show robustness and irreversibility.
(6)Construction of differentiation by E Coli by using embedded gene network.
(7)Evolution of E Coli to show that diversity is induced in a crowded condition.
(8)Proposition of a theory of symbiotic sympatric speciation.
(9)Construction of symbiotic system by E Coli and amoeba.
(10)Theoretical proposition that evolution speed is proportional to phenotypic fluctuation of clones, as confirmed by artificial selection experiment to increase fluorescence of protein in E Coli.
(11)Development of an equipment system that allows for long-term singe cell observation, manipulation, and on-chip cell sorter. Less

  • Research Products

    (206 results)

All Other

All Publications (206 results)

  • [Publications] K.Kaneko, T.Yomo: "Isologous Diversification for Robust Development of Cell Society"J.Theor.Biol.. 199. 243-256 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Fujimoto, K.Kaneko: "Noise Induced Boundary Dependence through Convective Instability"Physica D. 129. 203-222 (1999)

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  • [Publications] T.Yamamoto, K.Kaneko: "Tile Automaton : a model for an architecture of a living system"Artificial Life. 5. 37-76 (1999)

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  • [Publications] T.Shibata, T.Chawanya, K.Kaneko: "Noiseless Collective Motion out of Noisy Chaos"Phys.Rev.Lett.. 82. 4424-4427 (1999)

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  • [Publications] N.Kataoka, K.Kaneko: "Functional Dynamics I"Physica D. 138. 225-250 (2000)

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  • [Publications] N.Nakagawa, K.Kaneko: "Energy Absorption and Storage in a Hamiltonian System in Partial Contact with a Heat Bath"J.Phys.Soc.Japan. 69. 36-39 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] K.Kaneko, C.Furusawa: "Robust and irreversible development in cell soceity as a general consequence of intra-inter dynamics"Physica A. 280. 23-33 (2000)

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  • [Publications] C.Furusawa, K.Kaneko: "Origin of complexity in multicellular organisms"Phys.Rev.Lett.. 84. 6130-6133 (2000)

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  • [Publications] J Ito, K Kaneko: "Self-organized hierarchical structure in a plastic network of chaotic"Neural Networks. 13. 275-281 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] K.Kaneko, T.Yomo: "Sympatric Speciation : compliance with phenotype diversification from a single genotype"Proc.Roy.Soc.B. 267. 2367-2373 (2000)

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  • [Publications] N.Nakagawa, K.Kaneko, T.S.Komatsu: "Long-term Relaxation of a Composite System in Partial Contact with a Heat Bath"J.Phys.Soc.Jpn. 69. 3214-3222 (2000)

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  • [Publications] H.Takagi, K.Kaneko, T.Yomo: "Evolution of genetic code through isologous diversification of cellular states"Artificial Life. 6. 283-305 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] C.Furusawa, K.Kaneko: "Complex Orgnization in multicullarity as a necessity in evolution"Artificial Life, 6(2000). 6. 265-281 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] N.Kataoka, K.Kaneko: "Functional Dynamics II"Physica D. 149. 174-196 (2001)

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  • [Publications] K.Fujimoto, K.Kaneko: "Sensitive boundary condition dependence of noise-sustained"Phys.Rev.E., 63(2001). 63. 036218-036222 (2001)

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  • [Publications] Y.Togashi, K.Kaneko: "Transitions Induced by the Discreteness of Molecules in a Small Autocatalytic System"Phys.Rev.Lett., 86(2001). 86. 2459-2462 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] C.Furusawa, K.Kaneko: "Theory of Robustness of Irreversible Differentiation in a Stem Cell System : Chaos Hypothesis"J.Theor.Biol.. 209. 395-416 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] H.Takagi, K.Kaneko: "Differentiation and Replication of Spots in a Reaction Diffusion System with Many Chemicals"Europhys.Lett.. 56. 145-151 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] N.Nakagawa, K.Kaneko: "Relaxation, the Boltzmann-Jeans Conjecture and Chaos"Phys.Rev.E 64., (2001). 64. 055205(R)-209 (2001)

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  • [Publications] S.Sasa, T.S Komatsu: "Thermodynamic Irreversibility from high-dimensional"Hamiltonian Chaos, Prog.Theor.Phys.. 103. 1-52 (2000)

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  • [Publications] K.Hashimoto, T.Ikegami: "Heteroclinic Chaos, Chaotic Itinerancy and Neutral Attractors in Symmetrical Replicator Equations with Mutations"J.Phys.Soc.Japan.. 70. 349-352 (2001)

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  • [Publications] K.Harada, T.Ikegami: "Evolution of Specificity in an Immune Network"J.theor.biol.. 203. 439-449 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] N.Ono, T.Ikegami: "Artificial Chemistry : Computational Studies on the Emergence of Self-Reproducing Units"to be included in the proceedings of the European, Conference for Artificial Life. 186-195 (2001)

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  • [Publications] K.Yamada, T.Toyota, T.Sugawara, et al.: "Preparation of BODIPY probes for multicolor fluorescence imaging studies of membranedynamics"New J. Chem.. 25. 667-669 (2001)

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  • [Publications] H.Terao, T.Sugawara, Y.Kita, N.Sato, E.Kaho, S.Takeda: "Proton Relay in a One-Dimesional Hydrogen-Bonded Chain Composed of Water Molecules and a Squaric Acid Derivative."J.Am.Chem.Soc.. 123. 10468-10474 (2001)

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  • [Publications] Matsuura, M., Yamaguchi, M., Urabe, I., Yomo, T., et al.: "Importance of compartment formation for a self-encoding system."PNAS. 99(11). 7514-7517 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] YU, W., Sato, K., Urabe, I., Yomo, T., et al.: "Synthesis of functional Protein in liposome."J.Biosci.Bioeng. 92. 590-593 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] Kashiwagi, A., Noumachi, W., Urabe, I., Yomo, T., et al.: "Plasticity of fitness and diversification process during an experimental molecular evolution"J.Mol.Evol.. 52. 502-509 (2001)

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  • [Publications] Nakaishi, T., Ishizuka, Yomo, T., Urabe, I., et al.: "Purification and characterization of Qβ replicase with a His-tag."J.Mol.Catal.B : Enzymatic. 10. 351-356 (2001)

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  • [Publications] Okabayashi, K., Shoji, H., Asashima, M., et al.: "cDNA Cloning and Distribution of the Xenopus Follistatin-Related Protein Biochem"Biophys.Res.Commun.. 254. 42-48 (1999)

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  • [Publications] Chan, T., Ariizumi, T., Asashima, M.: "A Model system for Organ Engineering : Transplantation of in vitro Induced Pronephros"Natur wissenschaften. 86. 224-227 (1999)

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  • [Publications] Miyanaga, Y., Shiurba, R., Asashima, M.: "Blood cell induction in Xenopus animal cap explants : effects of fibroblast growth factor, bone morphogenetic proteins, and activin"Dev. Genes Evol.. 209. 69-76 (1999)

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  • [Publications] Asashima, M., Kinoshita, K., et al.: "Role of Activin and Other Peptide Growth Factors in Body patterning in the Early Amphibian Embryo"Int.Rev.Cytology. 191. 1-52 (1999)

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  • [Publications] Tamai, K., Yokota, C., Ariizumi, T., Asashima, M.: "Cytochalasin B inhibits morphogenetic movement and muscle differentiation of activin-treated ectoderm in Xenopus"Develop. Growth Differ.41,(1999). 41. 41-49 (1999)

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  • [Publications] Asashima, M., Yokota, C., et al.: "Peptide growth factors in amphibian embryogenesis : intersection of modern molecular approaches with traditional inductive interaction paradigms"Int.J.Dev.Biol.43,(1999). 43. 1-10 (1999)

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  • [Publications] Kuroda, H., Sakumoto, H., Kinoshita, K., Asashima, M.: "Changes in the adhesive properties of dissociated and reaggregated Xenopus laevis embryo cells"Develop. Growth Differ.. 41. 283-291 (1999)

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  • [Publications] Ariizumi, T., Komazaki, S., Asashima, M.: "Activin-treated Urodele Animal Caps : II. Interactions in Newt Animal Caps After Treatment with Activin A"Zoological Science. 16(1). 115-124 (1999)

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  • [Publications] Yamashita, M., Asashima, M., et al.: "Bio Experiment on Space Flyer Unit : Effects of Gravity on Early Development of Japanese Red Bellied Newt"J. Space Technology and Science. 13(2). 12-17 (1999)

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  • [Publications] Ninomiya, H., Asashima, M., et al.: "Endoderm differentiation and inductive effect of activin-treated ectoderm in Xenopus"Develop. Growth Differ.. 41. 391-400 (1999)

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      「研究成果報告書概要(和文)」より
  • [Publications] Fukui, A., Shiurba, R., Asashima, M.: "Activin Incorporation into Vitellogenic Oocytes of Xenopus Laevis"Cellular and Molecular Biology. 45(5). 545-554 (1999)

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  • [Publications] Hayata, T., Eisaki, A., Kuroda, H., Asashima, M.: "Expression of Brachyury-like T-box transcription factor, Xbra3 in Xeopus embryo"Dev. Genes Evol.. 209. 560-563 (1999)

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      「研究成果報告書概要(和文)」より
  • [Publications] Hayata, T., Kuroda, H., Eisaki, A., Asashima, M: "Expression of Xenopus T-box transcription factor, Tbx2 in Xenopus embryo"Dev. Genes Evol.. 209. 625-628 (1999)

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  • [Publications] Ariizumi, T., Takano, K., Asashima, M., Malacinski, G.M.: "Bioassays of Inductive Interactions in Amphibian Development"Methods in Molecular Biology 135: Dev. Biology Protocols. 1. 89-112 (1999)

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  • [Publications] Onuma, Y., Nishinakamura, R., Asashima, M., et al.: "Molecular Cloning of a Novel Xenopus spalt Gene (Xsal 3)"Biochemical and Biophysical Research Communications. 264. 151-156 (1999)

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  • [Publications] Shiurba, R., Hirabayashi, T., Asashima M, et al.: "Evidence that Far-Infrared Radiation Promotes Growth of Xenopus"Adv. Space Res.. 23(12). 2041-2044 (1999)

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  • [Publications] Ariizumim, T., Asashima, M.: "In vitro control of organogenesis and fundamental embryonic form by the peptide growth factor activin"J. Artif Organs. 2. 117-123 (1999)

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  • [Publications] Nishinakamura, R., Asashima, M., Yokota, T., et al.: "Activation of Stat3 by cytokine receptor gp 130 ventralizes Xenopus embryos independently of BMP-4"Dev.Biol.. 216. 481-490 (1999)

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  • [Publications] Asashima, M., Ariizumi, T., Malacinski, G.M., et al.: "Bioassays for Studying the Role of the Peptide Growth Factor Activin in Early Amphibian Embryogenesis"Methods in Molecular Biology 136: Developmental Biology Protocols. II. 15-26 (1999)

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  • [Publications] Furue, M., Okamoto, T., Asashima, M.: "Effect of TGF-β on morphogenesis in rat salivary gland-derived RSMG-1 Cells"Tiss.Cult.Res.Commun.. 18. 339-343 (1999)

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  • [Publications] Kuroda, H., Hayata, T., Eisake, A., Asashima M.: "Cloning a novel developmental regulating gene, Xotx5 : its potential role in anterior formation in Xenopus laevis"Develop. Growth Differ.. 42. 87-93 (2000)

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  • [Publications] Moriya, N., Komazaki, S., Asashima, M.: "In vitro organogenesis of pancreas in Xenopus laevis dorsal lips treated with retinoic acid"Develop. Growth Differ.. 42. 175-185 (2000)

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  • [Publications] Oka, T., Shiojima, I., Asashima, M., et al.: "FGF Plays a Critical Role in SM22α Expression during Xenopus Embryogenesis"Arteriosclerosis, Thrombosis, and Vascular biology. 907-914 (2000)

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  • [Publications] Sato, A., Asashima, M., Yokota, T., Nishinakamura, R.: "Gene expression pattern Cloing and expression pattern of a Xenopus pronephros-specific gene, XSMP-30"Mech.Dev.. 92. 273-275 (2000)

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  • [Publications] Asashima, M., Ariizumi, T., Malacinski, G.M.: "In vitro control of organogenesis and body patterning by activin during early amphibian development"Comparative Biochemistry and Physiology. 126. 169-178 (2000)

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  • [Publications] Malacinski, G.M., Ariizumi, T., Asashima, M: "The renaissance in amphibian embryology"Comparative Biochemistry and Physiology. 126. 179-187 (2000)

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  • [Publications] Chan, Te-Chuan, Asashima, M: "Development of the embryonic kidney"Clin.Exp.Nephrol. 4. 1-10 (2000)

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  • [Publications] Onuma, Y., Nishihara, R., Asashima, M., et al.: "Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis Development"Genes and Evolution. 210. 325-327 (2000)

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  • [Publications] Eisaki, A., Kuroda, H., Fukui, A., Asashima, M.: "XSIP1, a Member of Two-Handed Zinc Finger Proteins, Induced Anterior Neural Markers in Xenopus laevis Animal Cap"Biochemical and Biophysical Res. Com.. 271. 151-157 (2000)

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  • [Publications] Tanaka, K., Okabayashi, K., Asashima, M., et al.: ""The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family"Eur.J.Biochem.. 267. 1-13 (2000)

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  • [Publications] Fukui, A., Kishida, S., Kikuchi, A., Asashima, M.: "Effect of rat Axin domains on axis formation in Xenopus embryos"Develop. Growth & Differ.. 42(5). 489-498 (2000)

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      「研究成果報告書概要(和文)」より
  • [Publications] Moriya, N., Komazaki, S., Asashima, M., et al.: "In vitro pancreas formation from Xenopus ectoderm treated with activin and retinoic acid"Develop. Growth & Differ.. 42(6). 593-602 (2000)

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  • [Publications] Kadoya, T., Kishida, S., Asashima, M., et al.: "Inhibition of Wnt Signaling Pathway by A Novel Axin-binding Protein"J.Biol.Chem.. 275(47). 37030-37037 (2000)

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  • [Publications] Tanegashima, K., Yokota, C., Takahashi, S., Asashima, M: "Expression cloning of Xantivin, a Xenopus lefty/antivin related gene, involved in the regulation of activin signaling during mesoderm induction"Mech.Develop.. 99. 3-14 (2000)

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  • [Publications] M.Furue, T.Okamoto, S.Koshika, M.Asashima: "Isoleucine Prevents rat salivary gland epithelial cells from Apoptosis in Serum-Free Culture"In Vitro Cell.Dev.Biol.-Animal. 36. 287-289 (2000)

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  • [Publications] Sakamoto, I., Kishida, S., Asashima, M., et al.: "A Novel β-Catenin Binding Protein Inhibits β-Catenin-dependent Tcf Activation and Axis Formation"J.Biol.Chem.. 275(42). 32871-32878 (2000)

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  • [Publications] M.Nakaya, A.Fukui, M.Asashima, et al.: "Meiotic maturation induces animal-vegetal asymmetric distribution of a PKC and ASIP/PAR-3 in Xenopus oocytes"Development. 127. 5021-5031 (2000)

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  • [Publications] M.Asashima, T.Ariizumi, T.Hayata, A.Sato, A.Fukui: "Control of organogenesis and body plan formation during early amphibian development"Stem Cell and Cell Differentiation, Proceedings June. 22(24). 20-21 (2000)

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  • [Publications] S.Takahashi, C.Yokota, M.Asashima, et al.: "Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center"Development. 127. 5319-5329 (2000)

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  • [Publications] S.W.Cheong, A.Fukui, M.Asashima, C.J.Pfeiffer: "Spontaneous Thyroid-containing Teratoma Associated with Impaired Development in the African Clawed Frog, Xenopus laevis"J.Comp.Path.. 123. 110-118 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Fukui, S.Kishida, A.Kikuchi, M.Asashima: "Effects of rat Axin domains on axis formation in Xenopus embryos"Develop. Growth Differ.. 42. 489-498 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Te-chuan Chan, S.Takahashi, M.Asashima: "A Role for Xlim-1 in Pronephros Development in Xenopus laevis"Develop.Biol.. 228. 256-269 (2000)

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  • [Publications] S.Hino, S.Kishida, M.Asashima, et al.: "Inhibition of the Wnt Signaling Pathway by Idax, A Novel Dvl-binding Protein"Mol. Cell Biol.. 330-342 (2000)

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  • [Publications] J.Ichigi, M.Asashima: "Dome Formation and Tubule Morphogenesis by Xenopus Kidney A6 Cell Cultures Exposed to Microgravity Simulated with A 3D-Clinostat and to Hypergravity"In Vitro Cellular and Developmental Biology - Animal.. 37. 31-44 (2001)

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  • [Publications] M.Asashima, Tokindo S.Okada: "Spemann's influence on Japanese Developmental Biology"J.Dev.Biol.. 45. 57-65 (2001)

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  • [Publications] T.Ariizumi, M.Asashima: "In vitro induction systems for analyses of amphibian organogenesis and body patterning"J.Dev.Biol.. 45. 273-279 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Furue, Y.Zhang, M.Asashima, et al.: "Activin A induces Expression of Rat Sel-1/mRNA, a Negative Regulator of Notch Signaling, in Rat Salivary Gland-Derived Epithelial Cell."Biochemical and Biophysical Research Communications.. 282. 745-749 (2001)

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  • [Publications] I.Inoue, Y.Wakamoto, K.Yasuda, et al.: "On-ship Culture System for Observation of Isolated Individual Cells."Lab on a chip. 1. 5055 (2001)

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  • [Publications] Y.Wakamoto, I.Inoue, H.Moriguchi, K.Yasuda: "Analysis of single-cell differences using on-chip microsulture system and optical trapping."Fresenius'J.Anal.. (in press). (2001)

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  • [Publications] K.Kaneko: "From Coupled Dynamical Systems to Biological Irreversibility"Adv. in Chem. Phys.. 122. 53-73 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Akiyama, K.Kaneko: "Dynamical Systems Game Theory II"Phsyica D. 167. 36-71 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakaishi, T., Iio, K., Yomo, T., et al.: "Kinetic properties of Qβ replicase, and RNA dependent RNA polymeraseh"J.Biosci.Bioeng.. 93. 322-327 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Terada TP, Sasai M, Yomo T.: "Conformational change of the actomyosin complex drives the multiple stepping movement"Proc Natl Acad Sci U S A.. 99(14). 9202-9206 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kaneko, T.Yomo: "On a kinetic origin of heredity : minority control in replicating molecules"J.Theor.Biol.. 214. 563-576 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kaneko, T.Yomo: "Genetic Diversification through Interaction-driven Phenotype Differentiation"Evol Ecol. Res.. 4. 317-350 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Junji Ito, Kunihiko Kaneko: "Spontaneous structure formation in a network of chaotic units with variable connection strengths"Phys.Rev.Lett.. 88. 028701-1-028701-4 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Togashi, K.Kaneko: "Alteration of Chemical Concentrations by Discreteness Induced Transitions in Small Autocatalytic Systems"J.Phys.Soc.Japan. 72. 62-68 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] C.Furusawa, K.Kaneko: "Origin of Multicellular Organisms as an Inevitable Consequence of Dynamical Systems"Anatomical record. 268. 327-342 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kunihiko Kaneko: "Kinetic Origin of Heredity in a Replicating System with a Catalytic Network"J Biol. Phys.. 28. 781-792 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kunihiko Kaneko: "Symbiotic Sympatric Speciation : Compliance with Interaction-driven Phenotype Differentiation from a Single Genotype"Population Ecology. 44. 71-85 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kunihiko Kaneko: "Dominance of Minlnor attractors in Globally Coupled Dynamical Systems with more than 7 +- dehgrees of freedom"Phys.Rev.E.. 66. 055201(R) (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ishihara, K.Kaneko: "Simple dynamical system model of history dependent phenomena"J Phys Soc. Jpn. 71. 2357-2360 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Takagi, K.Kaneko: "Pattern dynamics of a multi-component reaction diffusion system : Differentiation of replicating spots"Int. J. Bifurcation and Chaos. 12・11. 2579-2598 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuroda, H., Inui, M., Sugimoto, K., Hataya, T., Asashima, M.: "Axial protocadherin is a mediator of prenotochord cell sorting in Xenopus"Developmental Biology. 244. 267-277 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onuma, Y., Takahashi, S., Asashima, M.et al.: "Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies"PNAS. 99(4). 2020-2025 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kadoya, T., Yamamoto, H., Asashima, M., et al.: "Desumoylation activity of Axam, a novel Axin-binding protein, is involved indownregulation of β-catenin"Molecular and Cellular Biology. 22(11). 3803-3819 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Emura, T., Asashima, M., et al.: "Experimental split cord malformations Pediatr."Neutrosurg.. 36. 229-235 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Osafune, K., Nishinakamura, R., Komazaki, S., Asashima, M.: "In vitro induction of the pronephric duct in Xenopus explants"Develop. Growth Differ.. 44. 161-167 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.Ito, K.Kaneko: "Spontaneous structure formation in a network of chaotic units with variable connection strengths"Phys.Rev.Lett.. 88. 028701-1 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kaneko: "Symbiotic Sympatric Speciation : Compliance with Interaction-driven Phenotype Differentiation from a Single Genotype"Population Ecology. 44. 71-85 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 金子邦彦 編集(著:金子邦彦, 四方哲也, 柏木明子, 古澤力 他): "複雑系のバイオフィジックス"共立出版株式会社. 214 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 金子 邦彦: "生命とは何か[複雑系生命論序説]"東京大学出版会. 430 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] G.Muller, S.A.Newman, Kaneko, K.et al.: "Origination of Organismal Form : Beyond the Gene in Developmental and Evolutionary Biology"MIT Press, London. 368 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Pikovsky, Y.Maistrenko, Kaneko, K., et al.: "Synchronization : Theory and Application"Kluwer Academic Publishers, London. 260 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kaneko, T.Yomo: "Isologous Diversification for Robust Development of Cell Society"J.Theor.Biol.. 199. 243-256 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Fujimoto, K.Kaneko: "Noise Induced Boundary Dependence through Convective Instability"Physica D. 129. 203-222 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamamoto, K.Kaneko: "Tile Automaton : a model for an architecture of a living system"Artificial Life. 5. 37-76 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Shibata, T.Chawanya, K.Kaneko: "Noiseless Collective Motion out of Noisy Chaos"Phys.Rev.Lett.. 82. 4424-4427 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kataoka, K.Kaneko: "Functional Dynamics I"Physica D. 138. 225-250 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nakagawa, K.Kaneko: "Energy Absorption and Storage in a Hamiltonian System in Partial Contact with a Heat Bath"J.Phys.Soc.Japan. 69. 36-39 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko, C.Furusawa: "Robust and irreversible development in cell soceity as a general consequence of intra-inter dynamics"Physica A. 280. 23-33 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C.Furusawa, K.Kaneko: "Origin of complexity in multicellular organisms"Phys.Rev.Lett.. 84. 6130-6133 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J Ito, K Kaneko: "Self-organized hierarchical structure in a plastic network of chaotic units"Neural Networks. 13. 275-281 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko, T.Yomo: "Sympatric Speciation : compliance with phenotype diversification from a single genotype"Proc.Roy.Soc.B. 267. 2367-2373 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nakagawa, K.Kaneko, T.S.Komatsu: "Long-term Relaxation of a Composite System in Partial Contact with a Heat Bath"J.Phys.Soc.Jpn. 69. 3214-3222 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Takagi, K.Kaneko, T.Yomo: "Evolution of genetic code through isologous diversification of cellular states"Artificial Life. 6. 283-30 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C.Furusawa, K.Kaneko: "Complex Orgnization in multicullarity as a necessity in evolution"Artificial Life. 6. 265-281 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kataoka, K.Kaneko: "Functional Dynamics II"Physica D. 149. 174-196 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Fujimoto, K.Kaneko: "Sensitive boundary condition dependence of noise-sustained structure"Phys.Rev.E.. 63. 036218-222 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Togashi, K.Kaneko: "Transitions Induced by the Discreteness of Molecules in a Small Autocatalytic System"Phys.Rev.Lett.. 86. 2459-2462 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C.Furusawa, K.Kaneko: "Theory of Robustness of Irreversible Differentiation in a Stem Cell System : Chaos Hypothesis"J.Theor.Biol.. 209. 395-416 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Takagi, K.Kaneko: "Differentiation and Replication of Spots in a Reaction Diffusion System with Many Chemicals"Europhys.Lett.. 56. 145-151 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nakagawa, K.Kaneko: "Relaxation, the Boltzmann-Jeans Conjecture and Chaos"Phys.Rev.E. 64. 055205(R)-209 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Sasa, T.S.Komatsu: "Thermodynamic Irreversibility from high-dimensional Hamiltonian Chaos"Prog.Theor.Phys.. 103. 1-52 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Hashimoto, T.Ikegami: "Heteroclinic Chaos, Chaotic Itinerancy and Neutral Attractors in Symmetrical Replicator Equations with Mutations"J.Phys.Soc.Japan. 70. 349-352 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Harada, T.Ikegami: "Evolution of Specificity in an Immune Network"J.theor.biol.. 203. 439-449 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Ono, T.Ikegami: "Artificial Chemistry : Computational Studies on the Emergence of Self-Reproducing Units, to be included in the proceedings of the European"Conference for Artificial Life. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Yamada, T.Toyota, T.Sugawara: "Preparation of BODIPY probes for multicolor fluorescence imaging studies of membranedynamics"New J.Chem.. 25. 667-669 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Terao, T.Sugawara, Y.Kita, N.Sato, E.Kaho, S.Takeda: "Proton Relay in a One-Dimensional Hydrogen-Bonded Chain Composed of Water Molecules and a Squaric Acid Derivative."J.Am.Chem.Soc.. 123. 10468-10474 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura, M., Yamaguchi, M., Urabe, I., Yomo, T.: "Importance of compartment formation for a self-encoding system."PNAS, USA. 99(11). 7514-7517 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] YU, W., Sato, K., Urabe, I., Yomo, T.: "Synthesis of functional Protein in liposome."J.Biosci.Bioeng.. 92. 590-593 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kashiwagi, A., Noumachi, W., Urabe, I., Yomo, T., et al.: "Plasticity of fitness and diversification process during an experimental molecular evolution"J.Mol.Evol.. 52. 502-509 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakaishi, T., Ishizuka, M., Yomo, T., Urabe, I., et al.: "Purification and characterization of Qβ replicase with a His-tag."J.Mol.Catal.B. 10. 351-356 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okabayashi, K., Shoji, H., Asashima, M., et al.: "cDNA Cloning and Distribution of the Xenopus Follistatin-Related Protein Biochem"Biophys.Res.Commun.. 254. 42-48 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chan, T., Ariizumi, T., Asashima, M.: "A Model system for Organ Engineering : Transplantation of in vitro Induced Pronephros"Natur wissenschaften. 86. 224-227 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyanaga, Y., Shiurba, R., Asashima, M.: "Blood cell induction in Xenopus animal cap explants : effects of fibroblast growth factor, bone morphogenetic proteins, and activin"Dev.Genes Evol.. 209. 69-76 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asashima, M., Kinoshita, K.: "Role of Activin and Other Peptide Growth Factors in Body Patterning in the Early Amphibian Embryo"Int.Rev.Cytology. 191. 1-52 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, K., Yokota, C., Ariizumi, T., Asashima, M.: "Cytochalasin B inhibits morphogenetic movement and muscle differentiation of activin-treated ectoderm in Xenopus"Develop.Growth Differ.. 41. 41-49 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asashima, M., Yokota, C.: "Peptide growth factors in amphibian embryogenesis : intersection of modern molecular approaches with traditional inductive interaction paradigms"Int.J.Dev.Biol.. 43. 1-10 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroda, H., Sakumoto, H., Kinoshita, K., Asashima, M.: "Changes in the adhesive properties of dissociated and reaggregated Xenopus laevis embryo cells"Develop.Growth Differ.. 41. 283-291 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ariizumi, T., Komazaki, S., Asashima, M.: "Activin-treated Urodele Animal Caps : II. Inductive Interactions in Newt Animal Caps After Treatment with Activin A"Zoological Science. 16(1). 115-124 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamashita, M., Asashima, M., et al.: "Bio Experiment on Space Flyer Unit : Effects of Gravity on Early Development of Japanese Red Bellied Newt"J.Space Technology and Science. 13(2). 12-17 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ninomiya, H., Asashima, M., et al.: "Endoderm differentiation and inductive effect of activin-treated ectoderm in Xenopus"Develop.Growth Differ.. 41. 391-400 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukui, A., Shiurba, R., Asashima, M.: "Activin Incorporation into Vitellogenic Oocytes of Xenopus Laevis"Cellular and Molecular Biology. 45(5). 545-554 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayata, T., Eisaki, A., Kuroda, H., Asashima, M.: "Expression of Brachyury-like T-box transcription factor, Xbra3 in Xeopus embryo"Dev.Genes Evol.. 209. 560-563 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayata, T., Kuroda, H., Eisaki, A., Asashima, M.: "Expression of Xenopus T-box transcription factor, Tbx2 in Xenopus embryo"Dev.Genes Evol.. 209. 625-628 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ariizumi, T., Takano, K., Asashima, M., Malacinski, G.M.: "Bioassays of Inductive Interactions in Amphibian Development"Methods in Molecular Biology 135 : Developmental Biology Protocols 1. 89-112 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onuma, Y., Nishinakamura, R., Asashima, M.: "Molecular Cloning of a Novel Xenopus spalt Gene (Xsal 3)"Biochemical and Biophysical Research Communications. 264. 151-156 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shiurba, R., Hirabayashi, Asashima M., et al.: "Evidence that Far-Infrared Radiation Promotes Growth of Xenopus Laevis"Adv.Space Res.. 23(12). 2041-2044 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ariizumi, T., Asashima, M.: "In vitro control of organogenesis and fundamental embryonic form by the peptide growth factor activin"J.Artif Organs. 2. 117-123 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishinakamura, R.,, Asashima, M., Yokota, T.: "Activation of Stat3 by cytokine receptor gp 130 ventralizes Xenopus embryos independently of BMP-4"Dev.Biol.. 216. 481-490 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asashima, M., Ariizumi, T., Malacinski, G.M.: "Bioassays for Studying the Role of the Peptide Growth Factor Activin in Early Amphibian Embryogenesis"Methods in Molecular Biology 136 : Developmental Biology Protocols II. 15-26 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furue, M., Okamoto, T., Asashima, M.: "Effect of TGF-β on morphogenesis in rat salivary gland-derived RSMG-1 Cells"Tiss.Cult.Res.Commun.. 18. 339-343 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroda, H., Hayata, T., Eisake, A., Asashima M.: "Cloning a novel developmental regulating gene, Xotx5 : its potential role in anterior formation in Xenopus laevis"Develop.Growth Differ.. 42. 87-93 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriya, N., Komazaki, S., Asashima, M.: "In vitro organogenesis of pancreas in Xenopus laevis dorsal lips treated with retinoic acid"Develop.Growth Differ.. 42. 175-185 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oka, T., Shiojima, I., Asashima, M., et al.: "FGF Plays a Critical Role in SM22α Expression during Xenopus Embryogenesis"Arteriosclerosis, Thrombosis, and Vascular biology. 907-914 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato, A., Asashima, M., Yokota, T., Nishinakamura, R.: "Gene expression pattern Cloing and expression pattern of a Xenopus pronephros-specific gene, XSMP-30"Mech.Dev.. 92. 273-275 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asashima, M., Ariizumi, T., Malacinski, G.M.: "In vitro control of organogenesis and body patterning by activin during early amphibian development"Comparative Biochemistry and Physiology. 126. 169-178 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Malacinski, G.M., Ariizumi, T., Asashima, M.: "The renaissance in amphibian embryology"Comparative Biochemistry and Physiology. 126. 179-187 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chan, Te-Chuan, Asashima, M.: "Development of the embryonic kidney"Clin.Exp.Nephrol. 4. 1-10 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onuma, Y., Nishihara, R., Asashima, M., et al.: "Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis Development"Genes and Evolution. 210. 325-327 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eisaki, A., Kuroda, H., Fukui, A., Asashima, M.: "XSIP1, a Member of Two-Handed Zinc Finger Proteins, Induced Anterior Neural Markers in Xenopus laevis Animal Cap"Biochemical and Biophysical Res.Com.. 271. 151-157 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka, K., Okabayashi, K., Asashima, M.: "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family"Eur.J.Biochem.. 267. 1-13 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukui, A., Kishida, S., Kikuchi, A., Asashima, M.: "Effect of rat Axin domains on axis formation in Xenopus embryos"Develop.Growth & Differ.. 42(5). 489-498 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriya, N., Komazaki, S., Asashima, M., et al.: "In vitro pancreas formation from Xenopus ectoderm treated with activin and retinoic acid"Develop.Growth & Differ.. 42(6). 593-602 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kadoya, T., Kishida, S., Asashima, M., Kikuchi, A.: "Inhibition of Wnt Signaling Pathway by A Novel Axin-binding Protein"J.Biol.Chem.. 275(47). 37030-37037 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanegashima, K., Yokota, C., Takahashi, S., Asashima, M.: "Expression cloning of Xantivin, a Xenopus lefty/antivin related gene, involved in the regulation of activin signaling during mesoderm induction"Mech.Develop.. 99. 3-14 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Furue, T.Okamoto, S.Koshika, M.Asashima: "Isoleucine Prevents rat salivary gland epithelial cells from Apoptosis in Serum-Free Culture"In Vitro Cell.Dev.Biol.-Animal. 36. 287-289 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakamoto, I., Kishida, S., Asashima, et al.: "A Novel β -Catenin Binding Protein Inhibits β-Catenin-dependent Tcf Activation and Axis Formation"J.Biol.Chem.. 275(42). 32871-32878 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Nakaya, A.Fukui, M.Asashima: "Meiotic maturation induces animal-vegetal asymmetric distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes"Development. 127. 5021-5031 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Asashima, T.Ariizumi, T.Hayata, A.Sato, A.Fukui: "Control of organogenesis and body plan formation during early amphibian development"Stem Cell and Cell Differentiation, Proceedings June. 22(24). 20-21 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Takahashi, C.Yokota, M.Asashima, et al.: "Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center"Development. 127. 5319-5329 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.W.Cheong, A.Fukui, M.Asashima, C.J.Pfeiffer: "Spontaneous Thyroid-containing Teratoma Associated with Impaired Development in the African Clawed Frog, Xenopus laevis"J.Comp.Path.. 123. 110-118 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Fukui, S.Kishida, A.Kikuchi, M.Asashima: "Effects of rat Axin domains on axis formation in Xenopus embryos"Develop.Growth Differ.. 42. 489-498 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Te-chuan Chan, S.Takahashi, M.Asashima: "A Role for Xlim-1 in Pronephros Development in Xenopus laevis"Develop.Biol.. 228. 256-269 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Hino, S.Kishida, M.Asashima, et al.: "Inhibition of the Wnt Signaling Pathway by Idax, A Novel Dvl-binding Protein"Mol.Cell Biol.. 330-342 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Ichigi, M.Asashima: "Dome Formation and Tubule Morphogenesis by Xenopus Kidney A6 Cell Cultures Exposed to Microgravity Simulated with A 3D-Clinostat and to Hypergravity"In Vitro Cellular and Developmental Biology-Animal.. 37. 31-44 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Asashima, T.S.Okada: "Spemann's influence on Japanese Developmental Biology."J.Dev.Biol.. 45. 57-65 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Ariizumi, M.Asashima: "In vitro induction systems for analyses of amphibian organogenesis and body patternig."J.Dev.Biol.. 45. 273-279 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Furue, Y.Zhang, M.Asashima: "Activin A Induces Expression of Rat Sel-1/mRNA, a Negative Regulator of Notch Signaling, in Rat Salivary Gland-Derived Epithelial Cell."Biochemical and Biophysical Research Communications.. 282. 745-749 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, Y.Wakamoto, K.Yasuda: "On-chip Culture System for Observation of Isolated Individual Cells"Lab on a chip. 1. 5055 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Wakamoto, I.Inoue, H.Moriguchi, K.Yasuda: "Analysis of single-cell differences using on-chip microculture system and optical trapping"Fresenius'J.Anal.Chem.. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko: "From Coupled Dynamical Systems to Biological Irreversibility"Adv. in Chem.Phys. 122. 53-73 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Akiyama, K.Kaneko: "Dynamical Systems Game Theory II"Phsyica D. 167. 36-71 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakaishi, T., Iio, K., Yomo, T.: "Kinetic properties of Q β replicase, an RNA dependent RNA polymeraseh."J.Biosci.Bioeng.. 93. 322-327 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terada TP, Sasai M, Yomo T.: "Conformational change of the actomyosin complex drives the multiple stepping movement"Proc Natl Acad Sci USA. 9;99(14). 9202-9206 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yomo, K.Kaneko: "On a kinetic origin of heredity : minority control in replicating molecules"J.Theor.Biol.. 214. 563-576 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko, T.Yomo: "Genetic Diversification through Interaction-driven Phenotype Differentiation"Evol Eco.Res.. 4. 317-350 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Ito, K.Kaneko: "Spontaneous structure formation in a network of chaotic units with variable connection strengths"Phys.Rev.Lett.. 88. 028701-1-028701-4 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Togashi, K.Kaneko: "Alteration of Chemical Concentrations through Discreteness-Induced Transitions in Small Autocatalytic Systems"J.Phys.Soc.Japan. 72. 62-68 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C.Furusawa, K.Kaneko: "Origin of Multicellular Organisms as an Inevitable Consequence of Dynamical Systems"Anatomical Record. 268. 327-342 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko: "Kinetic Origin of Heredity in a Replicating System with a Catalytic Network"J Biol.Phys.. 28. 781-792 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko: "Symbiotic Sympatric Speciation : Compliance with Interaction-driven Phenotype Differentiation from a Single Genotype"Population Ecology. 44. 71-85 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko: "Dominance of Minlnor attractors in Globally Coupled Dynamical Systems with more than 7 + -2 degrees of freedom"Phys.Rev.E.. 66. 055201(R) (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Ishihara, K.Kaneko: "Simple dynamical system model of history dependent phenomena"J.Phys.Soc.Jpn.. 71,10. 2357-2360 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Takagi, K.Kaneko: "Pattern Dynamics of a Multi-component Reaction Diffusion System : Differentiation of Replicating Spots"Int.J.Bifurcation and Chaos. 11. 2579-2598 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroda, H., Inui, M., Sugimoto, K., Hataya, T., Asashima, M.: "Axial protocadherin is a mediator of prenotochord cell sorting in Xenopus"Developmental Biology. 244. 267-277 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onuma, Y., Takahashi, S., Asashima, M., et al.: "Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies"PNAS. 99(4). 2020-2025 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kadoya, T., Yamamoto, H., Asashima, M.et al.: "Desumoylation activity of Axam, a nobel Axin-binding protein, is involved in downregulation of β-catenin"Molecular and Cellular Biology. 22(11). 3802-3819 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Emura, T., Asashima, M, et al.: "Experimental split cord malformations Pediatr."Neutrosurg.. 36. 229-235 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Osafune, K., Nishinakamura, R., Komazaki, S., Asashima, M.: "In vitro induction of the pronephric duct in Xenopus explants"Develop.Growth Differ.. 44. 161-167 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Ito, K.Kaneko: "Spontaneous structure formation in a network of chaotic units with variable connection strengths"Phys.Rev.Lett.. 88. 028701-1 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko: "Symbiotic Sympatric Speciation : Compliance with Interaction-driven Phenotype Differentiation from a Single Genotype"Population Ecology. 44. 71-85 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko, T.Yomo, A.Kashiwagi, C.Furusawa, et al.: "Biophysics as Complex Systems"Kyoritsu Shuppan Co.,Ltd. 214 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kaneko: "What is Life?"University of Tokyo Press. 430 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] G.Muller, S.A.Newman, K.Kaneko: "Origination of Organismal Form : Beyond the Gene in Developmental and Evolutionary Biology"MIT Press, London. 368 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Pikovsky, Y.Maistrenko, Kaneko, K., et al.: "Synchronization : Theory and Application"Kluwer Academic Publishers, London. 260 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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