2001 Fiscal Year Annual Research Report

抗原非特異的分子による情報伝達制御

Research Project

Project/Area Number	12051102
Research Institution	Osaka University
Principal Investigator	平野俊夫大阪大学, 医学系研究科, 教授 (40136718)
Co-Investigator(Kenkyū-buntansha)	米原伸京都大学, ウイルス研究所, 教授 (00124503) 義江修近畿大学, 医学部, 教授 (10166910)
Keywords	サイトカイン / ケモカイン / 接着因子 / アポトーシス
Research Abstract	抗原受容体を介する第1シグナルにより抗原特異的に選択されたリンパ球クローンの運命、すなわち、細胞増殖、機能分化、死、は第1シグナルと、サイトカイン等の抗原非特異的分子の受容体を介する第2シグナルとのクロストークにより決定される。このような抗原非特異的シグナルに関与するサイトカイン、ケモカイン、補助受容体、接着分子、細胞死に関与する分子とその受容体の構造と機能や細胞内情報伝達機構を分子レベルで解明すると共に、生体内でのこれら分子の免疫応答や免疫臓器構築における役割とその異常によって生じる各種の自己免疫疾患の発症機構を明らかにすることを目的とする。この目的のために以下の3計画班をおく。計画研究ア:サイトカイン、接着分子の情報伝達制御計画研究イ:ケモカインの情報伝達制御計画研究ウ:アポトーシスの情報伝達制御本調整班の目的は上記3つの計画研究の研究者が密な連携をもって、相補的に、また相互活性化しながら、研究を推進するように、研究打ち合わせ会議の開催、研究資材の交換、共通な研究支援体制の確立など、時機をえた柔軟な活動を行うことである。このために、平成13年6月25日と平成14年2月19日に調整班会議を開催し、共同研究の可能性を検討するとともに、各研究計画に対する相互助言、討論会を行った。又、各計画研究がスムースに行われるように、全体に共通する研究方法の条件設定を行うとともに、これらに必要な試薬などの一括購入を行った。

Research Products

(15 results)

All Other

All Publications (15 results)

[Publications] Kamimura, D., Hirano, T., et al.: "Tyrosine 759 of the cytokine receptor gp13O is involved in Listeria monocytogenes susceptibility"Genes and Immunity. (in press).
[Publications] Yamashita, S., Hirano, T., et al.: "Stat3 controls cell movements during zebrafish gastrulation"Developmental Cell. 2. 363-375 (2002)
[Publications] Nishida, K., Hirano, T., et al.: "Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling"Blood. 99. 1866-18692 (2002)
[Publications] Yamasaki, S., Hirano, T., et al.: "Docking protein Gab2 is phophorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules"J. Biol. Chem.. 276. 45175-45183 (2001)
[Publications] Narimatsu, M., Hirano, T., et al.: "Tissue-specific autoregulation of the stat3 gene and its role in interleukin 6-induced survival signals in T cells"Mol. Cell. Biol.. 21. 6615-6625 (2001)
[Publications] Nakayama, T., Yoshie, O.: "Inducible expression of a CC chemokine liver and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3α/CCL20 by"International Immunology. 13. 95-1032 (2001)
[Publications] Yoshie, O., Nomiyama, H., et al.: "Chemokines in immunity"Advances in Immunology. 78. 57-110 (2001)
[Publications] Fujiie, S., Yoshie, O., et al.: "Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3α/CCL20 in mucosal"International Immunology. 13. 1255-1263 (2001)
[Publications] Nakayama, T., Yoshie, O., et al.: "Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5"Journal of Virology. 76. 3072-3077 (2002)
[Publications] Yoshie, O., Yamada, Y., et al.: "Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus 1-transformed T cells"Blood. 99. 1505-1511 (2002)
[Publications] Shimaoka, T., Yonehara, S.: "Lectin-like oxidized low density lipoprotein receptor-1(LOX-1) supports cell adhesion to fibronectin"FEBS Letters. 504. 65-68 (2001)
[Publications] Murakawa, M., Yonehara, S.: "Apoptosis-Inducing Protein, AlP, from parasite-infected fish induced apoptosis in mammalian cells by two differentmolecular mechanisms"Cell Death Differ. 8. 298-307 (2001)
[Publications] Lee, K.K., Yonehara, S.: "Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)"J. Biol. Chem.. (in press).
[Publications] Lee, K.K., Yonehara, S., et al.: "MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation"J. Biol. Chem.. 276. 192762-19285 (2001)
[Publications] Shimaoka, T., Yonehara, S., et al.: "LOX-1 supports adhesion of gram-positive and gram-negative bacteria"J. Immunol.. 166. 5108-5114 (2001)

2001 Fiscal Year Annual Research Report

抗原非特異的分子による情報伝達制御

Principal Investigator

平野 俊夫 大阪大学, 医学系研究科, 教授 (40136718)

Research Products

[Publications] Kamimura, D., Hirano, T., et al.: "Tyrosine 759 of the cytokine receptor gp13O is involved in Listeria monocytogenes susceptibility"Genes and Immunity. (in press).

[Publications] Yamashita, S., Hirano, T., et al.: "Stat3 controls cell movements during zebrafish gastrulation"Developmental Cell. 2. 363-375 (2002)

[Publications] Nishida, K., Hirano, T., et al.: "Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling"Blood. 99. 1866-18692 (2002)

[Publications] Yamasaki, S., Hirano, T., et al.: "Docking protein Gab2 is phophorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules"J. Biol. Chem.. 276. 45175-45183 (2001)

[Publications] Narimatsu, M., Hirano, T., et al.: "Tissue-specific autoregulation of the stat3 gene and its role in interleukin 6-induced survival signals in T cells"Mol. Cell. Biol.. 21. 6615-6625 (2001)

[Publications] Nakayama, T., Yoshie, O.: "Inducible expression of a CC chemokine liver and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3α/CCL20 by"International Immunology. 13. 95-1032 (2001)

[Publications] Yoshie, O., Nomiyama, H., et al.: "Chemokines in immunity"Advances in Immunology. 78. 57-110 (2001)

[Publications] Fujiie, S., Yoshie, O., et al.: "Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3α/CCL20 in mucosal"International Immunology. 13. 1255-1263 (2001)

[Publications] Nakayama, T., Yoshie, O., et al.: "Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5"Journal of Virology. 76. 3072-3077 (2002)

[Publications] Yoshie, O., Yamada, Y., et al.: "Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus 1-transformed T cells"Blood. 99. 1505-1511 (2002)

[Publications] Shimaoka, T., Yonehara, S.: "Lectin-like oxidized low density lipoprotein receptor-1(LOX-1) supports cell adhesion to fibronectin"FEBS Letters. 504. 65-68 (2001)

[Publications] Murakawa, M., Yonehara, S.: "Apoptosis-Inducing Protein, AlP, from parasite-infected fish induced apoptosis in mammalian cells by two differentmolecular mechanisms"Cell Death Differ. 8. 298-307 (2001)

[Publications] Lee, K.K., Yonehara, S.: "Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)"J. Biol. Chem.. (in press).

[Publications] Lee, K.K., Yonehara, S., et al.: "MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation"J. Biol. Chem.. 276. 192762-19285 (2001)

[Publications] Shimaoka, T., Yonehara, S., et al.: "LOX-1 supports adhesion of gram-positive and gram-negative bacteria"J. Immunol.. 166. 5108-5114 (2001)

平野俊夫大阪大学, 医学系研究科, 教授 (40136718)