2002 Fiscal Year Annual Research Report

抗原非特異的分子による情報伝達制御

Research Project

Project/Area Number	12051102
Research Institution	Osaka University
Principal Investigator	平野俊夫大阪大学, 生命機能研究科, 教授 (40136718)
Co-Investigator(Kenkyū-buntansha)	米原伸京都大学, ウイルス研究所, 教授 (00124503) 義江修近畿大学, 医学部, 教授 (10166910)
Keywords	サイトカイン / ケモカイン / 接着因子 / アポトーシス
Research Abstract	抗原受容体を介する第1シグナルにより抗原特異的に選択されたリンパ球クローンの運命、すなわち、細胞増殖、機能分化、死、は第1シグナルと、サイトカイン等の抗原非特異的分子の受容体を介する第2シグナルとのクロストークにより決定される。このような抗原非特異的シグナルに関与するサイトカイン、ケモカイン、補助受容体、接着分子、細胞死に関与する分子とその受容体の構造と機能や細胞内情報伝達機構を分子レベルで解明すると共に、生体内でのこれら分子の免疫応答や免疫臓器構築における役割とその異常によって生じる各種の自己免疫疾患の発症機構を明らかにすることを目的とする。この目的のために以下の3計画班をおく。計画研究ア:サイトカイン、接着分子の情報伝達制御計画研究イ:ケモカインの情報伝達制御計画研究ウ:アポトーシスの情報伝達制御本調整班の目的は上記3つの計画研究の研究者が密な連携をもって、相補的に、また相互活性化しながら、研究を推進するように、研究打ち合わせ会議の開催、研究資材の交換、共通な研究支援体制の確立など、時機をえた柔軟な活動を行うことである。このために、平成14年7月8日と平成15年2月21日に調整班会議を開催し、各研究計画に対する相互助言、討論会を行った。又、各計画研究がスムースに行われるように、全体に共通する研究方法の条件設定を行うとともに、これらに必要な試薬などの一括購入を行った。平成15年2月20日〜23日には、総括班主催で国際免疫シンポジウムを開催した。本シンポジウム開催のために、プログラムの立案などを含めて種々の協力を行った。

Research Products

(18 results)

All Other

All Publications (18 results)

[Publications] Atsumi, T., T.Hirano, et al.: "A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp13O causes autoimmune arthritis"J. Exp Med.. 196. 979-990 (2002)
[Publications] Itoh, S., T.Hirano, et al.: "Adapter molecule Gab1 is specifically expressed in marginal zone B cells and negatively regulates TI-2 responses"J. Immunol.. 168. 5110-5116 (2002)
[Publications] Kamimura, D., T.Hirano, et al.: "Tyrosine 759 of the cytokine receptor gp13O is involved in Listeria monocytogenes susceptibility"Genes and Immunity. 3. 136-143 (2002)
[Publications] Nishida, K., T.Hirano, et al.: "Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling"Blood. 99. 1866-1869 (2002)
[Publications] Ishihara, K., Hirano: "IL-6 in autoimmune disease and chronic inflammatory proliferative disease"Cytokine Growth Factor Rev. 13. 357-368 (2002)
[Publications] Hirano, T.: "Revival of the autoantibody model in rheumatoid arthritis"Nature Immunology. 3. 342-344 (2002)
[Publications] Ishihara, K., Hirano: "T. The molecular basis of the cell-specificity of cytokine action"Biochim Biophys Acta.. 1592. 281-296 (2002)
[Publications] Sekiya, T., O.Yoshie, et al.: "Increased levels of a TH2-type CC chemokine thymus and activation-regulated chemokine (TARC) in serum and induced sputum of asthmatics"Allergy. 57. 173-177 (2002)
[Publications] Ueno, T., O.Yoshie, et al.: "Role of CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus"Immunity. 16. 205-218 (2002)
[Publications] Nakayama, T., O.Yoshie, et al.: "Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5"J. Virol.. 76. 3072-3077 (2002)
[Publications] Yoshie, O., et al.: "Frequent expression of CCR4 in adult T-cell leukaemia and human T-cell leukaemia virus type 1-transformed T cells"Blood. 99. 1505-1511 (2002)
[Publications] Nishimura, M., O.Yoshie, et al.: "Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin^+/granzyme B^+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression"J. Immunol. 168. 6173-6180 (2002)
[Publications] Horikawa, T., O.Yoshie, et al.: "IFN-γ-induced expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in dermatitis"Int. Immunol.. 14. 767-773 (2002)
[Publications] Nanki, T., O.Yoshie, et al.: "Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis"Arthritis Rheum.. 46. 2878-2883 (2002)
[Publications] Nakayama, T., O.Yoshie, et al.: "Cutting edge : profile of chemokine receptor expression on human plasma cells account for their efficient recruitment to target tissues"J. Immunol.. 170. 1136-1140 (2003)
[Publications] Hieshima, K., O.Yoshie, et al.: "CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity"J. Immunol. 170. 1452-1461 (2003)
[Publications] Yonehara, S.: "Death receptor Fas and autoimmune disease : from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody"Cytokine Growth Factor Rev. 13. 393-402 (2002)
[Publications] Sakamaki, K., S.Yonehara, et al.: "Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart"Cell Death Differ. 9. 1196-1206 (2002)

2002 Fiscal Year Annual Research Report

抗原非特異的分子による情報伝達制御

Principal Investigator

平野 俊夫 大阪大学, 生命機能研究科, 教授 (40136718)

Research Products

[Publications] Atsumi, T., T.Hirano, et al.: "A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp13O causes autoimmune arthritis"J. Exp Med.. 196. 979-990 (2002)

[Publications] Itoh, S., T.Hirano, et al.: "Adapter molecule Gab1 is specifically expressed in marginal zone B cells and negatively regulates TI-2 responses"J. Immunol.. 168. 5110-5116 (2002)

[Publications] Kamimura, D., T.Hirano, et al.: "Tyrosine 759 of the cytokine receptor gp13O is involved in Listeria monocytogenes susceptibility"Genes and Immunity. 3. 136-143 (2002)

[Publications] Nishida, K., T.Hirano, et al.: "Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling"Blood. 99. 1866-1869 (2002)

[Publications] Ishihara, K., Hirano: "IL-6 in autoimmune disease and chronic inflammatory proliferative disease"Cytokine Growth Factor Rev. 13. 357-368 (2002)

[Publications] Hirano, T.: "Revival of the autoantibody model in rheumatoid arthritis"Nature Immunology. 3. 342-344 (2002)

[Publications] Ishihara, K., Hirano: "T. The molecular basis of the cell-specificity of cytokine action"Biochim Biophys Acta.. 1592. 281-296 (2002)

[Publications] Sekiya, T., O.Yoshie, et al.: "Increased levels of a TH2-type CC chemokine thymus and activation-regulated chemokine (TARC) in serum and induced sputum of asthmatics"Allergy. 57. 173-177 (2002)

[Publications] Ueno, T., O.Yoshie, et al.: "Role of CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus"Immunity. 16. 205-218 (2002)

[Publications] Nakayama, T., O.Yoshie, et al.: "Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5"J. Virol.. 76. 3072-3077 (2002)

[Publications] Yoshie, O., et al.: "Frequent expression of CCR4 in adult T-cell leukaemia and human T-cell leukaemia virus type 1-transformed T cells"Blood. 99. 1505-1511 (2002)

[Publications] Nishimura, M., O.Yoshie, et al.: "Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin^+/granzyme B^+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression"J. Immunol. 168. 6173-6180 (2002)

[Publications] Horikawa, T., O.Yoshie, et al.: "IFN-γ-induced expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in dermatitis"Int. Immunol.. 14. 767-773 (2002)

[Publications] Nanki, T., O.Yoshie, et al.: "Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis"Arthritis Rheum.. 46. 2878-2883 (2002)

[Publications] Nakayama, T., O.Yoshie, et al.: "Cutting edge : profile of chemokine receptor expression on human plasma cells account for their efficient recruitment to target tissues"J. Immunol.. 170. 1136-1140 (2003)

[Publications] Hieshima, K., O.Yoshie, et al.: "CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity"J. Immunol. 170. 1452-1461 (2003)

[Publications] Yonehara, S.: "Death receptor Fas and autoimmune disease : from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody"Cytokine Growth Factor Rev. 13. 393-402 (2002)

[Publications] Sakamaki, K., S.Yonehara, et al.: "Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart"Cell Death Differ. 9. 1196-1206 (2002)

平野俊夫大阪大学, 生命機能研究科, 教授 (40136718)