2001 Fiscal Year Annual Research Report

細胞周期制御

Research Project

Project/Area Number	12060101
Research Institution	The University of Tokyo
Principal Investigator	岡山博人東京大学, 大学院・医学系研究科, 教授 (40111950)
Co-Investigator(Kenkyū-buntansha)	鍔田武志東京医科歯科大学, 難治疾患研究所, 教授 (80197756) 東江昭夫東京大学, 大学院・理学系研究科, 教授 (90029249) 岸本健雄東京工業大学, 大学院・生命理工学研究科, 教授 (00124222) 大矢禎一東京大学, 大学院・新領域創成科学研究科, 教授 (20183767) 西田育巧名古屋大学, 大学院・理学研究科, 教授 (50107059)
Keywords	細胞周期制御 / G1 / G2 / 分化 / アポト-シス / 癌
Research Abstract	特定領域研究「細胞周期制御」は、平成12年度に発足した。計画研究開始にあたる今年度は、必要な設備・機器の購入を中心に各班の研究支援に当たった。一方、当特定領域研究主催の第1回国際ワークショップを、平成14年1月28-29日に東京大学本郷キャンパス山上会館で開催した。ワークショップのテーマは「G1コントロール」で、細胞の増殖開始制御、分化制御、アポトーシス制御の観点から、この領域の第一線で活躍中の欧州から5名の研究者と国内から7名の研究者を招聘し、講演が行われた。海外の講演者の内訳は、英国から2名、フランスから1名、イタリアから1名、オーストリアから1名であった。延べ150名の参加者があり、活発な討論が行われ、研究の進行状態と残された問題が浮き彫りにされた。特に、複製開始点の活性化機構と足場非依存性細胞周期開始機構に関して日本から注目すべき発表があり、欧州の研究者からはアポトーシスの機構に関する発表が注目された。これに引き続いて29日、30日と2日かけて、当研究班の進捗状況の報告会を東京大学医学部一号館で開催した。70名近い班員が発表し、いずれも興味を引く研究ぞろいで、各班員にとってこれからの研究の参考になる有用なヒントが得られたとの意見であった。

Research Products

(29 results)

All Other

All Publications (29 results)

[Publications] Jinno, S. et al.: "Oncogenic cell cycle start control"Mut. Res.. 477. 23-29 (2001)
[Publications] Lin, J.et al.: "Cyclin D3-Cdk6 complex evades inhibition by inhibitor proteins and uniquely controls cell's growth competence"Oncogene. 20. 2000-2009 (2001)
[Publications] Tanaka, K. et al.: "Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism"EMBO J.. 20. 5779-5790 (2001)
[Publications] Tsukahara, K. et al.: "Anticancer agent e7O7O inhibits amino acid and uracil transport in fission yeast"Mol. Pharmacol. 60. 1254-1259 (2001)
[Publications] Isobe, H. et al.: "Synthesis and transfection capability of multi-functionalized fullerene polyamine"Chem. Lett.. 12. 1214-1215 (2001)
[Publications] Jinno, S. et al.: "Cdc6 requires anchorage for its expression"Oncogene. (in press).
[Publications] Gotoh, T. et al.: "Inactivation of the checkpoint kinase Cds 1 is dependent on cyclin B-Cdc2 kinases activation at the meiotic・・・"J. Cell Sci. 114. 3397-3406 (2001)
[Publications] Okumura, E. et al.: "Akt inhibits Myt1 in the signal ling pathway that leads to meiotic G2/M-phase transition"Nature Cell Biol.. 4. 111-116 (2002)
[Publications] Iwabuchi, M. et al.: "Coordinated regulation of M phase exit and S phase entry by the Cdc2 activity level in the early embryonic cell cycle"Dev. Biol.. (in press).
[Publications] Iwase, M., Toh-e, A.: "Nis1 encoded by YNLO78W : a new neck protein of Saccharomyces cerevisiae"Genes Genet Syst. 76. 335-343 (2001)
[Publications] Uesono, Y.Toh-e, A.: "Transient inhibition of translation initiation by osmotic stress"J Biol. Chem.. (in press).
[Publications] Takahashi, Y. et al.: "A novel factor required for the SUMO1/Smt3conjugation of yeast septins"Gene. 275. 223-231 (2001)
[Publications] Takahashi, Y. et al.: "Veast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme・・・"J Biol Chem.. 276. 48973-48977 (2001)
[Publications] Yoshida, S., Toh-e, A.: "Regulation of the localization of Dbf2 and Mob1 during cell division fo Saccharomyces cerevisiae"Genes Genet Syst. 76. 141-147 (2001)
[Publications] Takeuchi, J., Toh-e, A.: "Genetic dissection of th yeast 26S proteasome : cell cycle defects caused by the Deltarpn9 mutation"Biochimie. 83. 333-340 (2001)
[Publications] Asakawa, K. et al.: "A novel functional domain of Cdc15 kinase is required for its interaction with Tem1 GTPase in Saccharomyces cerevisiae"Genetics. 157. 1437-1450 (2001)
[Publications] Tsubata, T. et al.: "Regulation of B cell antigen receptor signaling by CD72"Sprnger-Verlag. 123-128 (2001)
[Publications] Suzuki, A, etal.: "Tcell-specific loss of Pten leads to defects in central and peripheral tolerance"Immunity. 14. 523-534 (2001)
[Publications] Adachi, T. et al.: "SHP-1 requires inhibitory co-receptors to downmodulate B cell antigen receptor-mediated phossphorylation of cellular ・・・"J Biol. Chem.. 276. 26648-26655 (2001)
[Publications] Tsubata, T.: "Molecular mechanisms for apoptosis induced by signaling through the B cell antigen recptor"Int. Rev. Immunol. 20. 791-803 (2001)
[Publications] Higuchi, T. et al.: "Cutting Edge : Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmunedisease"J. Immunol. 168. 9-12 (2002)
[Publications] kwon, Y.-J.et al.: "E2F-dependent transcription of the raf proto-oncogene during Drosophila development"Nucleic Acid. Res.. 29. 1808-1814 (2001)
[Publications] lnoue, H. et al.: "A Drosopila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK"EMBO. J.. 19. 5421-5430 (2001)
[Publications] Mizuno, T. et al.: "Drosophila myosin phosphatase and its role in dorsal closure"Development. (in press).
[Publications] Wada, S. et al.: "DNA polymerasee is required for coordinated and efficient chromosomal DNA replication in Xenpous egg extracts"Proc. Natl. Acad. Sci. USA. 98. 4978-4983 (2001)
[Publications] Gotoh, T. et al.: "Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B-Cdc2 kinase activation at the meiotic G2/M/phase"J. Cell Sci.. 114. 3397-3406 (2001)
[Publications] yasui, Y. et al.: "Protein kinases required for segregation of vimentin filaments in mitotic process"Oncogene. 20. 2868-2876 (2001)
[Publications] Inada, H. et al.: "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD"M. J. Cell Biol.. 155. 415-425 (2001)
[Publications] Goto, H. et al.: "Aurora-B phosphorylates histone H3 at serine 28 with regard to the mitosic chromosome condensation"Genes Cells. 7. 11-17 (2002)

2001 Fiscal Year Annual Research Report

細胞周期制御

Principal Investigator

岡山 博人 東京大学, 大学院・医学系研究科, 教授 (40111950)

Research Products

[Publications] Jinno, S. et al.: "Oncogenic cell cycle start control"Mut. Res.. 477. 23-29 (2001)

[Publications] Lin, J.et al.: "Cyclin D3-Cdk6 complex evades inhibition by inhibitor proteins and uniquely controls cell's growth competence"Oncogene. 20. 2000-2009 (2001)

[Publications] Tanaka, K. et al.: "Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism"EMBO J.. 20. 5779-5790 (2001)

[Publications] Tsukahara, K. et al.: "Anticancer agent e7O7O inhibits amino acid and uracil transport in fission yeast"Mol. Pharmacol. 60. 1254-1259 (2001)

[Publications] Isobe, H. et al.: "Synthesis and transfection capability of multi-functionalized fullerene polyamine"Chem. Lett.. 12. 1214-1215 (2001)

[Publications] Jinno, S. et al.: "Cdc6 requires anchorage for its expression"Oncogene. (in press).

[Publications] Gotoh, T. et al.: "Inactivation of the checkpoint kinase Cds 1 is dependent on cyclin B-Cdc2 kinases activation at the meiotic・・・"J. Cell Sci. 114. 3397-3406 (2001)

[Publications] Okumura, E. et al.: "Akt inhibits Myt1 in the signal ling pathway that leads to meiotic G2/M-phase transition"Nature Cell Biol.. 4. 111-116 (2002)

[Publications] Iwabuchi, M. et al.: "Coordinated regulation of M phase exit and S phase entry by the Cdc2 activity level in the early embryonic cell cycle"Dev. Biol.. (in press).

[Publications] Iwase, M., Toh-e, A.: "Nis1 encoded by YNLO78W : a new neck protein of Saccharomyces cerevisiae"Genes Genet Syst. 76. 335-343 (2001)

[Publications] Uesono, Y.Toh-e, A.: "Transient inhibition of translation initiation by osmotic stress"J Biol. Chem.. (in press).

[Publications] Takahashi, Y. et al.: "A novel factor required for the SUMO1/Smt3conjugation of yeast septins"Gene. 275. 223-231 (2001)

[Publications] Takahashi, Y. et al.: "Veast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme・・・"J Biol Chem.. 276. 48973-48977 (2001)

[Publications] Yoshida, S., Toh-e, A.: "Regulation of the localization of Dbf2 and Mob1 during cell division fo Saccharomyces cerevisiae"Genes Genet Syst. 76. 141-147 (2001)

[Publications] Takeuchi, J., Toh-e, A.: "Genetic dissection of th yeast 26S proteasome : cell cycle defects caused by the Deltarpn9 mutation"Biochimie. 83. 333-340 (2001)

[Publications] Asakawa, K. et al.: "A novel functional domain of Cdc15 kinase is required for its interaction with Tem1 GTPase in Saccharomyces cerevisiae"Genetics. 157. 1437-1450 (2001)

[Publications] Tsubata, T. et al.: "Regulation of B cell antigen receptor signaling by CD72"Sprnger-Verlag. 123-128 (2001)

[Publications] Suzuki, A, etal.: "Tcell-specific loss of Pten leads to defects in central and peripheral tolerance"Immunity. 14. 523-534 (2001)

[Publications] Adachi, T. et al.: "SHP-1 requires inhibitory co-receptors to downmodulate B cell antigen receptor-mediated phossphorylation of cellular ・・・"J Biol. Chem.. 276. 26648-26655 (2001)

[Publications] Tsubata, T.: "Molecular mechanisms for apoptosis induced by signaling through the B cell antigen recptor"Int. Rev. Immunol. 20. 791-803 (2001)

[Publications] Higuchi, T. et al.: "Cutting Edge : Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmunedisease"J. Immunol. 168. 9-12 (2002)

[Publications] kwon, Y.-J.et al.: "E2F-dependent transcription of the raf proto-oncogene during Drosophila development"Nucleic Acid. Res.. 29. 1808-1814 (2001)

[Publications] lnoue, H. et al.: "A Drosopila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK"EMBO. J.. 19. 5421-5430 (2001)

[Publications] Mizuno, T. et al.: "Drosophila myosin phosphatase and its role in dorsal closure"Development. (in press).

[Publications] Wada, S. et al.: "DNA polymerasee is required for coordinated and efficient chromosomal DNA replication in Xenpous egg extracts"Proc. Natl. Acad. Sci. USA. 98. 4978-4983 (2001)

[Publications] Gotoh, T. et al.: "Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B-Cdc2 kinase activation at the meiotic G2/M/phase"J. Cell Sci.. 114. 3397-3406 (2001)

[Publications] yasui, Y. et al.: "Protein kinases required for segregation of vimentin filaments in mitotic process"Oncogene. 20. 2868-2876 (2001)

[Publications] Inada, H. et al.: "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD"M. J. Cell Biol.. 155. 415-425 (2001)

[Publications] Goto, H. et al.: "Aurora-B phosphorylates histone H3 at serine 28 with regard to the mitosic chromosome condensation"Genes Cells. 7. 11-17 (2002)

岡山博人東京大学, 大学院・医学系研究科, 教授 (40111950)