2002 Fiscal Year Annual Research Report

大脳辺縁系における情動・記憶・免疫系の相互干渉機構の解明

Research Project

Project/Area Number	12210009
Research Institution	Toyama Medical and Pharmaceutical University
Principal Investigator	小野武年富山医科薬科大学, 医学部, 教授 (50019577)
Co-Investigator(Kenkyū-buntansha)	倉知正佳富山医科薬科大学, 医学部, 教授 (80019603) 村口篤富山医科薬科大学, 医学部, 教授 (20174287) 西条寿夫富山医科薬科大学, 医学部, 教授 (00189284) 大谷修富山医科薬科大学, 医学部, 教授 (90127548) 許南浩岡山大学, 大学院・医歯学総合研究科, 教授 (70173573)
Keywords	情動 / 記憶 / 認知 / 免疫 / 大脳辺縁系 / ニューロン活動 / サイトカイン / 行動
Research Abstract	I.神経生理学的研究:ドパミンD1またはD2受容体ノックアウト(D1-KO, D2-KO)マウスの場所学習行動および場所学習課題における側坐核ニューロンの応答性を解析した。その結果、1)課題学習は、D1-KOマウスで強度に、D2-KOマウスで軽度に障害される、2)D2-KOマウスでは側坐核における抑制型の報酬予期ニューロンが消失し、場所応答ニューロンが増加するなどの知見が得られた。 II.神経行動学的研究:ラットにNMDA受容体遮断薬を慢性投与して統合失調症モデル動物を作製し、社会行動とアルギニンバソプレッシン(AVP)神経系の変化を検討した。NMDA受容体遮断薬投与群では社会行動が減少し、外側中隔や分界条床核におけるV1a受容体結合密度が減少したことから統合失調症における社会性の障害にAVP神経系の異常が関与している可能性が示された。 III.神経解剖学的研究:ラット扁桃体基底外側核におけるドパミン神経系とGABA作動性ニューロン間のシナプス結合を共焦点レーザ顕微鏡と二重標識免疫電顕法で調べた。その結果、GABA作動性ニューロンがD2Rを発現し、GABA作動性ニューロン終末の約半数がGABA作動性ニューロンに対称性のシナプスを形成していることが明らかになった。以上より、ドパミン系は基底外側核のニューロンに直接的に、あるいはGABA作動性ニューロンを介して間接的に影響を及ぼしていることが示唆された。 VI.分子生物学的研究:1)ヒトCalminに対するモノクローナル抗体を作成し、各組織での発現を検討した。2)遺伝子発現ベクター[弱毒βH1(HSV)ウイルス]ならびにウイルス抑制剤を用いて、中枢神経系(大脳)に外来遺伝子を長期的に導入可能であることを検証した。 V.神経免疫学的研究:マウスにカイニン酸を腹腔内投与すると、小脳特異的に活性型IL-18および活性型IL-1が誘導され、1)活性型IL-18/IL-1を誘導する酵素カスパーゼ1の欠損マウスでは、カイニン酸投与による痙攣発症が発症せず、2)IL-18遺伝子欠損マウスでは、カイニン酸投与による痙攣からの回復が遅延したことから、IL-1がカイニン酸による痙攣を誘導し、IL-18は痙攣からの回復過程に関与することが示唆された。

Research Products
(66 results)

All Other

All Publications (66 results)

[Publications] Li, R., Nishijo, H., Ono, T., Ohtani, Y., Ohtani, O.: "Synapses on GABAergic neurons in the basolateral nucleus of the rat amygdala: double-labeling immunoelectron microscopy"Synapse. 43. 42-50 (2002)
[Publications] Hori, E., Uwano, T., Tamura, R., Miyake, N., Nishijo, H., Ono, T.: "Effects of a novel arginine-vasopressin derivative, NC-1900, on the spatial memory impairment of rats with transient forebrain ischemia"Cognitive Brain Res.. 13. 1-15 (2002)
[Publications] Toyomitsu, Y., Nishijo, H., Uwano, T., Kuratsu, J., Ono, T.: "Neuronal responses of the rat amygdala during extinction and reassociation learning in the elementary and configural associative tasks"Eur. J. Neurosci.. 15. 753-768 (2002)
[Publications] Tran, A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., Ono, T.: "Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice"Proc. Natl. Acad. Sci. USA. 99. 8986-8991 (2002)
[Publications] Tabuchi, E., Yokawa, T., Mallick, H., Inubushi, T., Kondoh, T., Ono, T., Torii, K.: "Spatio-temporal dynamics of brain activated regions during behavior in rats"Brain Res.. 951. 270-279 (2002)
[Publications] Shibata, T., Nishijo, H., Tamura, R., Miyamoto, K., Eifuku, S., Endo, S., Ono, T.: "Generators of visual evoked potentials for faces and eyes in the human brain as determined by dipole localization"Brain Topography. 15. 51-63 (2002)
[Publications] Hori, E., Tabuchi, E., Matsumura, N., Tamura, R., Eifuku, S., Endo, S., Nishijo, H., Ono, T.: "Representation of place by monkey hippocampal neurons in real and virtual translocation"Hippocampus. (in press).
[Publications] Kobayashi, T., Tran, A.H., Nishijo, H., Ono, T., Matsumoto, G.: "Contribution of hippocampal place cell activity to learning and formation of goal-directed navigation in rats"Neuroscience. (in press).
[Publications] Nishimura, F.T., Fukunaga, T., Kajiura, H., Umeno, K., Takakura, H., Ono, T., Nishijo, H.: "Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young japanese subjects"Autonomic Neuroscience : Basic and Clinical. (in press).
[Publications] Nishimura, F.T., Fukunaga, T., Yokomukai, Y., kajiura, H., Ono, T., Nishijo, H.: "Age-dependent changes in electroencephalographic responses to alcohol consumption in subjects with aldehyde dehydrogenase-2 genetic variations"Alcoholism: Clin. and Exp. Res.. (in press).
[Publications] Takakura, H., Umeno, K., Tabuchi, E., Hori, E., Miyamoto, K., Aso, S., Watanabe, Y., Ono, T., Nishijo, H.: "SDifferential activation in the medial temporal lobe during a sound-sequence discrimination task across age in human subjects"Neuroscience. (in press).
[Publications] Umeno, K., Hori, E., Tabuchi, E., Takakura, H., Miyamoto, K., Ono, T., Nishijo, H.: "Gamma-band EEGs predict autonomic responses during mental arithmetic"NeuroReport. (in press).
[Publications] 旭雄士, 林央周, 田村了以, 永福智志, 西条寿夫, 小野武年, 遠藤俊郎: "サル脳内ニューロン活動記録実験におけるMRI透瞭画像作製と軸補正の有用性-画像誘導手術支援システムの応用-"機能的脳神経外科. 41. 84-85 (2002)
[Publications] 数井健一, 佐々木和男, 堀悦郎, 田渕英一, 梅野克身, 小野武年, 西条寿夫: "仮想現実空間探索課題におけるサル海馬体ニューロンの応答性"信学技報(電子情報通信学会技術研究報告). MBE. 3-5 (2002)
[Publications] Takahashi, T., kawasaki, Y., Kurokawa, K., Hagino, H., Nohara, S., Yamashita, I., Nakamura, K., Murata, M., Matsui, M., Suzuki, M., Seto, H., Kurachi, M.: "Lack of normal structural asymmetry of the anterior singulate gyrus in female patients with schizophrenia : a volumetric magnetic resonance imaging study"Schizophr. Res.. 55. 69-81 (2002)
[Publications] Suzuki, M., Nohara, S., Hagino, H., Kurakawa, K., Yotsutsuji, T., Kawasaki, Y., Takahashi, T., matsui, M., Watanabe, N., Seto, H., Kurachi, M.: "Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI"Schizophr. Res.. 55. 41-54 (2002)
[Publications] Murata, M., Suzuki, M., Tanaka, K., Tajiri, K., Emori, K., Kurachi, M.: "N-methyl-D-aspartate-R1 receptor antisense oligodeoxynucleotide modulates pre-and postsynaptic expression of D2 dopamine receptors in the rat"Neurosci. Lett.. 335. 9-12 (2002)
[Publications] Matsui, M., Sumiyoshi, T., Niu, L., Kurokawa, K., Kurachi, M.: "MMPI profile characteristics of schizotypal personality disorder"Psychiatry Clin. Neurosci.. 56. 443-452 (2002)
[Publications] Matsui, M., Yoneyama, E., Sumiyoshi, T., Noguchi, K., Nohara, S., Suzuki, M., Kawasaki, Y., Seto, H., Kurachi, M.: "Lack of self-control as assessed by a personalitu inventory is related to reduced volume of supplementary motor area"Psychiatry Res. Neuroimaging. 116. 53-61 (2002)
[Publications] Hagino, H., Suzuki, M., Mori, K., Nohara, S., Yamashita, I., Takahashi, T., Kurokawa, K., Matsui, M., Watanabe, N., Seto, H., Kurachi, M.: "Proton magnetic resonance spectroscopy of the inferior frontal gyrus and thalamus, and its relationship to verbal learning task performance in male patients with schizophrenia : a preliminary report"Psychiatry Clin. Neurosci.. 56. 449-507 (2002)
[Publications] Kurachi, M.: "Pathogenesis of schizophrenia : PartI. Symptomatology, cognitive characteristics and brain morphology"Psychiatry Clin. Neurosci.. 57. 3-8 (2003)
[Publications] Kurachi, M.: "Pathogenesis of schizophrenia : PartII. Temporo-frontal two-step hypothesis"Psychiatry Clin. Neurosci.. 57. 9-16 (2003)
[Publications] Takahashi, T., Suzuki, M., Kawasaki, Y., Hagino, H., Yamashita, I., Nohara, S., Nakamura, K., Seto, H., Kurachi, M.: "Perigenual cingulated gyrus volume in patients with schizophrenia : a magnetic resonance imaging study"Biol. Psychiatry. (in press).
[Publications] Takahashi, T., Suzuki, M., Kawasaki, Y., Kurokawa, K., Hagino, H., Yamashita, I., Zhou, S-Y., Nohara, S., Nakamura, K., Seto, H., Kurachi, M.: "Volumetric magnetic resonance imaging study of the anterior cingulated gyrus in schizotypal disorder"Eur. Arch. Psychiatry Clin. Neurosci.. (in press).
[Publications] Tonoya, Y., Matsui, M., Kurachi, M., Kurokawa, K., Sumiyoshi, T.: "Exploratory eye movements in schizophrenia : effects of figure size and the instruction on visual search"Eur. Arch. Psychiatry Clin. Neurosci.. (in press).
[Publications] Yotsutsuji, T., Saito, O., Suzuki, M., Hagino, H., Mori, K., Takahashi, T., Kurokawa, K., Matsui, M., Seto, H., Kurachi, M.: "Quantification of lateral ventricular subdivisions in schizophrenia by high-resolution three-dimensional MR imaging"Psychiatry Res. Neuroimaging. (in press).
[Publications] Zhou, S-Y., Suzuki, M., Hagino, H., Takahashi, T., Kawasaki, Y., Nohara, S., Yamashita, I., Seto, H., Kurachi, M.: "Decreased Volume and Increased Asymmetry of the Anterior Limb of the Internal Capsule in Patients with Schizophrenia"Biol. Psychiatry. (in press).
[Publications] 山下委希子, 松井三枝, 倉知正佳, 野原茂, 高橋努, 米山英一, 加藤奏, 黒川賢造: "分裂病型障害患者と精神分裂病患者の神経心理学的プロフィールの比較"精神医学. 44. 845-851 (2002)
[Publications] Kurokawa, M., Tsurita, M., Brown, J., Fukuda, Y., Shiraki, K.: "Effect of interleukin-12 level augmented by Kakkon-to, an herbal medicine, on the early stage of influenza infection in mice"Antiviral Res.. 56. 183-188 (2002)
[Publications] Akanitapichat, P., Kurokawa, M., Tewtrakul, S., Pramyothin, P., Sripanidkulchai, B., Shiraki, K., Hattori, M.: "Inhibitory activities of Thai medicinal plants against herpes simplex type 1, poliovirus type 1, and measles virus"J. Traditional Med.. 19. 174-180 (2002)
[Publications] Takasaki, I., Sasaki, A., Andoh, T., Nojima, H., Shiraki, K., Kuraishi, Y.: "Effects of analgesics on delayed postherpetic pain in mice"Anesthesiology. 96. 1168-1174 (2002)
[Publications] Ohsaki, M., Kurokawa, M., Nawawi, A., Nakamura, N., Hattori, M., Shiraki, K.: "Characterization of anti-herpes simplex virus type 1 activity of an alkaloid FK 3000 from Stephania cepharantha"J. Traditional Med.. 19. 129-136 (2002)
[Publications] Furuta, Y., Takahashi, K., Fukuda, Y., Kuno, M., Kamiyama, T., Kozaki, K., Nomura, N., Egawa, H., Minami, S., Watanabe, Y., Narita, H., Shiraki, K.: "In vitro and in vivo activities of anti-influenza viral compound T-705"Antimicrob. Agents Chemother.. 46. 977-981 (2002)
[Publications] Phumiamorn, S., Sato, H., Kamiyama, T., Kurokawa, M., Shiraki, K.: "Induction of humoral and cell-mediated immunity to hepatitis B surface antigen by a novel adjuvant activity of Oka varicella vaccine"J. Gen. Virol.. 84. 287-291 (2003)
[Publications] Fukuda, Y., Yamamura, J., Uwano, T., Nishijo, H., Kurokawa, M., Fukuda, M., Ono, T., Shiraki, K.: "Regulated transgene delivery by ganciclovir in the brain without physiological alterations by a live attenuated herpes simplex virus vector"Neuroscience Res.. 45. 233-241 (2003)
[Publications] Kataoka, K., Huh, N.: "A novel b1, 3-N-acetylglucosaminyltransferase involved inÅ@invasion of cancer cells as assayed in vitro"Bichem. Biophys. Res. Commun.. 294(4). 843-848 (2002)
[Publications] Ogawa, H., Gomi, T., Takusagawa, F., Masuda, T., Goto, T., Huh, N.: "Evidence for a dimeric structure of rat liver serine dehydratase"Int. J. Biochem. Cell Biol.. 34(5). 533-543 (2002)
[Publications] Kondo, A., Sakaguchi, M., Makino, E., Namba, M., Okada, S., Huh, N.: "Localization of S100C immunoreactivity in various human tissues"Acta Med. Okayama. 56(1). 31-34 (2002)
[Publications] Huh, W.K., Oono, T., Shirafuji, Y., Akiyam, H., Arata, J., Sakaguchi, M., Huh, N., Iwatsuki, K.: "Dynamic alteration of human β-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin"J. Mol. Med.. 80(10). 678-684 (2002)
[Publications] Miyazaki, M., Akiyama, I., Sakaguchi, M., Nakashima, E., Okada, M., kataoka, K., Huh, N.: "Improved conditions to induce hepatocytes from rat bone marrow cells in culture"Biochem. Biophys. Res. Commun.. 298(1). 24-30 (2002)
[Publications] Shibakura, M., Niiya, K., Kiguchi, T., Kitajima, I., Niiya, M., Asami, N., Huh, N., Nakata, Y., Harada, M., Tanimoto, M.: "Induction of interleukin-8 and monocyte chemoattractant protein-1 by doxorubicin in human small-cell lung carcinoma cells"Int. J. Cancer. 103(3). 380-386 (2003)
[Publications] Nakajima, A., Kataoka, K., Hong, M., Sakaguchi, M., Huh, N.: "BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential"Cancer Lett.. (in press).
[Publications] Makino, T., Takaishi, M., Toyoda, T., Morohashi, M., Huh, N.: "Expression of Hornerin in Stratified Squamous Epithelium in the Mouse : A Comparative Analysis with Profilaggrin"J. Histochem. Cytochem.. (in press).
[Publications] Takaishi, M., Ishisaki, Z., Yoshida, T., Huh, N.: "Expression of calmin, a novel developmentally regulated brain protein with calponin-homology domains"Mol. Brain Res.. (in press).
[Publications] Kishi, H., Jin, Z-X., Wei, X-C., Nagata, T., Matsuda, T., Saito, S., Muraguchi, A.: "Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells"Blood. 99. 576-583 (2002)
[Publications] Nagata, T., Kishi, H., Liu, Q-L., Matsuda, T., Imanaka, T., Tsukada, K., Kang, D., muraguchi, A.: "The regulation of DNAse activities in subcellular compartments of activated thymocytes"Immunology. 105. 339-406 (2002)
[Publications] Wei, X-C., Kishi, H., Zhao, W-P., Kondo, S., Matsuda, T., Saito, S., Muraguchi, A.: "Characterization of chromatin structure and enhancerelements for murine recombination activating gene-2"J. Immunol.. 169. 873-881 (2002)
[Publications] Jin, Z-X., Kishi, H., Wei, X-C, Matsuda, T., Saito, S., Muraguchi, A.: "LEF-1 binds and activates the RAG-2 promoter together with c-Myb and Pax-5 in immature B cells"J. Immunol.. 169. 3783-3792 (2002)
[Publications] 川崎康弘, 鈴木道雄, 中村主計, 倉知正佳: "形態画像.特集「臨床検査による精神科診断はどこまで可能となったか」"精神科診断学. 13(2). 145-152 (2002)
[Publications] 許南浩: "ES細胞"岡山医学会雑誌. 114(1). 59-61 (2002)
[Publications] Nishijo, H., Hori, E., Tazumi, T., Eifuku, S., Umeno, K., Tabuchi, E., Ono, T.: "Role of the monkey amygdala in social cognition. In : Cognition and Emotion in the Brain"Elsevier (in press).
[Publications] Eifuku, S., De Souza, W.C., Tamura, R., Nishijo, H., Ono, T.: "On the organization of face memory. In : Cognition and Emotion in the Brain"Elsevier (in press).
[Publications] Tran, A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., Ono, T.: "Dopamine D2 receptor-knockout changed accumbens neural response to prediction of reward associated with place in mice. In : Cognition and Emotion in the Brain"Elsevier (in press).
[Publications] Komura, Y., Tamura, R., Uwano, T., Nishijo, H., Ono, T.: "Transmodal coding for reward prediction in the audiovisual thalamus. In : Cognition and Emotion in the Brain"Elsevier (in press).
[Publications] 西条寿夫, 小野武年: "情動のメカニズムと大脳辺縁系セラピストのための基礎研究論文集(4)「人間行動と皮質下機能」第3部大脳辺縁系と情動・動機づけ,永井洋一編"協同医書出版社. 233-266 (2002)
[Publications] 上野照子, 小野武年: "扁桃体と情動セラピストのための基礎研究論文集(4)「人間行動と皮質下機能」第3部大脳辺縁系と情動・動機づけ, 永井洋一編"協同医書出版社. 295-318 (2002)
[Publications] 小野武年, 西条寿夫: "大脳辺縁系・大脳基底核における情と意の出力機構-本能, 情動, 生きる喜び-「情と意の脳科学-人とは何か」,1.情と意の脳神経構築,松本元小野武年共編"培風館. 2-25 (2002)
[Publications] 西条寿夫, 小野武年: "情と意における大脳辺縁系と連合野の役割-生物学的価値評価,行動戦略の決定-「情と意の脳科学-人とは何か」,1.情と意の脳神経構築,松本元小野武年共編"培風館. 46-67 (2002)
[Publications] 西条寿夫, 小野武年: "摂食行動基礎栄養学第5版,吉田勉編著"医歯薬出版. 174-178 (2003)
[Publications] 小野武年, 上野照子: "情動脳神経科学"三輪書店 (印刷中).
[Publications] 田村了以, 小野武年: "快・不快の神経機構脳の科学"星和書店 (印刷中).
[Publications] Matsui, M., Yoneyama, E., Sumiyoshi, T., Noguchi, K., Nohara, S., Kurachi, M., Seto, H.: "Poor self-control in personality inventory and reduced volume of supplementary motor area. In Hirata, K.,Koga, Y.,Yamazaki, R.(eds.) Recent advances in human mapping : international congress series 1232"Elsevier. 131-135 (2002)
[Publications] Matsui, M., Yoneyama, E., Sumiyoshi, T., Noguchi, K., Nohara, S., Seto, H., Kurachi, M.: "Lack of self-control in personality inventory and reduced volume of supplementary motor area. In Ogura, C.,Recent advances in early intervention and prevention in psychiatric disorders"Seiwa-Shoten. 268-269 (2002)
[Publications] 倉知正佳, 川崎康弘: "統合失調症の病態形成と脳の発達新世紀の精神科治療第1巻統合失調症の診断学"中山書店. 30-39 (2002)
[Publications] 倉知正佳: "精神分裂病:自我と社会性の脳内機構. 「情と意の脳科学」,松本元,小野武年共編"培風館. 174-189 (2002)
[Publications] 許南浩: "バイオ人工皮膚. 現代化学増刊「再生医学・再生医療」,室田誠逸編"東京化学同人. 211-213 (2002)

2002 Fiscal Year Annual Research Report

大脳辺縁系における情動・記憶・免疫系の相互干渉機構の解明

Principal Investigator

小野 武年 富山医科薬科大学, 医学部, 教授 (50019577)

Research Products

[Publications] Li, R., Nishijo, H., Ono, T., Ohtani, Y., Ohtani, O.: "Synapses on GABAergic neurons in the basolateral nucleus of the rat amygdala: double-labeling immunoelectron microscopy"Synapse. 43. 42-50 (2002)

[Publications] Hori, E., Uwano, T., Tamura, R., Miyake, N., Nishijo, H., Ono, T.: "Effects of a novel arginine-vasopressin derivative, NC-1900, on the spatial memory impairment of rats with transient forebrain ischemia"Cognitive Brain Res.. 13. 1-15 (2002)

[Publications] Toyomitsu, Y., Nishijo, H., Uwano, T., Kuratsu, J., Ono, T.: "Neuronal responses of the rat amygdala during extinction and reassociation learning in the elementary and configural associative tasks"Eur. J. Neurosci.. 15. 753-768 (2002)

[Publications] Tran, A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., Ono, T.: "Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice"Proc. Natl. Acad. Sci. USA. 99. 8986-8991 (2002)

[Publications] Tabuchi, E., Yokawa, T., Mallick, H., Inubushi, T., Kondoh, T., Ono, T., Torii, K.: "Spatio-temporal dynamics of brain activated regions during behavior in rats"Brain Res.. 951. 270-279 (2002)

[Publications] Shibata, T., Nishijo, H., Tamura, R., Miyamoto, K., Eifuku, S., Endo, S., Ono, T.: "Generators of visual evoked potentials for faces and eyes in the human brain as determined by dipole localization"Brain Topography. 15. 51-63 (2002)

[Publications] Hori, E., Tabuchi, E., Matsumura, N., Tamura, R., Eifuku, S., Endo, S., Nishijo, H., Ono, T.: "Representation of place by monkey hippocampal neurons in real and virtual translocation"Hippocampus. (in press).

[Publications] Kobayashi, T., Tran, A.H., Nishijo, H., Ono, T., Matsumoto, G.: "Contribution of hippocampal place cell activity to learning and formation of goal-directed navigation in rats"Neuroscience. (in press).

[Publications] Nishimura, F.T., Fukunaga, T., Kajiura, H., Umeno, K., Takakura, H., Ono, T., Nishijo, H.: "Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young japanese subjects"Autonomic Neuroscience : Basic and Clinical. (in press).

[Publications] Nishimura, F.T., Fukunaga, T., Yokomukai, Y., kajiura, H., Ono, T., Nishijo, H.: "Age-dependent changes in electroencephalographic responses to alcohol consumption in subjects with aldehyde dehydrogenase-2 genetic variations"Alcoholism: Clin. and Exp. Res.. (in press).

[Publications] Takakura, H., Umeno, K., Tabuchi, E., Hori, E., Miyamoto, K., Aso, S., Watanabe, Y., Ono, T., Nishijo, H.: "SDifferential activation in the medial temporal lobe during a sound-sequence discrimination task across age in human subjects"Neuroscience. (in press).

[Publications] Umeno, K., Hori, E., Tabuchi, E., Takakura, H., Miyamoto, K., Ono, T., Nishijo, H.: "Gamma-band EEGs predict autonomic responses during mental arithmetic"NeuroReport. (in press).

[Publications] 数井健一, 佐々木和男, 堀 悦郎, 田渕英一, 梅野克身, 小野武年, 西条寿夫: "仮想現実空間探索課題におけるサル海馬体ニューロンの応答性"信学技報(電子情報通信学会技術研究報告). MBE. 3-5 (2002)

[Publications] Murata, M., Suzuki, M., Tanaka, K., Tajiri, K., Emori, K., Kurachi, M.: "N-methyl-D-aspartate-R1 receptor antisense oligodeoxynucleotide modulates pre-and postsynaptic expression of D2 dopamine receptors in the rat"Neurosci. Lett.. 335. 9-12 (2002)

[Publications] Matsui, M., Sumiyoshi, T., Niu, L., Kurokawa, K., Kurachi, M.: "MMPI profile characteristics of schizotypal personality disorder"Psychiatry Clin. Neurosci.. 56. 443-452 (2002)

[Publications] Matsui, M., Yoneyama, E., Sumiyoshi, T., Noguchi, K., Nohara, S., Suzuki, M., Kawasaki, Y., Seto, H., Kurachi, M.: "Lack of self-control as assessed by a personalitu inventory is related to reduced volume of supplementary motor area"Psychiatry Res. Neuroimaging. 116. 53-61 (2002)

[Publications] Kurachi, M.: "Pathogenesis of schizophrenia : PartI. Symptomatology, cognitive characteristics and brain morphology"Psychiatry Clin. Neurosci.. 57. 3-8 (2003)

[Publications] Kurachi, M.: "Pathogenesis of schizophrenia : PartII. Temporo-frontal two-step hypothesis"Psychiatry Clin. Neurosci.. 57. 9-16 (2003)

[Publications] Takahashi, T., Suzuki, M., Kawasaki, Y., Hagino, H., Yamashita, I., Nohara, S., Nakamura, K., Seto, H., Kurachi, M.: "Perigenual cingulated gyrus volume in patients with schizophrenia : a magnetic resonance imaging study"Biol. Psychiatry. (in press).

[Publications] Tonoya, Y., Matsui, M., Kurachi, M., Kurokawa, K., Sumiyoshi, T.: "Exploratory eye movements in schizophrenia : effects of figure size and the instruction on visual search"Eur. Arch. Psychiatry Clin. Neurosci.. (in press).

[Publications] Yotsutsuji, T., Saito, O., Suzuki, M., Hagino, H., Mori, K., Takahashi, T., Kurokawa, K., Matsui, M., Seto, H., Kurachi, M.: "Quantification of lateral ventricular subdivisions in schizophrenia by high-resolution three-dimensional MR imaging"Psychiatry Res. Neuroimaging. (in press).

[Publications] Zhou, S-Y., Suzuki, M., Hagino, H., Takahashi, T., Kawasaki, Y., Nohara, S., Yamashita, I., Seto, H., Kurachi, M.: "Decreased Volume and Increased Asymmetry of the Anterior Limb of the Internal Capsule in Patients with Schizophrenia"Biol. Psychiatry. (in press).

[Publications] 山下委希子, 松井三枝, 倉知正佳, 野原 茂, 高橋 努, 米山英一, 加藤 奏, 黒川賢造: "分裂病型障害患者と精神分裂病患者の神経心理学的プロフィールの比較"精神医学. 44. 845-851 (2002)

[Publications] Kurokawa, M., Tsurita, M., Brown, J., Fukuda, Y., Shiraki, K.: "Effect of interleukin-12 level augmented by Kakkon-to, an herbal medicine, on the early stage of influenza infection in mice"Antiviral Res.. 56. 183-188 (2002)

[Publications] Akanitapichat, P., Kurokawa, M., Tewtrakul, S., Pramyothin, P., Sripanidkulchai, B., Shiraki, K., Hattori, M.: "Inhibitory activities of Thai medicinal plants against herpes simplex type 1, poliovirus type 1, and measles virus"J. Traditional Med.. 19. 174-180 (2002)

[Publications] Takasaki, I., Sasaki, A., Andoh, T., Nojima, H., Shiraki, K., Kuraishi, Y.: "Effects of analgesics on delayed postherpetic pain in mice"Anesthesiology. 96. 1168-1174 (2002)

[Publications] Ohsaki, M., Kurokawa, M., Nawawi, A., Nakamura, N., Hattori, M., Shiraki, K.: "Characterization of anti-herpes simplex virus type 1 activity of an alkaloid FK 3000 from Stephania cepharantha"J. Traditional Med.. 19. 129-136 (2002)

[Publications] Furuta, Y., Takahashi, K., Fukuda, Y., Kuno, M., Kamiyama, T., Kozaki, K., Nomura, N., Egawa, H., Minami, S., Watanabe, Y., Narita, H., Shiraki, K.: "In vitro and in vivo activities of anti-influenza viral compound T-705"Antimicrob. Agents Chemother.. 46. 977-981 (2002)

[Publications] Phumiamorn, S., Sato, H., Kamiyama, T., Kurokawa, M., Shiraki, K.: "Induction of humoral and cell-mediated immunity to hepatitis B surface antigen by a novel adjuvant activity of Oka varicella vaccine"J. Gen. Virol.. 84. 287-291 (2003)

[Publications] Fukuda, Y., Yamamura, J., Uwano, T., Nishijo, H., Kurokawa, M., Fukuda, M., Ono, T., Shiraki, K.: "Regulated transgene delivery by ganciclovir in the brain without physiological alterations by a live attenuated herpes simplex virus vector"Neuroscience Res.. 45. 233-241 (2003)

[Publications] Kataoka, K., Huh, N.: "A novel b1, 3-N-acetylglucosaminyltransferase involved inÅ@invasion of cancer cells as assayed in vitro"Bichem. Biophys. Res. Commun.. 294(4). 843-848 (2002)

[Publications] Ogawa, H., Gomi, T., Takusagawa, F., Masuda, T., Goto, T., Huh, N.: "Evidence for a dimeric structure of rat liver serine dehydratase"Int. J. Biochem. Cell Biol.. 34(5). 533-543 (2002)

[Publications] Kondo, A., Sakaguchi, M., Makino, E., Namba, M., Okada, S., Huh, N.: "Localization of S100C immunoreactivity in various human tissues"Acta Med. Okayama. 56(1). 31-34 (2002)

[Publications] Huh, W.K., Oono, T., Shirafuji, Y., Akiyam, H., Arata, J., Sakaguchi, M., Huh, N., Iwatsuki, K.: "Dynamic alteration of human β-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin"J. Mol. Med.. 80(10). 678-684 (2002)

[Publications] Miyazaki, M., Akiyama, I., Sakaguchi, M., Nakashima, E., Okada, M., kataoka, K., Huh, N.: "Improved conditions to induce hepatocytes from rat bone marrow cells in culture"Biochem. Biophys. Res. Commun.. 298(1). 24-30 (2002)

[Publications] Shibakura, M., Niiya, K., Kiguchi, T., Kitajima, I., Niiya, M., Asami, N., Huh, N., Nakata, Y., Harada, M., Tanimoto, M.: "Induction of interleukin-8 and monocyte chemoattractant protein-1 by doxorubicin in human small-cell lung carcinoma cells"Int. J. Cancer. 103(3). 380-386 (2003)

[Publications] Nakajima, A., Kataoka, K., Hong, M., Sakaguchi, M., Huh, N.: "BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential"Cancer Lett.. (in press).

[Publications] Makino, T., Takaishi, M., Toyoda, T., Morohashi, M., Huh, N.: "Expression of Hornerin in Stratified Squamous Epithelium in the Mouse : A Comparative Analysis with Profilaggrin"J. Histochem. Cytochem.. (in press).

[Publications] Takaishi, M., Ishisaki, Z., Yoshida, T., Huh, N.: "Expression of calmin, a novel developmentally regulated brain protein with calponin-homology domains"Mol. Brain Res.. (in press).

[Publications] Kishi, H., Jin, Z-X., Wei, X-C., Nagata, T., Matsuda, T., Saito, S., Muraguchi, A.: "Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells"Blood. 99. 576-583 (2002)

[Publications] Nagata, T., Kishi, H., Liu, Q-L., Matsuda, T., Imanaka, T., Tsukada, K., Kang, D., muraguchi, A.: "The regulation of DNAse activities in subcellular compartments of activated thymocytes"Immunology. 105. 339-406 (2002)

[Publications] Wei, X-C., Kishi, H., Zhao, W-P., Kondo, S., Matsuda, T., Saito, S., Muraguchi, A.: "Characterization of chromatin structure and enhancerelements for murine recombination activating gene-2"J. Immunol.. 169. 873-881 (2002)

[Publications] Jin, Z-X., Kishi, H., Wei, X-C, Matsuda, T., Saito, S., Muraguchi, A.: "LEF-1 binds and activates the RAG-2 promoter together with c-Myb and Pax-5 in immature B cells"J. Immunol.. 169. 3783-3792 (2002)

[Publications] 川崎康弘, 鈴木道雄, 中村主計, 倉知正佳: "形態画像.特集「臨床検査による精神科診断はどこまで可能となったか」"精神科診断学. 13(2). 145-152 (2002)

[Publications] 許 南浩: "ES細胞"岡山医学会雑誌. 114(1). 59-61 (2002)

[Publications] Nishijo, H., Hori, E., Tazumi, T., Eifuku, S., Umeno, K., Tabuchi, E., Ono, T.: "Role of the monkey amygdala in social cognition. In : Cognition and Emotion in the Brain"Elsevier (in press).

[Publications] Eifuku, S., De Souza, W.C., Tamura, R., Nishijo, H., Ono, T.: "On the organization of face memory. In : Cognition and Emotion in the Brain"Elsevier (in press).

[Publications] Tran, A.H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., Ono, T.: "Dopamine D2 receptor-knockout changed accumbens neural response to prediction of reward associated with place in mice. In : Cognition and Emotion in the Brain"Elsevier (in press).

[Publications] Komura, Y., Tamura, R., Uwano, T., Nishijo, H., Ono, T.: "Transmodal coding for reward prediction in the audiovisual thalamus. In : Cognition and Emotion in the Brain"Elsevier (in press).

[Publications] 西条寿夫, 小野武年: "情動のメカニズムと大脳辺縁系 セラピストのための基礎研究論文集(4)「人間行動と皮質下機能」第3部大脳辺縁系と情動・動機づけ,永井洋一 編"協同医書出版社. 233-266 (2002)

[Publications] 上野照子, 小野武年: "扁桃体と情動 セラピストのための基礎研究論文集(4)「人間行動と皮質下機能」第3部大脳辺縁系と情動・動機づけ, 永井洋一 編"協同医書出版社. 295-318 (2002)

[Publications] 小野武年, 西条寿夫: "大脳辺縁系・大脳基底核における情と意の出力機構-本能, 情動, 生きる喜び-「情と意の脳科学-人とは何か」,1.情と意の脳神経構築,松本 元 小野武年 共編"培風館. 2-25 (2002)

[Publications] 西条寿夫, 小野武年: "情と意における大脳辺縁系と連合野の役割-生物学的価値評価,行動戦略の決定-「情と意の脳科学-人とは何か」,1.情と意の脳神経構築,松本 元 小野武年 共編"培風館. 46-67 (2002)

[Publications] 西条寿夫, 小野武年: "摂食行動 基礎 栄養学 第5版,吉田勉 編著"医歯薬出版. 174-178 (2003)

[Publications] 小野武年, 上野照子: "情動 脳神経科学"三輪書店 (印刷中).

[Publications] 田村了以, 小野武年: "快・不快の神経機構 脳の科学"星和書店 (印刷中).

[Publications] 倉知正佳, 川崎康弘: "統合失調症の病態形成と脳の発達 新世紀の精神科治療 第1巻 統合失調症の診断学"中山書店. 30-39 (2002)

[Publications] 倉知正佳: "精神分裂病:自我と社会性の脳内機構. 「情と意の脳科学」,松本 元,小野武年共編"培風館. 174-189 (2002)

[Publications] 許 南浩: "バイオ人工皮膚. 現代化学増刊「再生医学・再生医療」,室田誠逸編"東京化学同人. 211-213 (2002)

小野武年富山医科薬科大学, 医学部, 教授 (50019577)

[Publications] 数井健一, 佐々木和男, 堀悦郎, 田渕英一, 梅野克身, 小野武年, 西条寿夫: "仮想現実空間探索課題におけるサル海馬体ニューロンの応答性"信学技報(電子情報通信学会技術研究報告). MBE. 3-5 (2002)

[Publications] 山下委希子, 松井三枝, 倉知正佳, 野原茂, 高橋努, 米山英一, 加藤奏, 黒川賢造: "分裂病型障害患者と精神分裂病患者の神経心理学的プロフィールの比較"精神医学. 44. 845-851 (2002)

[Publications] 許南浩: "ES細胞"岡山医学会雑誌. 114(1). 59-61 (2002)

[Publications] 西条寿夫, 小野武年: "情動のメカニズムと大脳辺縁系セラピストのための基礎研究論文集(4)「人間行動と皮質下機能」第3部大脳辺縁系と情動・動機づけ,永井洋一編"協同医書出版社. 233-266 (2002)

[Publications] 上野照子, 小野武年: "扁桃体と情動セラピストのための基礎研究論文集(4)「人間行動と皮質下機能」第3部大脳辺縁系と情動・動機づけ, 永井洋一編"協同医書出版社. 295-318 (2002)

[Publications] 小野武年, 西条寿夫: "大脳辺縁系・大脳基底核における情と意の出力機構-本能, 情動, 生きる喜び-「情と意の脳科学-人とは何か」,1.情と意の脳神経構築,松本元小野武年共編"培風館. 2-25 (2002)

[Publications] 西条寿夫, 小野武年: "情と意における大脳辺縁系と連合野の役割-生物学的価値評価,行動戦略の決定-「情と意の脳科学-人とは何か」,1.情と意の脳神経構築,松本元小野武年共編"培風館. 46-67 (2002)

[Publications] 西条寿夫, 小野武年: "摂食行動基礎栄養学第5版,吉田勉編著"医歯薬出版. 174-178 (2003)

[Publications] 小野武年, 上野照子: "情動脳神経科学"三輪書店 (印刷中).

[Publications] 田村了以, 小野武年: "快・不快の神経機構脳の科学"星和書店 (印刷中).

[Publications] 倉知正佳, 川崎康弘: "統合失調症の病態形成と脳の発達新世紀の精神科治療第1巻統合失調症の診断学"中山書店. 30-39 (2002)

[Publications] 倉知正佳: "精神分裂病:自我と社会性の脳内機構. 「情と意の脳科学」,松本元,小野武年共編"培風館. 174-189 (2002)

[Publications] 許南浩: "バイオ人工皮膚. 現代化学増刊「再生医学・再生医療」,室田誠逸編"東京化学同人. 211-213 (2002)