Neural mechanisms of the limbic system where emotional, memory and immunological systems interact

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 12210009
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Toyama Medical and Pharmaceutical University
• Principal Investigator: NISHIJO Hisao Toyama Medical and Pharmaceutical University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00189284)
• Co-Investigator(Kenkyū-buntansha): SHIRAKI Kimiyasu Toyama Medical and Pharmaceutical University, Faculty of Medicine, Professor, 医学部, 教授 (50135745) ; MURAGUCHI Atsushi Toyama Medical and Pharmaceutical University, Faculty of Medicine, Professor, 医学部, 教授 (20174287) ; KURACHI Masayoshi Toyama Medical and Pharmaceutical University, Faculty of Medicine, Professor, 医学部, 教授 (80019603) ; HUH Nam-Ho Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor, 大学院医歯薬学総合研究所, 教授 (70173573) ; OHTANI Osamu Toyama Medical and Pharmaceutical University, Faculty of Medicine, Professor, 医学部, 教授 (90127548)
• Project Period (FY): 2004
• Keywords: Emotion / Memory / Cognition / Immunity / Limbic System / Neuronal Activity / Cytokine / Behavior

Research Abstract

We have investigated limbic mechanisms on emotion, memory and immune responses from molecular to behavior levels.
1. Neurophysiological study: Monkey hippocampal formation (HF) neurons were recorded during virtual navigation. Some neurons responded before or after the reward delivery only in specific areas of a specific virtual space. Activity of the other type of the HF neurons increased during navigation in specific directions. These HF neurons with spatial correlates showed different responses in different virtual spaces. These specific features of the monkey HF neurons might underlie neurophysiological bases of the human episodic memory.
2. Neuroanatomical Study: Excessive dopaminergic neurotransmission in the limbic system, particularly the amygdala has been suggested to be responsible for development of schizophrenia. In this study we examined expression of dopamine D2 receptors in the basolateral (BL) nucleus of the rat amygdala by double immuno-electron microscopy and confocal la ser scanning microscopy. We showed GABA neurons in the BL express dopamine D2 receptors, and that the dopamine system in the BL modulates GABA interneurons, which in turn, exert inhibitory influence on projection neurons of the BL. The DA system also directly influences on the projection neurons which are presumably glutamatergic.
3. Molecular biological study: 1) We analyzed the expression of neurocan that is known to inhibit axonal elongation. The results indicate that neurocan may be involved in the regulation of axonal elongation after brain infarction. 2) We investigated the role of IL-1 beta and IL-18, proinflammatory cytokines that are activated by IL-1 beta converting enzyme (ICE), in kainic acid (KA)-induced ataxia. 3) To introduce genes of neurotropic factors into the limbic system, we inserted those genes in the internal inverted repeat region connected to UL55 promoter region of a Herpes simplex virus (HSV) vector.
4. Neuropsychological study: Schneider's first rank symptoms (auditory hallucination and disturbance of self), which are characteristic of Schizophrenia, were reported to be related to volume reductions in the parahippocampal gyrus and cingulate gyrus. To clarify the neuroanatomical correlates for development of schizophrenia, MRI-based brain morphology was compared between patients with schizophrenia and schizotypal disorder. Volume reductions in the amygdala and hippocampus common to both disorders may represent the vulnerability to schizophrenia, while prefrontal volume loss observed preferentially in schizophrenia may be a critical factor for overt manifestation of this psychosis.

Research Products

• [Journal Article] Effects of prenatal maternal stress by repeated cold environment on behavioral and emotional development in the rat offspring. (2005)
  • Author(s): Tazumi, T., Hori, E., Uwano, T., Umeno, K, Tanabe, K., Tabuchi.E., Ono, T., Nishijo,H.
  • Journal Title: Behav. Brain Res. 162 Pages: 153-160
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of facial expression on shared attention mechanisms. (2005)
  • Author(s): Hori, E., Tazumi, T., Tabuchi, E., Umeno, K., Kamachi, M., Ono, T., Nishijo,H.
  • Journal Title: Physiol. Behav. 84 Pages: 397-405
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of cadmium exposure during pregnancy on trace elements in fetal rat liver and kidney. (2005)
  • Author(s): Kuriwaki, J., Nishijo, M., Honda, R., Tawara, K., Nakagawa, H., Hori, E., Nishijo,H.
  • Journal Title: Toxicol. Lett. 156 Pages: 369-376
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 天然匂い物質"セドロール"吸入による自律神経反応 (2005)
  • Author(s): Samantha Davawansa, 梅野克身, 矢田幸博, 永嶋義直, 小野武年, 西条寿夫
  • Journal Title: アロマセラピー学会誌 4 Pages: 17-21
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 前頭前野と情動発現 (2005)
  • Author(s): 小野武年, 西条寿夫
  • Journal Title: クリニカルニューロサイエンス 23 Pages: 636-639
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential characteristics of face neuron responses within the anterior superior temporal sulcus of macaques. (2005)
  • Author(s): DeSouza, W.C., Eifuku, S., Tamura, R., Nishijo, H., Ono.T.
  • Journal Title: J. Neurophysiol. 94 Pages: 1252-1266
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Place-related neural responses in the monkey hippocampal formation i a virtual space. (2005)
  • Author(s): Hori, E., Nishio, Y., Kazui, K., Umeno, K., Tabuchi, E., Sasaki, K., Endo, S., Ono, T., Nishijo, H.
  • Journal Title: Hippocampus 15 Pages: 991-996
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of prenatal maternal stress by repeated cold environment on behavioral and emotional development in the rat offspring. (2005)
  • Author(s): Tazumi, T., Hori, E., Uwano, T., Umeno, K, Tanabe, K., Tabuchi, E., Ono, T., Nishijo, H.
  • Journal Title: Behav Brain Res 162 Pages: 153-160
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of facial expression on shared attention mechanisms. (2005)
  • Author(s): Hori, E., Tazumi, T., Tabuchi, E., Umeno, K., Kamachi, M., Ono, T., Nishijo, H.
  • Journal Title: Physiol Behav 84 Pages: 397-405
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of cadmium exposure during pregnancy on trace elements in fetal rat liver and kidney. (2005)
  • Author(s): Kuriwaki, J., Nishijo, M., Honda, R., Tawara, K., Nakagawa, H., Hori, E., Nishijo, H.
  • Journal Title: Toxicol Lett 156 Pages: 369-76
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential characteristics of face neuron responses within the anterior superior temporal sulcus of macaques. (2005)
  • Author(s): DeSouza, WC., Eifuku, S., Tamura, R., Nishijo, H., Ono, T.
  • Journal Title: J neurophysiol 94 Pages: 1252-1266
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Place-Related neural responses in the monkey hippocampal formation in a virtual space. (2005)
  • Author(s): Hori, E., Nishio, Y, Kazui, K., Umeno, K., Tabuchi, E., Sasaki, K., Endo, S., Ono, T., Nishijo, H.
  • Journal Title: Hippocampus 15 Pages: 991-996
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autonomic responses during inhalation of natural flagrance of "CEDROL" in humans. (2005)
  • Author(s): Dayawansa, S., Umeno, K., Yada, Y., Nagashima, Y., Ono, T., Nishijo, H.
  • Journal Title: Journal of Japanese Society of Aromatherapy 4 Pages: 17-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prefrontal cortex and emotional expression. (2005)
  • Author(s): Ono, T., Nishijo, H.
  • Journal Title: Clinical Neuroscience 23 Pages: 636-639
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of non-saponin fraction of red ginseng on learning deficits in aged rats. (2004)
  • Author(s): Kurimoto, H., Nishijo, H., Uwano, T., Yamaguchi, H., Zhong, Y-M., Kawanishi, K., Ono,T.
  • Journal Title: Physiol. Behav. 82 Pages: 345-355
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Comparison of brain activity between dopamine d2 receptor-knockoutand wild mice in response to dopamine agonist and antagonist assessed by FMRI. (2004)
  • Author(s): Kuriwaki, J., Nishijo, H., Kondoh, T., Uwano, T., Torii, K, Katsuki, M., Ono T.
  • Journal Title: Neurosignals 13 Pages: 227-240
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Neuronal correlates of face identification in the monkey anterior temporal cortical areas. (2004)
  • Author(s): Eifuku, E., De, Souza, W.C., Tamura, R., Nishijo, H., Ono,T.
  • Journal Title: J. Neurophysiol. 91 Pages: 358-371
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia. (2004)
  • Author(s): Yokoyama, K., Shimada, Y., Hori, E., Nakagawa, T., Takagi, S., Sekiya, N., Kouta, K., Nishijo, H., Yokozawa, T., Terasawa K.
  • Journal Title: J. Ethnopharmacol. 95 Pages: 335-343
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Protective effects of choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil. (2004)
  • Author(s): Yokoyama, K., Shimada, Y., Hori, E., Sekiya, N., Goto, H., Sakakibara, I., Nishijo, H., Terasawa K.
  • Journal Title: Phytomedicine 11 Pages: 478-489
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Proof of the mysterious efficacy of Ginseng basic and clinical trials effects of red Ginseng : on learning and memory deficits in an animal model of amnesia. (2004)
  • Author(s): Nishijo, H., Uwano, T., Zhuong, Y-M., Ono,T.
  • Journal Title: J. Pharmacol. Sci. 95 Pages: 145-152
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 双極子追跡法によるに視覚認知機能に関わる脳内電流発生源の推定 (2004)
  • Author(s): 西条寿夫, 柴田 孝, 小野武年
  • Journal Title: 臨床脳波 46 Pages: 778-784
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 大脳機能の新しいパースペクティブ : 社会的認知と情動発現 偏桃体と前頭葉の役割 (2004)
  • Author(s): 堀 悦郎, 西条寿夫, 小野武年
  • Journal Title: 脳と神経 56 Pages: 109-120
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 扁桃体における情動学習の神経・分子機構 (2004)
  • Author(s): 西条寿夫, 小野武年
  • Journal Title: Molecular Medicine 41 Pages: 1136-1148
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 食物報酬の認知と摂食行動の神経機構 (2004)
  • Author(s): 西条寿夫, 田渕英一, 小野武年
  • Journal Title: 肥満研究 10 Pages: 4-11
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 自己の情動反応の表出と他個体の情動反応の認知における扁桃体の役割-動物を対象にした侵襲的脳研究の動向- (2004)
  • Author(s): 田積 徹, 西条寿夫, 小野武年
  • Journal Title: 心理学評論 47 Pages: 8-28
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of non-saponin fraction of red ginseng on learning deficits in aged rats. (2004)
  • Author(s): Kurimoto, H., Nishijo, H., Uwano, T., Yamaguchi, H., Zhong, Y-M., Kawanishi, K., Ono, T.
  • Journal Title: Physiol Behav 82 Pages: 345-355
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of brain activity between dopamine d2 receptor-knockout and wild mice in response to dopamine agonist and antagonist assessed by FMRI. (2004)
  • Author(s): Kuriwaki, J., Nishijo, H., Kondoh, T., Uwano, T., Torii, K., Katsuki, M., Ono, T.
  • Journal Title: Neuro Signals 13 Pages: 227-240
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuronal correlates of face identification in the monkey Anterior temporal cortical areas. (2004)
  • Author(s): Eifuku, E., De, Souza, W.C., Tamura, R., Nishijo, H., Ono, T.
  • Journal Title: J Neurophysiol 91 Pages: 358.371
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia. (2004)
  • Author(s): Yokoyama, K., Shimada, Y., Hori, E., Nakagawa, T., Takagi, S., Sekiya, N., Kouta, K., Nishijo, H., Yokozawa, T., Terasawa, K.
  • Journal Title: J Ethnopharmacol 95 Pages: 335-343
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protective effects of choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil. (2004)
  • Author(s): Yokoyama, K., Shimada, Y., Hori, E., Sekiya, N., Goto, H., Sakakibara, I., Nishijo, H,.Terasawa, K.
  • Journal Title: Phytomedicine 11 Pages: 478-489
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Proof of the mysterious efficacy of Ginseng basic and clinical trials effects of red Ginseng : on learning and memory deficits in an animal model of amnesia. (2004)
  • Author(s): Nishijo, H., Uwano, T., Zhuong, Y-M., Ono, T.
  • Journal Title: J Pharmacol Sci 95 Pages: 145-152
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Localization of current source generators involved in visual recognition by means of the dipole tracing method (2004)
  • Author(s): Nishijo, H., Shibata, T, Ono, T.
  • Journal Title: Rinsyou Nouha 46 Pages: 778-784
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A role of the amygdala and frontal lobe in social cognition and emotion. (2004)
  • Author(s): Hori, E., Nishijo, H., Ono, T.
  • Journal Title: Nou to Shinkei 56 Pages: 109-120
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neural and molecular mechanisms of emotional learning in the amygdala. (2004)
  • Author(s): Nishijo, H., Ono, T.
  • Journal Title: Molecular Medicine 41 Pages: 1136-1148
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neural mechanisms for cognition of food reward and food (2004)
  • Author(s): Nishijo, H., Tabuchi, E., Ono, T.
  • Journal Title: Journal of Japan Society for the Study of Obesity 10 Pages: 4-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A role of the amygdala in emotional expression and recognition of emotional responses expressed by other individuals (2004)
  • Author(s): Tazumi, T., Nishijo, H., Ono, T.
  • Journal Title: Japanese Psychological Review 47 Pages: 8-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neural mechanisms of emotion. In : Disorders of higher brain function. Eds ; Yanagisawa, N., Shinohara, Y, Iwata, M., Shimizu, T., Teramoto, A. (2004)
  • Author(s): Hori, E., Nishijo, H., Ono, T.
  • Journal Title: Annual Review Neuroscience Pages: 327-339
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Annual Review神経2004 XVII.高次脳機能障害 2.情動の神経機構(柳澤信夫,篠原幸人,岩田 誠,清水輝夫,寺本 明編集) (2004)
  • Author(s): 堀 悦郎, 西条寿夫, 小野武年
  • Total Pages: 368
  • Publisher: 中外医学社
  • Description: 「研究成果報告書概要(和文)」より