Characterization of genetic alterations in human cancer and its application for diagnosis and treatment

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 12213010
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: HORIII Akira Tbhoku University School of Medicine, Professor, 大学院医学系研究科, 教授 (40249983)
• Co-Investigator(Kenkyū-buntansha): YAEGASHI Nobuo Tohoku University, School of Medicine, Professor, 大学院医学系研究科, 教授 (00241597) ; SUNAMURA Makoto Tohoku University, Hospital, Lecturer, 病院・講師 (10201584)
• Project Period (FY): 2000 – 2004
• Keywords: Pancreatic cancer / DUSP6 / AURKA / RNAi / Micro array / Malignant melanoma / BRAF / Wnt

Research Abstract

In human pancreatic cancer, frequent loss of lp, 12q, and 18q, and gain of 20q are observed. We analyzed these regions in this study. RAW a candidate tumor suppressor gene that encodes a protein specifically binds to RB protein. This gene localizes in 1p36, and we found mutations of this gene in pancreatic cancer. This may be a target tumor suppressor gene in human pancreatic cancer.
In 12q, we previously detected frequent loss of expression of DUSP6 This gene encodes a protein that specifically inactivates ERK Overexpression of DUSP6 protein was frequently observed in precursor lesions of pancreatic cancer However, expression gradually decreases according to progression of carcinogenesis. The main mechanisms of loss of expression were epigenetic modification, and adeno-virus mediated expression caused apoptosis. On the other hand, chromosome 12 transfer induced growth suppression in vivo, but suppressed DUSP6expression did not recover. We further discovered that suppression of angiogen esis was one of the main mechanisms of growth suppression. Microarray analysis identified several candidate genes, and further analyses will lead to the responsible gene for angiogenesis inhibition.
Loss of 18q is also frequently observed early event in human pancreatic cancer, but SMAD4 does not mutate at the early stage. Moreover introduction of SMAD4 did not suppress cell growth in vitro. After chromosome transfer, however, growth suppression was prominent in vitro. Suppression of metastasis was also observed in our mice model Microarray analysis also suggested some candidate genes, and we are on the way of further characterization.
Frequent gain of 20q was observed in human pancreatic cancer. We analyzed AURKA on this arm and frequent overexpression was observed. We further performed siRNA-mediated knockdown and observed growth suppression and induction of apoptosis. Moreover, synergistic enhancement of knockdown of AURKA with taxane was observed.
Beta-catenin is one of the oncogenes in several human cancers. We found frequent abnormal accumulation of beta-catenin in human pituitary adenomas. However, mutation was not so frequent We also analyzed other genes that play in the Wnt pathway such as APC, AXINI, GSK3B, and ICAT, but mutations in these genes were not observed.
BRAF is a recently detected oncogene in human melanoma. We also performed mutation analysis in this gene in melanomas, but mutation frequency was not high when compared with that of Caucasians. However, distinct mutation frequencies were found by the histopathological subtypes. This may be the reason of difference in mutation frequency.
Frequent missense mutation of hMLH1 was observed and accurate evaluation is important We developed effective and quite accurate monitoring system using yeast two-hybrid system. We also analyzed MBD4 that was thought to work in the DNA repair system. We found that this protein works as one of the transcription repressors associated with methylation.

Research Products

• [Journal Article] Comparative genomic hybridization and mutation analyses of sporadic schwannomas (2005)
  • Author(s): Ikeda T, Hashimoto S, Fukushige S, Ohmori H, Horii A
  • Journal Title: J Neuro-Oncol (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1 (2005)
  • Author(s): Sun C, Yamato T, Kondo E, Furukawa T, Ikeda H, Horii A
  • Journal Title: J Neuro-Oncol (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas. (2005)
  • Author(s): Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A
  • Journal Title: Mod Pathol (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Computed tomographic images reflect the biological behavior of small lung adenocarcinoma; They correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix and K-ras mutation. (2005)
  • Author(s): Dong B, Sato M, Sakurada A, Sagawa M, Endo C, Wu S, Yamanaka S, Horii A, Kondo T
  • Journal Title: J Thorac Cardiovasc Surg (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. (2005)
  • Author(s): Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y, Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y
  • Journal Title: Int J Cancer (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells (2005)
  • Author(s): Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A
  • Journal Title: Cancer Res 65 Pages: 2899-2905
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. (2005)
  • Author(s): Xu S, Furukawa T, Kanai N, Sunamura M, Horii A
  • Journal Title: J Hum Genet 50 Pages: 159-167
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16^<INK4a> and MLH1 genes. (2005)
  • Author(s): Kondo E, Gu Z, Horii A, Fukushige S
  • Journal Title: Mol Cell Biol 25 Pages: 4388-4396
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] In frequent mutation of APQ, AXIN1, and GSK3B In human pituitary adenomas with abnormal accumulation of CTNNBI. (2005)
  • Author(s): Sun C, Yamato T, Kondo E, Furukawa T, Ikeda H, Horii A.
  • Journal Title: J Neuro-Oncol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas. (2005)
  • Author(s): Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A.
  • Journal Title: Mod Pathol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative genomic hybridization and mutation analyses of sporadic schwannomas. (2005)
  • Author(s): Ikeda T, Hashimoto S, Fukushige S, Ohmori H, Horii A.
  • Journal Title: J Neuro-Oncol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Computed tomographic images reflect the biological behavior of small lung adenocarcinoma; They correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix and K-ras mutation. (2005)
  • Author(s): Dong B, Sato M, Sakurada A, Sagawa M, Endo C, Wu S, Yamanaka S, Horii A, Kondo T.
  • Journal Title: J Thorac Cardiovasc Surg (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. (2005)
  • Author(s): Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y,. Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y.
  • Journal Title: Int J Cancer (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Role of DUSP6/MKP-3 in Pancreatic Carcinoma. In : Hayat MA (ed.) Handbook of immunohistochemistry and in situ hybridization of human carcinomas, volume 3 : Molecular genetics, liver carcinoma, and pancreatic carcinoma (2005)
  • Author(s): Furukawa T, Horii A.
  • Journal Title: Elsevier (USA), Philadelphia, PA (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. (2005)
  • Author(s): Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A.
  • Journal Title: Cancer Res 65 Pages: 2899-2905
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Abrogation of DUSP6by hypermethylation in human pancreatic cancer. (2005)
  • Author(s): Xu S, Furukawa T, Kanai N, Sunamura M, Horii A.
  • Journal Title: J Hum Genet 50 Pages: 159-167
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p167NK4a and MLHI genes. (2005)
  • Author(s): Kondo E, Gu Z, Horii A, Fukushige S.
  • Journal Title: Mol Cell Biol 25 Pages: 4388-4396
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. (2004)
  • Author(s): Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T
  • Journal Title: Int J Oncol 24 Pages: 513-520
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin (2004)
  • Author(s): Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T
  • Journal Title: Biosci Biotecnnol Biochem 68 Pages: 1004-1010
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes. (2004)
  • Author(s): Furukawa T, Horii A
  • Journal Title: Pancreas 28 Pages: 253-256
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma. (2004)
  • Author(s): Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S
  • Journal Title: Pancreas 28 Pages: 311-316
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Screening for functional tumor suppressor activity in pancreatic cancer. (2004)
  • Author(s): Lefter L, Scripcaru V, Sunamura M, Furukawa T, Matsuno S, Oshimura M, Drug V, Dragomir C, Horii A
  • Journal Title: Rom J Gastroenterol 13 Pages: 195-201
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. (2004)
  • Author(s): Yatsuoka T, Furukawa T, Sunamura M, Matsuno S, Horii A
  • Journal Title: Oncol Rep 12 Pages: 1263-1268
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin. (2004)
  • Author(s): Imai M, Nakamura T, Akiyama T, Horii
  • Journal Title: Oncol Rep 12 Pages: 1099-1103
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor suppressor gene that suppresses angiogenesis. (2004)
  • Author(s): Yamanaka S, Sunamura M, Furukawa T, Sun L, Lefter LP, Abe T, Yatsuoka T, Fujimura H, Shibuya E, Kotobuki N, Oshimura M, Sakurada A, Sato M, Kondo T, Matsuno S, Horii A
  • Journal Title: Lab Invest 84 Pages: 1339-1351
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] BRAF point mutations in primary malignant melanoma show different prevalences by subtype. (2004)
  • Author(s): Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A
  • Journal Title: J Invest Dermatol 123 Pages: 177-183
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional Analysis of chromosome 18 in pancreatic cancer : strong evidence for new tumour suppressor genes. (2004)
  • Author(s): Lefter LP, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S
  • Journal Title: Asian J Surg 27 Pages: 85-92
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes. (2004)
  • Author(s): Furukawa, T., Horii, A.
  • Journal Title: Pancreas 28 Pages: 253-256
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma. (2004)
  • Author(s): Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S.
  • Journal Title: Pancreas 28 Pages: 311-316
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. (2004)
  • Author(s): Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T.
  • Journal Title: Int J Oncol 24 Pages: 513-520
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin" (2004)
  • Author(s): Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T.
  • Journal Title: Biosci Biotecnnol Biochem 68 Pages: 1004-1010
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] BRAF point mutations in primary malignant melanoma show different prevalences by subtype " (2004)
  • Author(s): Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A.
  • Journal Title: J Invest Dermatol 123 Pages: 177-183
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] FunctionalAnalysisofchromosome18inpancreaticcancer : strong evidence for new tumour suppressor genes. (2004)
  • Author(s): Lefter LP, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S.
  • Journal Title: Asian J Surg 27 Pages: 85-92
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor suppressor gene that suppresses angiogenesis. (2004)
  • Author(s): Yamanaka S, Sunamura M, Furukawa T, Sun L, Lefter LP, Abe T, Yatsuoka T, Fujimura H, Shibuya E, Kotobuki N, Oshimura M, Sakurada A, Sato M, Kondo T, Matsuno S, Horii A.
  • Journal Title: Lab lnvest 84 Pages: 1339-1351
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of (3).catenin. " (2004)
  • Author(s): Imai M, Nakamura T, Akiyama T, Horii
  • Journal Title: Oncol Rep 12 Pages: 1099-1103
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. (2004)
  • Author(s): Yatsuoka T, Furukawa T, Sunamura M, Matsuno S, Horii A.
  • Journal Title: Oncol Rep 12 Pages: 1263-1268
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast. (2003)
  • Author(s): Aamari, M., Horiya, T., Ishida, T., Harada, Y., Ohnuki K., Takeda, M., Sasano, H., Horii, A., Ohuchi, N.
  • Journal Title: Jpn J Clin Oncol 33 Pages: 556-562
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype. (2003)
  • Author(s): Lefter LP, Sunamura M, Furukawa T, Takeda K, Kotobuki N, Oshimura M, Matsuno S, Horii A
  • Journal Title: Clin Cancer Res 9 Pages: 5044-5052
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] APAF-l-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line. (2003)
  • Author(s): Ogawa T, Shiga K, Hashimoto S, Kobayashi T, Horii A, Furukawa T
  • Journal Title: Biochem Biophys Res Commun 306 Pages: 537-543
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. (2003)
  • Author(s): Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, Yatsuoka T, Abe T, Inoue H, Motoi F, Egawa S, Matsuno S, Horii A
  • Journal Title: Oncogene 22 Pages: 6857-6864
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germline mutations. (2003)
  • Author(s): Kondo E, Suzuki H, Horii A, Fukushige S
  • Journal Title: Cancer Res 63 Pages: 3302-3308
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. (2003)
  • Author(s): Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A
  • Journal Title: Am J Pathol 162 Pages: 1807-1815
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma. (2003)
  • Author(s): Kadota M, Tamaki Y, Sekimoto M, Fujiwara Y, Aritake N, Hasegawa S, Kobayashi T, Ikeda T, Horii A, Monden M
  • Journal Title: Oncol Rep 10 Pages: 35-38
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast. (2003)
  • Author(s): Amari, M., Moriya, T., Ishida, T., Harada, Y., Ohnuki, K., Takeda, M., Sasano, H., Horii, A., Ohuchi, N.
  • Journal Title: Jpn.J.Clin.Oncol. 33 Pages: 556-562
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype. (2003)
  • Author(s): Lefter, L.P., Sunamura, M., Furukawa, T., Takeda, K., Kotobuki, N., Oshimura, M., Matsuno, S., Horii, A.
  • Journal Title: Clin.Cancer Res. 9 Pages: 5044-5052
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line. (2003)
  • Author(s): Ogawa, T., Shiga, K., Hashimoto, S., Kobayashi, T., Horii, A., Furukawa, T.
  • Journal Title: Biochem.Biophys.Res.Commun. 306 Pages: 537-543
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. (2003)
  • Author(s): Duda, D.G., Sunamura, M., Lefter, L.P., Furukawa, T., Yokoyama, T., Yatsuoka, T., Abe, T., Inoue, H., Motoi, F., Egawa, S., Matsuno, S., Horii, A.
  • Journal Title: Oncogene 22 Pages: 6857-6864
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germline mutations. (2003)
  • Author(s): Kondo, E., Suzuki, H., Horii, A., Fukushige, S.
  • Journal Title: Cancer Res. 63 Pages: 3302-3308
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. (2003)
  • Author(s): Furukawa, T., Sunamura, M., Motoi, F., Matsuno, S., Horii, A.
  • Journal Title: Am.J.Pathol. 162 Pages: 1807-1815
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma. (2003)
  • Author(s): Kadota, M., Tamaki, Y., Sekimoto, M., Fujiwara, Y., Aritake, N., Hasegawa, S., Kobayashi, T., Ikeda, T., Horii, A., Monden, M.
  • Journal Title: Oncol.Rep. 10 Pages: 35-38
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus. (2002)
  • Author(s): Sunamura M, Oonuma M, Motoi F, Abe H, Saito U, Hoshida T, Ottomo S, Horii A, Matsuno S
  • Journal Title: Hum Cell 15 Pages: 138-150
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers (2002)
  • Author(s): Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J
  • Journal Title: Am J Pathol 161 Pages: 207-216
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A microarray-based method for detecting methylated loci. (2002)
  • Author(s): Hatada I, Kato A, Morita S, Obata Y, Nagaoka K, Sakurada A, Sato M, Horii A, Tsujimoto A, Matsubara K
  • Journal Title: J Hum Genet 47 Pages: 448-451
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. (2002)
  • Author(s): Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S
  • Journal Title: Br J Cancer 86 Pages: 490-496
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines. (2002)
  • Author(s): Lefter LP, Furukawa T, Sunamura M, Duda D, Takeda K, Kotobuki N, Oshimura M, Matsuno S, Horii A
  • Journal Title: Genes Chromosomes Cancer 27 Pages: 234-242
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus. (2002)
  • Author(s): Sunamura, M., Oonuma, M., Motoi, F., Abe, H., Saito, U., Hoshida, T., Ottomo, S., Horii, A., Matsuno, S.
  • Journal Title: Hum.Cell 15 Pages: 138-150
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. (2002)
  • Author(s): Yokoi, S., Yasui, K., Saito-Ohara, F., Koshikawa, K., Iizasa, T., Fujisawa, T., Terasaki, T., Horii, A., Takahashi, T., Hirohashi, S., Inazawa, J.
  • Journal Title: Am.J.Pathol. 161 Pages: 207-216
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A microarray-based method for detecting methylated loci. (2002)
  • Author(s): Hatada, I., Kato, A., Morita, S., Obata, Y., Nagaoka, K., Sakurada, A., Sato, M., Horii, A., Tsujimoto, A., Matsubara, K.
  • Journal Title: J.Hum.Genet. 47 Pages: 448-451
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Overexpression of the p53-inducible brain-specific angiogenesis inhibitor l suppresses efficiently tumour angiogenesis. (2002)
  • Author(s): Duda, D.G., Sunamura, M., Lozonschi, L., Yokoyama, T., Yatsuoka, T., Motoi, F., Horii, A., Tani, K., Asano, S., Nakamura, Y., Matsuno, S.
  • Journal Title: Br.J.Cancer 86 Pages: 490-496
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines. (2002)
  • Author(s): Lefter, L.P., Furukawa, T., Sunamura, M., Duda, D.G., Takeda, K., Kotobuki, N., Oshimura, M., Matsuno, S., Horii, A.
  • Journal Title: Genes Chromosomes Cancer 27 Pages: 234-242
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Allelic loss of the NF1 gene in anal malignant melanoma in a patient with neurofibromatosis type 1 (2001)
  • Author(s): Ishii S, Han S, Shiiba K, Mizoi T, Okabe M, Horii A, Nagura H, Matsuno S, Sasaki I
  • Journal Title: Int J Clin Oncol 6 Pages: 201-204
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36. (2001)
  • Author(s): Chen YZ, Soeda E, Yang HW, Takita J, Chai L, Horii A, Inazawa J, Ohki M, Hayashi Y
  • Journal Title: Genes Chromosomes Cancer 31 Pages: 326-332
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease. (2001)
  • Author(s): Kato N, Kimura K, Sugawara H, Aoyagi S, Ikeda T, Horii A
  • Journal Title: Int J Oncol 18 Pages: 1017-1022
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino-acid residues within hMLH3, hPMS1 and hPMS2. (2001)
  • Author(s): Kondo E, Horii A, Fukushige S
  • Journal Title: Nucl Acids Res 29 Pages: 1695-1702
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis. (2001)
  • Author(s): Kaneko K, Nagasaki Y, Furukawa T, Mizutamari H, Sato A, Masamune A, Shimosegawa T, Horii A
  • Journal Title: J Hum Genet 46 Pages: 293-297
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A BAC-based STS-content map spanning a 35-megabase region of human chromosome 1p35-p36. (2001)
  • Author(s): Chen YZ, Hayashi Y, Wu JG, Takaoka E, Haekawa K, Watanabe N, Inazawa J, Hosoda F, Arai Y, Ohki M, Mizushima H, Morohoshi A, Ohira H, Nakagawara A, Liu S-Y, Hoshi M, Horii A, Soeda, E
  • Journal Title: Genomics 74 Pages: 55-70
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal adenocarcinoma. (2001)
  • Author(s): Inoue H, Furukawa T, Sunamura M, Takeda K, Matsuno S, Horii A
  • Journal Title: Genes Chromosomes Cancer 31 Pages: 295-299
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Isolation and characterization of the human gene homologous to the Drosophila Headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. (2001)
  • Author(s): Makino N, Yamato T, Inoue H, Furukawa T, Abe T, Yokoyama T, Yatsuoka T, Fukushige S, Orikasa S, Takahashi T, Horii A
  • Journal Title: DNA Seq 11 Pages: 547-553
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Human BAC contig covering the deleted region in pancreatic cancer at 12q21. (2001)
  • Author(s): Youssef EM, Kaneko K, Yatsuoka T, Hayashi Y, Hoshi M, Horii A, Furukawa T
  • Journal Title: DNA Seq 11 Pages: 541-546
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum. (2001)
  • Author(s): Sakurada K, Furukawa T, Kato Y, Kayama T, Huang S, Horii A
  • Journal Title: Genes Chromosomes Cancer 30 Pages: 207-211
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. (2001)
  • Author(s): Sun C, Yamato T, Furukawa T, Ohnishi Y, Kijima H, Horii A
  • Journal Title: Oncol Rep 8 Pages: 89-92
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] requent nuclear accumulation of β-catenin (CTNNB1) in human pituitary adenoma. (2001)
  • Author(s): Semba S, Han S-Y, Ikeda H, Horii A
  • Journal Title: Cancer 91 Pages: 42-48
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Report of the sixth international workshop on human chromosome 1 mapping 2000. (2001)
  • Author(s): Schutte BC, Carpten JD, Forus A, Gregory SG, Horii A, White PS
  • Journal Title: Cytogenet Cell Genet 92 Pages: 23-41
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Allelic loss of the NFI gene in anal malignant melanoma in a patient with neurofibromatosis type 1. (2001)
  • Author(s): Ishii, S., Han, S., Shiiba, K., Mizoi, T., Okabe, M., Horii, A., Nagura, H., Matsuno, S., Sasaki, I.
  • Journal Title: Int.J.Clin.Oncol. 6 Pages: 201-204
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band Ip36. (2001)
  • Author(s): Chen, Y.Z., Soeda, E., Yang, H.W., Takita, J., Chai, L., Horii, A., Inazawa, J., Ohki, M., Hayashi, Y.
  • Journal Title: Genes Chromosomes Cancer 31 Pages: 326-332
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease. (2001)
  • Author(s): Kato, N., Kimura, K., Sugawara, H., Aoyagi, S., Ikeda, T., Horii, A.
  • Journal Title: Int.J.Oncol. 18 Pages: 1017-1022
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino-acid residues within hMLH3, hPMS1, and hPMS2. (2001)
  • Author(s): Kondo, E., Horii, A., Fukushige, S.
  • Journal Title: Nucl.Acids Res. 29 Pages: 1695-1702
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of the human pancreatic secretory trypsin inhibitor (PST1) gene mutations in Japanese patients with chronic pancreatitis. (2001)
  • Author(s): Kaneko, K., Nagasaki, Y., Furukawa, T., Mizutamari, H., Sato, A., Masamune, A., Shimosegawa, T., Horii, A.
  • Journal Title: J.Hum.Genet. 46 Pages: 293-297
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ABAC-basedSTS-contentmapspanninga35-megabase region of human chromosome 1p35-p36. (2001)
  • Author(s): Chen, Y.Z., Hayashi, Y., Wu, J.G., Takaoka, E., Maekawa, K., Watanabe, N., Inazawa, J., Hosoda, F., Arai, Y., Ohki, M., Mizushima, H., Morohoshi, A., Ohira, M., Nakagawara, A., Liu, S.-Y., Hoshi, M., Horii, A., Soeda, E.
  • Journal Title: Genomics 74 Pages: 55-70
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal adenocarcinoma. (2001)
  • Author(s): Inoue, H., Furukawa, T., Sunamura, M., Takeda, K., Matsuno, S., Horii, A.
  • Journal Title: Genes Chromosomes Cancer 31 Pages: 295-299
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Isolation and characterization of the human gene homologous to the Drosophila Headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. (2001)
  • Author(s): Makino, N., Yamato, T, Inoue, H., Furukawa, T., Abe, T., Yokoyama, T., Yatsuoka, T., Fukushige, S., Orikasa, S., Takahashi, T., Horii, A.
  • Journal Title: DNA Seq. 11 Pages: 547-553
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human BAC contig covering the deleted region in pancreatic cancer at 12q21. (2001)
  • Author(s): Youssef, E.M., Kaneko, K, Yatsuoka, T., Hayashi, Y, Hoshi, M., Horii, A., Furukawa, T.
  • Journal Title: DNA Seq. 11 Pages: 541-546
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum. (2001)
  • Author(s): Sakurada, K., Furukawa, T., Kato, Y., Kayama, T., Huang, S., Horii, A.
  • Journal Title: Genes Chromosomes Cancer 30 Pages: 207-211
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. (2001)
  • Author(s): Sun, C., Yamato, T., Furukawa, T., Ohnishi, Y., Kijima, H., Horii, A.
  • Journal Title: Oncol.Rep. 8 Pages: 89-92
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Frequent nuclear accumulation of (3)-catenin (CTNNBI) in human pituitary adenoma. (2001)
  • Author(s): Semba, S., Han, S.-Y., Ikeda, H., Horii, A.
  • Journal Title: Cancer 91 Pages: 42-48
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Report of the sixth international workshop on human chromosome l mapping 2000. (2001)
  • Author(s): Schutte, B.C., Carpten, J.D., Forus, A., Gregory, S.G., Horii, A., White, P.S.
  • Journal Title: Cytogenet.Cell Genet. 92 Pages: 23-41
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1. (2000)
  • Author(s): Saito A, Furukawa T, Fukushige S, Koyama S, Hoshi M, Hayashi Y, Horii A
  • Journal Title: J Hum Genet 45 Pages: 177-181
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma (2000)
  • Author(s): Kadota M, Tamaki Y, Sakita I, Komoike Y, Miyazaki M, Ooka M, Hasuda N, Fujiwara Y, Ohnishi T, Tomita N, Sekimoto M, Ohue M, Ikeda T, Kobayashi T, Horii A, Monden M
  • Journal Title: Oncol Rep 7 Pages: 529-533
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mutational analysis of the CTNNB1 (β-catenin) gene in human endometrial cancer : Frequent mutations at codon 34 that cause nuclear accumulation (2000)
  • Author(s): Ikeda T, Yoshinaga K, Semba S, Kondo E, Ohmori H, Horii A
  • Journal Title: Oncol Rep 7 Pages: 323-326
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss. (2000)
  • Author(s): Hoshi M, Otagiri N, Shiwaku HO, Asakawa S, Shimizu N, Kaneko Y, Ohi R, Hayashi Y, Horii A
  • Journal Title: Br J Cancer 82 Pages: 1801-1807
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer. (2000)
  • Author(s): Ikeda T, Yoshinaga K, Suzuki A, Sakurada A, Ohmori H, Horii A
  • Journal Title: Oncol Rep 7 Pages: 567-570
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells. (2000)
  • Author(s): Shinoura N, Muramatsu Y, Asai A, Han S, Horii A, Kirino T, Hamada H
  • Journal Title: Cancer Lett 160 Pages: 67-73
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular cloning and expression of cDNA encoding chicken UDP-GlcNAc : GlcNAcβ1-6(GlcNAcβ1-2) Manα1-R[GlcNAc to Man]β1, 4N-acetylglucosaminyltransferase VI. (2000)
  • Author(s): Sakamoto Y, Taguchi T, Honke K, Korekane H, Watanabe H, Tano Y, Dohmae N, Takio K, Horii A, Taniguchi N
  • Journal Title: J Biol Chem 275 Pages: 36029-36034
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer. (2000)
  • Author(s): Yuki M, Yoshinaga K, Yamakawa H, Sakurada K, Sato S, Yajima A, Horii A
  • Journal Title: Oncol Rep 7 Pages: 1339-1342
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability. (2000)
  • Author(s): Piao Z, Fang W, Malkhosyan S, Kim H, Horii A, Perucho M, Huang S
  • Journal Title: Cancer Res 60 Pages: 4701-4704
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability (2000)
  • Author(s): Kondo E, Furukawa T, Yoshinaga K, Kijima H, Semba S, Yatsuoka T, Yokoyama T, Fukushige S, Horii A
  • Journal Title: Int J Oncol 17 Pages: 535-541
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line. (2000)
  • Author(s): Ohira M, Kageyama H, Mihara M, Furuta S, Machida T, Shishikura T, Takayasu H, Islam A, Nakamura Y, Takahashi M, Tomioka N, Sakiyama S, Kaneko Y, Toyoda A, Hattori M, Sakaki Y, Ohki M, Horii A, Soeda E, Inazawa J, Seki N, Kuma H, Nozawa I, Nakagawara A
  • Journal Title: Oncogene 19 Pages: 4302-4307
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of the homozygously deleted region at chromosome 1p36.2 in human neuroblastoma. (2000)
  • Author(s): Nakagawara A, Ohira M, Kageyama H, Mihara M, Furuta S, Machida T, Takayasu H, Islam A, Nakamura Y, Takahashi M, Shishikura T, Kaneko Y, Toyoda A, Hattori M, Sakaki Y, Ohki M, Horii A, Soeda E, Inazawa J, Seki N, Kuma H, Nozawa, I, Sakiyama, S
  • Journal Title: Med Pediat Oncol 35 Pages: 516-521
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Deletion mapping of 14q32 in human neuroblastoma defines an 1100-kb region of common allelic loss. (2000)
  • Author(s): Hoshi M, Shiwaku HO, Hayashi Y, Kaneko Y, Horii A
  • Journal Title: Med Pediat Oncol 35 Pages: 522-525
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma. (2000)
  • Author(s): Mayama T, Fukushige S, Shineha R, Nishihira T, Satomi S, Horii A
  • Journal Title: Int J Oncol 17 Pages: 245-252
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium. (2000)
  • Author(s): Semba S, Ouyang H, Han S-Y, Kato Y, Horii A
  • Journal Title: Int J Oncol 16 Pages: 731-737
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. (2000)
  • Author(s): Yatsuoka T, Sunamura M, Furukawa T, Fukushige S, Yokoyama T, Inoue H, Shibuya K, Takeda K, Hatsuno S, Horii A
  • Journal Title: Am J Gastroent 95 Pages: 2080-2085
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells. (2000)
  • Author(s): Shinoura, N., Muramatsu, Y., Asai, A., Han, S., Horii, A., Kirino, T., Hamada, H.
  • Journal Title: Cancer Lett. 160 Pages: 67-73
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular cloning and expression of cDNA encoding chicken UDP-GlcNAc : GlcNAcβ1-6(GlcNAcβ1-2)Mana1-R[GlcNActoMan]pi,4 N-acetylglucosaminyltransferase VI. (2000)
  • Author(s): Sakamoto, Y., Taguchi, T., Honke, K., Korekane, H., Watanabe, H., Tano, Y., Dohmae, N., Takio, K, Horii, A., Taniguchi, N.
  • Journal Title: J.Biol.Chem. 275 Pages: 36029-36034
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer. (2000)
  • Author(s): Yuki, M., Yoshinaga, K., Yamakawa, H., Sakurada, K., Sato, S., Yajima, A., Horii, A.
  • Journal Title: Oncol.Rep. 7 Pages: 1339-1342
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability. (2000)
  • Author(s): Piao, Z., Fang, W., Malkhosyan, S., Kim, H., Horii, A., Perucho, M., Huang, S.
  • Journal Title: Cancer Res. 60 Pages: 4701-4704
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Not hMSH2but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability. (2000)
  • Author(s): Kondo, E., Furukawa, T., Yoshinaga, K., Kijima, H., Semba, S., Yatsuoka, T., Yokoyama, T., Fukushige, S., Horii, A.
  • Journal Title: Int.J.Oncol. 17 Pages: 535-541
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Deletion mapping of 14q32 in human neuroblastoma defines an 1100-kb region of common allelic loss. (2000)
  • Author(s): Hoshi, M., Shiwaku, H.O., Hayashi, Y., Kaneko, Y., Horii, A.
  • Journal Title: Med.Pediat.Onco1. 35 Pages: 522-525
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of the homozygously deleted region at chromosome Ip36.2 in human neuroblastoma. (2000)
  • Author(s): Nakagawara, A., Ohira, M., Kageyama, H., Mihara, M., Furuta, S., Machida, T., Takayasu, H., Islam, A., Nakamura, Y., Takahashi, M., Shishikura, T., Kaneko, Y., Toyoda, A., Hattori, M., Sakaki, Y., Ohki, M., Horii, A., Soeda, E., Inazawa, J., Seki, N., Kuma, H., Nozawa, 1., Sakiyama, S.
  • Journal Title: Med. Pediat. Onco1. 35 Pages: 516-521
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of a 500-kb homozygously deleted region at Ip36.2-p36.3 in a neuroblastoma cell line. (2000)
  • Author(s): Ohira, M., Kageyama, H., Mihara, M., Furuta, S., Machida, T., Shishikura, T., Takayasu, H., Islam, A., Nakamura, Y., Takahashi, M., Tomioka, N., Sakiyama, S., Kaneko, Y., Toyoda, A., Hattori, M., Sakaki, Y., Ohki, M., Horii, A., Soeda, E., Inazawa, J., Seki, N., Kuma, H., Nozawa, I., Nakagawara, A.
  • Journal Title: 0ncogene 19 Pages: 4302-4307
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma. (2000)
  • Author(s): Mayama, T., Fukushige, S., Shineha, R., Nishihira, T., Satomi, S., Horii, A.
  • Journal Title: Int.J.Oncol. 17 Pages: 245-252
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium. (2000)
  • Author(s): Semba, S., Ouyang, H., Han, S.-Y., Kato, Y., Horii, A.
  • Journal Title: Int.J.Oncol. 16 Pages: 731-737
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. (2000)
  • Author(s): Yatsuoka, T., Sunamura, M., Furukawa, T., Fukushige, S., Yokoyama, T., Inoue, H., Shibuya, K., Takeda, K., Matsuno, S., Horii, A.
  • Journal Title: Am.J.Gastroent. 95 Pages: 2080-2085
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer. (2000)
  • Author(s): Ikeda, T., Yoshinaga, K., Suzuki, A., Sakurada, A., Ohmori, H., Horii, A.
  • Journal Title: Oncol.Rep. 7 Pages: 567-570
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] p24/INGI ALTI and p47/ING1 ALTZ, distinct alternative transcripts of p33/INGI. (2000)
  • Author(s): Saito, A., Furukawa, T., Fukushige, S., Koyama, S., Hoshi, M., Hayashi, Y., Horii, A.
  • Journal Title: J.Hum.Genet. 45 Pages: 177-181
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma. (2000)
  • Author(s): Kadota, M., Tamaki, Y., Sakita, 1., Komoike, Y., Miyazaki, M., Ooka, M., Masuda, N., Fujiwara, Y., Ohnishi, T., Tomita, N., Sekimoto, M., Ohue, M., Ikeda, T., Kobayashi, T., Horii, A., Monden, M.
  • Journal Title: Oncol.Rep. 7 Pages: 529-533
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mutational analysis of the CTNNB1 (β-catenin) gene in human endometrial cancer : Frequent mutations at codon 34 that cause nuclear accumulation. (2000)
  • Author(s): Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., Horii, A.
  • Journal Title: Oncol.Rep. 7 Pages: 323-326
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss. (2000)
  • Author(s): Hoshi, M., Otagiri, N., Shiwaku, H.O., Asakawa, S., Shimizu, N., Kaneko, Y., Ohi, R., Hayashi, Y., Horii, A.
  • Journal Title: Br.J.Cancer 82 Pages: 1801-1807
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] The Role of DUSP6/HKP-3 in Pancreatic Carcinoma. In : Hayat MA (ed.) Handbook of immunohistochemistry and in situ hybridization of human carcinomas, volume 3 : Molecular genetics, liver carcinoma, and pancreatic carcinoma (2005)
  • Author(s): Furukawa T, Horii A
  • Publisher: Elsevier (USA), Philadelphia, PA(in press)
  • Description: 「研究成果報告書概要(和文)」より