2004 Fiscal Year Final Research Report Summary
Multi-step carcinogenesis using genetically retired models
| Project/Area Number |
12213139
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Juntendo University School of Medfcine (2003-2004)
Japanese Foundation For Cancer Research (2000-2002) |
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Principal Investigator |
HINO Okio Department of Pathology, Juntendo University School of Medicine, Professor, 医学部, 教授 (90127910)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Toshiyuki Department of Pathology, Juntendo University School of Medicine, Assistant Professor, 講師 (40260070)
HAMANO Yoshitomo Department of Pathology, Juntendo University School of Medicine, Assistant Professor, 講師 (10281354)
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| Project Period (FY) |
2000 – 2004
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| Keywords | Eker rat / Nihon rat / Tsc 1 gene / Tsc 2 gene / Bhd gene / Niban gene / Ere gene / hereditary cancer |
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| Research Abstract |
Cancer is a heritable disorder of somatic cells. Environment and heredity both contribute to the origin of human cancer. The Eker (Tsc 2 gene mutant) rat model of hereditary renal carcinoma (RC) is an example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Carcinogenesis looks like an opened Japanese fan, because initiated cells growing in several directions will develop into tumors having many gene abnormalities, and this is suggested by the edge of the fan. To search for such genetic alterations, we identified genes (Niban and Ere) that were expressed more abundantly in renal tumors than in the normal kidney.
Recently, we discovered a new hereditary renal carcinoma in the rat in Japan, and the rat was named the "Ninon" rat and its predisposing (Bhd) gene could be a novel renal tumor suppressor gene.
We present these unique models for the study of problems in carcinogenesis; eg., multistep carcinogenesis, cancer prevention and the development of the therapeutic treatments which can be translated into human patients, as well as how environmental factors interact with cancer susceptibility gene(s) and discuss the primal force and gene networks (federal headship) in renal carcinogenesis.
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[Journal Article] Identification of the coding sequences responsible for Tsc 2-mediated tumor suppression using a transgenic rat system.2002
Author(s)
Momose, S., Kobayashi, T., Mitani, H., Hirabayashi, M., Ito, K., Ueda, M., Nabeshima, Y., Hino, 0.
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Journal Title
Human Molecular Genetics, 11
Pages: 2997-3006
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Tsc tumor suppressor proteins antagonize amino-acid-TOR signaling.2002
Author(s)
Gao, X., Zhang, Y., Arrazola, P., Hino, 0., Kobayashi, T., Yeung, R.S., Ru, B., Pan, D.
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Journal Title
Nature Cell Biology 4
Pages: 699-704
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A germ-line Tscl mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.2001
Author(s)
Kohayashi, T., Minowa, 0., Sugitani, Y., Takai, S., Mitani, H, Kobayashi, E, Noda, T., Hino, 0.
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Journal Title
Proc.Natl.Acad.Sci.USA 98
Pages: 8762-8767
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Multistep renalcarcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model-genotype, phenotype and environment.2001
Author(s)
Hino, 0., Majima, S., Kobayashi, T., Honda, S., Momose, S., Kikuchi, Y., Mitani, H.
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Journal Title
Mutation Res 477
Pages: 155-164
Description
「研究成果報告書概要(欧文)」より
