2001 Fiscal Year Annual Research Report

ブラジル日系移民を対象としたがんの疫学研究

Research Project

Project/Area Number	12218241
Research Institution	National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Principal Investigator	津金昌一郎国立がんセンター, 研究所・支所・臨床疫学研究部, 部長 (40179982)
Co-Investigator(Kenkyū-buntansha)	花岡知之国立がんセンター, 研究所・支所・臨床疫学研究部, 主任研究官 (00228503) 佐々木敏国立がんセンター, 研究所・支所・臨床疫学研究部, 室長 (70275121)
Keywords	ブラジル日系移民 / がん / 胃がん / 乳がん / 症例対照研究 / 断面研究 / 環境要因 / 遺伝的素因
Research Abstract	ブラジルを中心とする在外で生活する日系人を対象として、がん発生における遺伝的素因と環境要因との関わりについて疫学的手法を用いて検討している。平成13年度は、日系人と非日系人を対象に実施した胃癌の症例対照研究について、Helicobactor pylori(H.p.)のCagA血清抗体を測定し、症例対照間および人種間差について検討した。対照の抗体陽性率に人種間差は認められなかったが、症例対照間差については、非日系人において、胃癌とのより強い関連が認められた。また、DNA酸化的損傷の修復酵素hOGG1のSer326Cys多型解析を行い環境要因との相互作用を検討した結果、症例対照間差よりも人種間差の方が顕著であった。症例数の多い非日系人において、胃癌との関連が示唆された喫煙、野菜摂取頻度、牛肉摂取頻度と、hOGG1多型との相互作用を検討した。その結果、Ser/Ser多型において喫煙がリスク要因となる一方、Cysを含む多型では関連を認めなかった。しかしながら、相互作用に関する統計的有意性は検出されなかった。そして、乳癌の症例対照研究を関連施設の倫理審査承認後に開始し、現時点で、非日系人乳癌症例110例、日系人乳癌症例10例、および、ほぼ同数の対照例の調査を終了した。さらに、サンパウロ州における死因統計作成のため、1999年から2001年の3年間について、日系人データの抽出作業を行い、2000年死亡例について、暫定的解析を行った。日本生まれの1世の死亡票1154例、二世以上の日系人と思われるものの死亡票1468例が収集された。年齢分布が大きく異なるために単純な比較は出来ないが、がん死亡については、一世男性では胃(24%)、二世以降男性では肺(16%)、一世女性では胃(16%)、二世以降女性では乳房(21%)が最も頻度の多い部位であった。

Research Products

(15 results)

All Other

All Publications (15 results)

[Publications] Hanaoka T., et al: "hOGG1 exon7 polymorphism and gastric cancer in case-control studies of Japanese Brazilians and non-Japanese Brazilians"Cancer Lett. 170. 53-61 (2001)
[Publications] Fujioka N., et al: "Serological immunoglobulin G antibody titers to Helicobacter pylori in Japanese Brazilian and Non-Japanese Brazilian gastric cancer patients and controls in Sao Paulo"Jpn J Cancer Res. 92. 829-835 (2001)
[Publications] Koriyama C., et al: "Epstein-barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilians in Sao Paulo"Jpn J Cancer Res. 92. 911-917 (2001)
[Publications] Karita K., et al: "Comparison of selenium status between Japanese living in Tokyo and Japanese Brazilians in Sao Paulo, Brazil"Asia Pacific J Clin Nutr. 10. 197-199 (2001)
[Publications] Zhang J., et al: "Urinary 1-hydroxypyrene in coke oven workers, relative to exposure, alcohol consumption, and metabolic enzymes"Occup Environ Med. 58. 716-721 (2001)
[Publications] Yoshinaga A., et al: "Sensitivity of self-reports of cancer in a population-based prospective study : JPHC Study Cohort I"J Clin Epidemiol. 54. 741-746 (2001)
[Publications] Tsubono Y., et al: "Food composition and empirical weight methods in predicting nutrient intakes from food frequency questionnaire"Ann Epidemiol. 11. 213-218 (2001)
[Publications] Kobayashi M., et al: "Single measurement of serum phospholipid fatty acid as a biomarker of specific fatty acid intake in middle-aged Japanese men"Eur J Clin Nutr. 55. 643-650 (2001)
[Publications] Takahashi Y., et al: "Development and validation of specific carotene food composition tables for use in nutritional epidemiologic studies for Japanese populations"J Epidemiol. 11. 266-275 (2001)
[Publications] Tatemichi M., et al: "Effect of smoking on serum pepsinogen I level depends on serological status of Helicobacter pylori"Jpn J Cancer Res. 92. 243-248 (2001)
[Publications] Sasaki S., et al: "Association between current nutrient intakes and bone mineral density at calcaneus in pre-and postmenopausal Japanese women"J Nutr Sci Vitaminol. 47. 289-294 (2001)
[Publications] Hara M., et al: "Smoking and risk of premature death among middle-aged Japanese : ten-year follow-up of the Japan public center-based prospective study on cancer and cardiovascular disease(JPHC Study)Cohort I"Jpn J Cancer Res. 93. 6-14 (2002)
[Publications] Tsugane S., et al: "Under and Over-weight Impact on Mortality among Middle-aged Japanese Men and Women : a Ten-year Follow-up of JPHC Study Cohort I"Int J Obesity. (in press).
[Publications] Sobue T., et al: "Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women : the JPHC Study"Int J Cancer. (in press).
[Publications] Hanaoka T., et al: "Residuals of beta-hexachlorocyclohexane, dichlorodiphenyltrichloroethane, and hexachlorobenzene in serum, and relations with consumption of dietary components in rural residents in Japan"Science Total Environ. (in press).

2001 Fiscal Year Annual Research Report

ブラジル日系移民を対象としたがんの疫学研究

Principal Investigator

津金 昌一郎 国立がんセンター, 研究所・支所・臨床疫学研究部, 部長 (40179982)

Research Products

[Publications] Hanaoka T., et al: "hOGG1 exon7 polymorphism and gastric cancer in case-control studies of Japanese Brazilians and non-Japanese Brazilians"Cancer Lett. 170. 53-61 (2001)

[Publications] Fujioka N., et al: "Serological immunoglobulin G antibody titers to Helicobacter pylori in Japanese Brazilian and Non-Japanese Brazilian gastric cancer patients and controls in Sao Paulo"Jpn J Cancer Res. 92. 829-835 (2001)

[Publications] Koriyama C., et al: "Epstein-barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilians in Sao Paulo"Jpn J Cancer Res. 92. 911-917 (2001)

[Publications] Karita K., et al: "Comparison of selenium status between Japanese living in Tokyo and Japanese Brazilians in Sao Paulo, Brazil"Asia Pacific J Clin Nutr. 10. 197-199 (2001)

[Publications] Zhang J., et al: "Urinary 1-hydroxypyrene in coke oven workers, relative to exposure, alcohol consumption, and metabolic enzymes"Occup Environ Med. 58. 716-721 (2001)

[Publications] Yoshinaga A., et al: "Sensitivity of self-reports of cancer in a population-based prospective study : JPHC Study Cohort I"J Clin Epidemiol. 54. 741-746 (2001)

[Publications] Tsubono Y., et al: "Food composition and empirical weight methods in predicting nutrient intakes from food frequency questionnaire"Ann Epidemiol. 11. 213-218 (2001)

[Publications] Kobayashi M., et al: "Single measurement of serum phospholipid fatty acid as a biomarker of specific fatty acid intake in middle-aged Japanese men"Eur J Clin Nutr. 55. 643-650 (2001)

[Publications] Takahashi Y., et al: "Development and validation of specific carotene food composition tables for use in nutritional epidemiologic studies for Japanese populations"J Epidemiol. 11. 266-275 (2001)

[Publications] Tatemichi M., et al: "Effect of smoking on serum pepsinogen I level depends on serological status of Helicobacter pylori"Jpn J Cancer Res. 92. 243-248 (2001)

[Publications] Sasaki S., et al: "Association between current nutrient intakes and bone mineral density at calcaneus in pre-and postmenopausal Japanese women"J Nutr Sci Vitaminol. 47. 289-294 (2001)

[Publications] Hara M., et al: "Smoking and risk of premature death among middle-aged Japanese : ten-year follow-up of the Japan public center-based prospective study on cancer and cardiovascular disease(JPHC Study)Cohort I"Jpn J Cancer Res. 93. 6-14 (2002)

[Publications] Tsugane S., et al: "Under and Over-weight Impact on Mortality among Middle-aged Japanese Men and Women : a Ten-year Follow-up of JPHC Study Cohort I"Int J Obesity. (in press).

[Publications] Sobue T., et al: "Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women : the JPHC Study"Int J Cancer. (in press).

[Publications] Hanaoka T., et al: "Residuals of beta-hexachlorocyclohexane, dichlorodiphenyltrichloroethane, and hexachlorobenzene in serum, and relations with consumption of dietary components in rural residents in Japan"Science Total Environ. (in press).

津金昌一郎国立がんセンター, 研究所・支所・臨床疫学研究部, 部長 (40179982)