| Project/Area Number |
12307013
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MIZUSAWA Hidehiro TOKYO MEDICAL AND DENTAL UNIVERSITY, DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, PROFESSOR, 大学院・医歯学総合研究科, 教授 (30144091)
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| Co-Investigator(Kenkyū-buntansha) |
KANOUCHI Tadashi TOKYO MEDICAL AND DENTAL UNIVERSITY, DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, ASSISTANT LECTURER, 医学部附属病院, 助手 (50345287)
ISHIKAWA Kinya TOKYO MEDICAL AND DENTAL UNIVERSITY, DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, ASSISTANT LECTURER, 医学部附属病院, 助手 (30313240)
YOKOTA Takanori TOKYO MEDICAL AND DENTAL UNIVERSITY, DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, ASSISTANT PROFESSOR, 医学部附属病院, 講師 (90231688)
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| Project Period (FY) |
2000 – 2002
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| Keywords | SPINOCEREBELLAR DEGENERATION / CAG REPEAT / SCA6 / CA CHANNEL / PURKINJE CELL / ANIMAL MODEL / CACNA1A / αTTP |
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| Research Abstract |
In the research on pathogenesis of spinocerebellar ataxia type 6 (SCA6), we found Purkinje cell specific inclusions and SCA6 gene resulted in Ca channel abnormality in cultured cells. A new gene locus for pure cerebellar ataxia was disclosed and the candidate area was narrowed. Regarding glial cytoplasmic inclusions in multiple system atrophy, we identified the 7 KD core fragment of α-synuclein molecule.
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